3-Isopropylmalate Dehydrogenase (3 Isopropylmalate Dehydrogenase)

An NAD+ dependent enzyme that catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate to 3-carboxy-4-methyl-2-oxopentanoate. It is involved in the biosynthesis of VALINE; LEUCINE; and ISOLEUCINE.

Also Known As:

3 Isopropylmalate Dehydrogenase; beta-IPM Dehydrogenase; beta-Isopropylmalate Dehydrogenase; Dehydrogenase, 3-Isopropylmalate; Dehydrogenase, beta-IPM; Dehydrogenase, beta-Isopropylmalate; beta IPM Dehydrogenase; beta Isopropylmalate Dehydrogenase

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Alcohol Oxidoreductases: 56
      - NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases
        3-Isopropylmalate Dehydrogenase: 1
        S cerevisiae LEU2 protein

Related Diseases

1.	Starvation 01/25/1983 - "The level of beta-IPM dehydrogenase, the leuB enzyme, was elevated 40-fold in a strain carrying one of these mutations, and starvation of this strain for leucine had little effect on the amount of activity expressed. "

Related Drugs and Biologics

1.	Leucine (L-Leucine)
2.	Enzymes