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Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)

Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of serotonergic neurons. They are different than SEROTONIN RECEPTORS, which signal cellular responses to SEROTONIN. They remove SEROTONIN from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. Regulates signal amplitude and duration at serotonergic synapses and is the site of action of the SELECTIVE SEROTONIN REUPTAKE INHIBITORS.
Also Known As:
Serotonin Transporter; 5-Hydroxytryptamine Plasma Membrane Transport Protein; 5HT Transporter; Platelet Serotonin Transporter; SERT Proteins; SLC6A4 Protein; Serotonectin; Serotonin Transporter, Platelets; Sodium-Dependent Serotonin Transporter; Solute Carrier Family 6, Member 4 Protein; 5 Hydroxytryptamine Plasma Membrane Transport Protein; Neurotransmitter Transport Proteins, Serotonin Specific; Neurotransmitter Transporters, Serotonin Specific; Platelets Serotonin Transporter; Serotonin Transporter, Platelet; Serotonin Transporter, Sodium-Dependent; Serotonin-Specific Neurotransmitter Transporters; Sodium Dependent Serotonin Transporter; Transporter, Sodium-Dependent Serotonin; Neurotransmitter Transport Proteins, Serotonin-Specific; Neurotransmitter Transporters, Serotonin-Specific; Serotonin Plasma Membrane Transporter Proteins
Networked: 1776 relevant articles (30 outcomes, 377 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Serretti, Alessandro: 21 articles (01/2020 - 05/2002)
2. Golimbet, V E: 17 articles (01/2016 - 12/2000)
3. Lesch, Klaus-Peter: 16 articles (10/2019 - 01/2003)
4. Goldman, David: 14 articles (06/2014 - 01/2002)
5. Mann, J John: 12 articles (08/2022 - 11/2004)
6. Homberg, Judith R: 12 articles (10/2021 - 01/2010)
7. Murphy, Dennis L: 12 articles (08/2013 - 01/2003)
8. Booij, Jan: 11 articles (10/2021 - 05/2004)
9. Lorenzi, Cristina: 11 articles (01/2020 - 05/2002)
10. Parsey, Ramin V: 11 articles (01/2020 - 11/2004)

Related Diseases

1. Major Depressive Disorder (Major Depressive Disorders)
2. Mood Disorders (Mood Disorder)
3. Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder)
4. Autistic Disorder (Autism)
5. Anxiety Disorders (Anxiety Disorder)

Related Drugs and Biologics

1. Serotonin (5 Hydroxytryptamine)
2. Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)
3. Antidepressive Agents (Antidepressants)
4. Proteins (Proteins, Gene)
5. 3- amino- 4- (2- dimethylaminomethylphenylsulfanyl)benzonitrile
6. Fluoxetine (Prozac)
7. Lithium
8. Norepinephrine Plasma Membrane Transport Proteins (Norepinephrine Transporter)
9. Serotonin Receptors
10. Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)

Related Therapies and Procedures

1. Drug Tapering
2. Tissue Transplantation
3. Ligation
4. Therapeutics
5. Drug Therapy (Chemotherapy)