Chronic Pancreatitis

INFLAMMATION of the PANCREAS that is characterized by recurring or persistent ABDOMINAL PAIN with or without STEATORRHEA or DIABETES MELLITUS. It is characterized by the irregular destruction of the pancreatic parenchyma which may be focal, segmental, or diffuse.

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Networked: 4025 relevant articles (173 outcomes, 426 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Pancreatitis
3.	Pancreatic Neoplasms (Pancreatic Cancer)
4.	Fibrosis (Cirrhosis)
5.	Pathologic Constriction (Stenosis)

Experts

1.	Friess, Helmut: 47 articles (08/2014 - 02/2002)
2.	Büchler, Markus W: 38 articles (01/2015 - 01/2002)
3.	Whitcomb, David C: 31 articles (01/2015 - 01/2002)
4.	Friess, H: 29 articles (01/2012 - 01/2000)
5.	Sahin-Tóth, Miklós: 26 articles (10/2015 - 11/2003)
6.	Büchler, M W: 25 articles (01/2012 - 02/2000)
7.	Witt, Heiko: 23 articles (01/2016 - 05/2002)
8.	Lerch, Markus M: 23 articles (09/2015 - 11/2003)
9.	Kleeff, Jörg: 23 articles (05/2013 - 09/2002)
10.	Conwell, Darwin L: 21 articles (10/2013 - 06/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chronic Pancreatitis:

1.	SecretinFDA Link 01/01/2004 - "The gold standard used for the diagnosis of chronic pancreatitis was the final result of the complete 60-minute secretin stimulation test. " 04/01/2000 - "Even in chronic pancreatitis a significant improvement of imaging quality could be observed, but only in patients without duct dilation before secretin. " 12/01/2008 - "The purpose of this study was to determine the improvement in sensitivity and specificity of magnetic resonance cholangiopancreaticography (MRCP) in the diagnosis of chronic pancreatitis due to the application of secretin. " 01/01/1985 - "Modern diagnostic tests such as sonography, CT, ERCP and the secretin-CCK test do not provide a "gold standard" for early chronic pancreatitis. " 10/01/2009 - "The aim of this study was to compare radial and linear EUS for the diagnosis of chronic pancreatitis using the secretin-stimulated endoscopic pancreatic function test (ePFT) as the reference standard. "
2.	Glucose (Dextrose)FDA LinkGeneric 05/01/1996 - "False-negative findings were mainly due to disturbance of glucose metabolism in diabetic patients, while most false-positive results could be attributed to acute inflammatory lesions in chronic pancreatitis. " 01/01/1989 - "During the follow-up period in 81% of the patients the glucose metabolism was unchanged, in 13% it deteriorated, and in 5% it improved permanently; 80% of the patients had a marked increase in weight averaging 8.7 kg. Compared to the Whipple procedure the duodenum-preserving resection of the head of the pancreas spares the patient with chronic pancreatitis a gastric resection, the duodenectomy, and the resection of the extrahepatic bile ducts. " 01/01/2008 - "Changes in glucose metabolism after PD depend on the etiology of pancreatic tumorous lesion with improvement in neoplasmatic patients and deterioration in chronic pancreatitis patients." 04/01/1970 - "[Study of insulinemia after oral glucose load in chronic pancreatitis]." 06/01/2010 - "Determinants of glucose control in patients with chronic pancreatitis."
3.	EnzymesIBA 01/01/2009 - "To evaluate the efficacy of pancreatic enzymes in patients with chronic pancreatitis. " 08/01/2015 - "This study was aimed to determine the relationship of alcohol-metabolizing enzymes ADH2, ADH3, and ALDH2 polymorphisms with the susceptibility to alcoholic chronic pancreatitis (ACP). " 11/01/2012 - "Rational use of pancreatic enzymes in patients with chronic pancreatitis." 01/01/2012 - "Responding patients were included if they had chronic pancreatitis and were treated for exocrine insufficiency with pancreatic enzymes. " 07/01/2009 - "The authors report that chronic pancreatitis changes will be seen in up to a third of patients with asymptomatic elevations in pancreas enzymes when compared with age-matched controls. "
4.	TrypsinIBA 01/01/1985 - "In chronic pancreatitis, in a stage of remission, the level of serum immunoreactive trypsin is significantly lower as compared with the control group (p less than 0,01). " 03/01/2012 - "Pancreatic secretory trypsin inhibitor I reduces the severity of chronic pancreatitis in mice overexpressing interleukin-1β in the pancreas." 07/01/2007 - "The diagnostic power of endoscopy may be enhanced by the collection of a pancreatic juice sample after enteral feed stimulation because measurement of the trypsin content will identify chronic pancreatitis patients who will be benefited by enzyme supplementation." 01/01/1985 - "The serum immunoreactive trypsin (determined by RIA-gnost Trypsin of the firm Höchst) was studied in 30 patients with chronic pancreatitis: 16 patients in a stage of exacerbation and 14 patients with clinical remission. " 01/01/2005 - "In this study, we tested the hypothesis that the E32del genetic variant of mesotrypsin might represent a risk factor for the development of chronic pancreatitis, as a result of enhanced degradation of pancreatic secretory trypsin inhibitor. "
5.	AmylasesFDA Link 04/01/2014 - "Previous studies have shown that lower serum amylase levels are associated with chronic pancreatitis. " 01/01/2011 - "Some early studies have revealed that serum amylase levels are lower in individuals with chronic pancreatitis, severe long-term type 2 diabetes or type 1 diabetes. " 01/01/2008 - "The aim of this study is to prove the influence of tobacco smoking on total and thermolability amylase activity in the serum of non-smoking and smoking health persons and patients with diagnosed acute (AP), chronic exaggerated (CEP) and chronic pancreatitis (CP) and patients with diabetes. " 08/01/1985 - "Results for total amylase are not reliable so that its use in the study of chronic pancreatitis is not advisable." 03/01/2014 - "Asymptomatic patients with chronic pancreatitis not infrequently have elevated concentrations of amylase, even though detailed examination reveals no indication of an acute exacerbation. "
6.	AntioxidantsIBA 04/01/2012 - "Antioxidants and chronic pancreatitis: theory of oxidative stress and trials of antioxidant therapy." 07/01/2009 - "Postrandomization dropouts and other issues threaten validity of trial results of antioxidants in chronic pancreatitis." 01/01/2005 - "So far, there are no studies which reporting potential role of OFRs in development of chronic pancreatitis with the prevention with antioxidants. " 01/01/2014 - "One medical option is to use antioxidants for both preventing and curing the flare-ups of chronic pancreatitis. " 11/01/2013 - "Chronic pancreatitis: role of oxidative stress and antioxidants."
7.	Pancreatic Elastase (Elastase)IBA 01/01/1987 - "Most patients with chronic pancreatitis studied during clinical remission (39 out of 43) had serum elastase levels either within (n = 24) or below (n = 15) the control range. " 07/01/2009 - "In this study, we prospectively compared the use of endoscopic retrograde cholangiopancreatography (ERCP), endoscopic ultrasonography (EUS), and fecal elastase 1 in patients with chronic pancreatitis and searched for correlation with symptoms, clinical findings, and elastase 1 levels. " 10/01/2008 - "To study the potential effect of p53 mutation in chronic pancreatitis, elastase sshIL-1beta mice were crossed with p53(R172H) mice. " 01/01/2006 - "The aim of our study was Faecal Elastase I. determination in patients with chronic pancreatitis. " 10/01/2014 - "Low level of fecal elastase 1 was associated with marked rather than mild chronic pancreatitis; however, it may be useful to indicate pancreatic exocrine insufficiency in asymptomatic former alcohol addicts."
8.	Pancrelipase (Creon)FDA Link 10/01/1996 - "With the purpose of enhancing efficacy of health-resort treatment of chronic pancreatitis, patients with relevant clinical form and stage of the disease course, early revealed distinguishing features of disturbances in the exocrine function of pancrease should be referred to those health resorts having adequate mineral waters. " 06/01/2009 - "Delayed release pancrelipase for treatment of pancreatic exocrine insufficiency associated with chronic pancreatitis." 05/01/2011 - "Creon has also demonstrated safety and efficacy in EPI secondary to chronic pancreatitis and pancreatectomy. " 08/01/1989 - "The effect of self-administration (ad lib) of pancreatic enzyme substitution (Pancrease) in comparison with the dosage recommended by the manufacturer on abdominal symptoms and nutritional variables was studied in 10 patients with chronic pancreatitis. " 10/01/2010 - "Pancrelipase delayed-release capsules (CREON) for exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery: A double-blind randomized trial."
9.	Insulin (Novolin)FDA Link 01/01/1983 - "Efficacy of continuous subcutaneous insulin infusion in unstable diabetes secondary to chronic pancreatitis: a case report." 03/01/2012 - "The aim of this study was to evaluate the effectivity and safety of insulin therapy in patients with DM secondary to underlying chronic pancreatitis with initially inappropriate glycemic control. " 07/01/2010 - "The aim of the study was to estimate insulin sensitivity in chronic pancreatitis in view of the coexisting meta bolic syndrome components. " 06/01/1988 - "The aim of the present study was to evaluate insulin secretion by the pancreatic B cell in a group of patients with severe chronic pancreatitis and without overt diabetes. " 07/01/2015 - "In the 3914 subjects without diabetes, the only statistically significant comorbidity contributing to pancreatogenic diabetes was chronic pancreatitis (odds ratio, 1.446; 95% CI, 1.146-1.823; P = 0.002).Subjects with comorbid chronic pancreatitis and use of insulin had lower rates of resolution of DM after PD. "
10.	Lipase (Acid Lipase)FDA Link 01/01/1992 - "In the 35 patients with chronic pancreatitis studied during clinical remission, serum lipase levels were abnormally high in 8 (23%), and abnormally low in 3 (9%). " 01/01/2013 - "The variable number of tandem repeats (VNTR) in the last exon of the carboxyl-ester lipase (CEL) gene has been reported to associate with alcohol-induced chronic pancreatitis (ACP) in a Japanese study. " 01/01/2005 - "The aim of this study is to prove the influence of tobacco smoking on lipase activity in the blood of smoking and non-smoking health persons and in smoking and non-smoking patients with diagnosed acute (AP), chronic exaggerated (CEP) and chronic pancreatitis (CP). " 01/01/2016 - "Genetic variants of lipase activity in chronic pancreatitis." 10/13/2015 - "Lipase gene fusion: a new route to chronic pancreatitis."

Therapies and Procedures

1.	Pancreatectomy 01/01/2015 - "Total pancreatectomy with islet cell autotransplantation is being proposed as a treatment for chronic pancreatitis and recent studies report a more favorable outcome in children compared to adults. " 10/01/2013 - "This study aims to review surgical outcomes of pediatric patients undergoing total pancreatectomy with islet cell autotransplantation (TP/IAT) for the treatment of chronic pancreatitis (CP). " 07/01/2013 - "Previous studies have shown that total pancreatectomy with islet cell autotransplantation improves quality of life in chronic pancreatitis. " 11/01/2005 - "The present study describes the first islet autotransplant program in Romania, and the first 3 cases of subtotal pancreatectomy for chronic pancreatitis combined with islet autotransplant. " 01/01/2004 - "Since our first trial and success of spleen-preserving distal pancreatectomy with conservation of the splenic artery and vein for chronic pancreatitis, this procedure has been more frequently performed and reported. "
2.	Stents 03/01/2005 - "Although it has been proved that pancreatic stenting is effective in the symptomatic management of severe chronic pancreatitis, long-term outcomes after stent removal have not been fully evaluated. " 10/01/2004 - "The objective of this study was to determine the efficacy of pancreatic duct stent placement for the treatment of chronic pancreatitis. " 06/01/2000 - "The aim of this study was to evaluate the efficacy of endoscopic stent placement in patients with PD presenting with chronic pancreatitis. " 07/01/2010 - "CHE-EUS increased the detection of malignant lesions in difficult cases (patients with chronic pancreatitis or biliary stents) and helped guide EUS-FNA. " 04/01/2015 - "We performed endoscopic retrograde cholangiopancreatography (ERCP) with sphincterotomy for pancreatic stent placement on a 55-year-old woman with a dilated pancreatic duct, pancreatic duct stone, and chronic pancreatitis. "
3.	Pancreaticoduodenectomy 01/01/2002 - "During the past three decades, important advances in our understanding of the pathophysiology of chronic pancreatitis (CP), improved results of major pancreatic resections (including pancreatoduodenectomy), and integration of sophisticated diagnostic methods in clinical practice resulted in significant changes in our surgical approach to CP. " 11/01/2003 - "Pancreatic function did not deteriorate after pancreatoduodenectomy for chronic pancreatitis with an inflammatory mass of pancreatic head, while quality of life was significantly improved." 12/01/2007 - "The purpose of this study is to examine the efficacy of feeding tubes placed during pancreaticoduodenectomy in patients with chronic pancreatitis. " 11/01/2013 - "The aim of this study was to report on 15-year long-term results of a randomized controlled trial comparing extended drainage procedure (Frey) and classical resectional procedure [pylorus-preserving pancreatoduodenectomy (PD)] in patients with chronic pancreatitis. " 10/01/2012 - "All controlled experimental (randomized and nonrandomized) studies in which duodenum-preserving pancreatic head resection was compared with pancreaticoduodenectomy in chronic pancreatitis. "
4.	Pancreaticojejunostomy 01/01/1981 - "In our series, long pancreaticojejunostomy appears to be the most effective treatment of chronic pancreatitis in the alcoholic, with 87% good to fair results, and with 90% good results in the non-alcoholic. " 06/01/2014 - "Full-length lateral pancreaticojejunostomy is safe, feasible, and effective for managing chronic pancreatitis. " 05/01/2006 - "Longitudinal pancreaticojejunostomy is safe and cost-effective for treating pediatric chronic pancreatitis. " 03/01/1997 - "The present study was designed to determine the efficacy of pancreatic enzyme supplementation in maintaining postoperative digestion and nutrition in patients who had received the local resection-longitudinal pancreaticojejunostomy (LR-LPJ) procedure for chronic pancreatitis. " 06/01/2014 - "The study aim was to determine the short- and long-term results of lateral pancreaticojejunostomy for chronic pancreatitis at a single center in Japan. "
5.	Lithotripsy (Extracorporeal Shockwave Lithotripsy) 08/01/2012 - "For treating painful uncomplicated chronic pancreatitis, the ESGE recommends extracorporeal shockwave lithotripsy/endoscopic retrograde cholangiopancreatography as the first-line interventional option. " 10/01/2002 - "Records were retrospectively analyzed for 125 patients with symptoms caused by chronic pancreatitis with pancreatic duct stones (single 43, multiple 82) treated by interventional endoscopy, including extracorporeal shockwave lithotripsy. " 09/01/2000 - "Extracorporeal shockwave lithotripsy combined with endoscopic therapy failed to benefit patients with calcific chronic pancreatitis." 09/01/1999 - "There have been conflicting reports as to whether pancreatic ductal drainage achieved by endoscopy and lithotripsy improves the clinical outcome of patients with chronic pancreatitis. " 03/01/1996 - "Over a 2 year period, 10 patients with pancreatic stones due to alcohol induced chronic pancreatitis (proven by endoscopic retrograde pancreatography) underwent extracorporeal shockwave lithotripsy. "