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Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)

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Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of serotonergic neurons. They are different than SEROTONIN RECEPTORS, which signal cellular responses to SEROTONIN. They remove SEROTONIN from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. Regulates signal amplitude and duration at serotonergic synapses and is the site of action of the SEROTONIN UPTAKE INHIBITORS.

Also Known As:

Serotonin Transporter; Transporter, Serotonin; 5-Hydroxytryptamine Plasma Membrane Transport Protein; 5HT Transporter; Platelet Serotonin Transporter; SERT Proteins; Serotonectin; Serotonin Transporter, Platelets; Sodium-Dependent Serotonin Transporter; 5 Hydroxytryptamine Plasma Membrane Transport Protein; Neurotransmitter Transport Proteins, Serotonin Specific; Neurotransmitter Transporters, Serotonin Specific; Platelets Serotonin Transporter; Serotonin Transporter, Platelet; Serotonin Transporter, Sodium-Dependent; Serotonin-Specific Neurotransmitter Transporters; Sodium Dependent Serotonin Transporter; Transporter, Platelet Serotonin; Transporter, Platelets Serotonin; Transporter, Sodium-Dependent Serotonin; Transporters, Serotonin-Specific Neurotransmitter; Neurotransmitter Transport Proteins, Serotonin-Specific; Neurotransmitter Transporters, Serotonin-Specific; Serotonin Plasma Membrane Transporter Proteins

Networked: 1187 relevant articles (21 outcomes, 253 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Carrier Proteins: 11456
    - Membrane Transport Proteins: 165
      - Ion Pumps: 30
        Symporters: 41
        Serotonin Plasma Membrane Transport Proteins: 1187
        C elegans mod-5 protein
        Drosophila SerT protein
        human SLC6A4 protein
        mouse Slc6a4 protein
        rat Slc6a4 protein
      - Neurotransmitter Transport Proteins: 16
        Plasma Membrane Neurotransmitter Transport Proteins
        Serotonin Plasma Membrane Transport Proteins: 1187
        C elegans mod-5 protein
        Drosophila SerT protein
        human SLC6A4 protein
        mouse Slc6a4 protein
        rat Slc6a4 protein
  - Membrane Proteins: 5300
    - Membrane Transport Proteins: 165
      - Ion Pumps: 30
        Symporters: 41
        Serotonin Plasma Membrane Transport Proteins: 1187
        C elegans mod-5 protein
        Drosophila SerT protein
        human SLC6A4 protein
        mouse Slc6a4 protein
        rat Slc6a4 protein
      - Neurotransmitter Transport Proteins: 16
        Plasma Membrane Neurotransmitter Transport Proteins
        Serotonin Plasma Membrane Transport Proteins: 1187
        C elegans mod-5 protein
        Drosophila SerT protein
        human SLC6A4 protein
        mouse Slc6a4 protein
        rat Slc6a4 protein

Experts

1.	Serretti, Alessandro: 17 articles (02/2016 - 05/2002)
2.	Golimbet, V E: 15 articles (01/2014 - 12/2000)
3.	Goldman, David: 14 articles (06/2014 - 01/2002)
4.	Lesch, Klaus-Peter: 12 articles (01/2013 - 01/2003)
5.	Cook, Edwin H: 10 articles (08/2015 - 03/2002)
6.	Adnot, Serge: 10 articles (02/2015 - 03/2002)
7.	Murphy, Dennis L: 10 articles (08/2013 - 01/2003)
8.	Gelernter, Joel: 10 articles (05/2013 - 09/2002)
9.	Kaleda, V G: 10 articles (03/2008 - 12/2000)
10.	Mann, J John: 9 articles (01/2016 - 11/2004)

Related Diseases

1.	Major Depressive Disorder (Major Depressive Disorders) 03/01/2012 - "Serotonin transporter clustering in blood lymphocytes as a putative biomarker of therapeutic efficacy in major depressive disorder." 10/01/2008 - "Serotonin transporter binding as a possible predictor of one-year remission in major depressive disorder." 08/01/2015 - "Although results from individual studies diverge, meta-analysis indicates a trend towards reduced serotonin transporter availability in patients with major depressive disorder. " 08/01/2015 - "We review studies that use PET to measure cerebral serotonin transporter activity in psychiatric disorders, focusing on major depressive disorder and antidepressant treatment. " 06/01/2015 - "Animal and cell line studies demonstrated that miR-16 may be associated with major depressive disorder (MDD) via regulation of the expression of serotonin transporter (SERT) gene. "
2.	Autistic Disorder (Autism) 01/01/2002 - "The serotonin transporter gene (SLC6A4, MIM 182138) is a candidate gene in autistic disorder based on neurochemical, neuroendocrine studies and the efficacy of potent serotonin transporter inhibitors in reducing ritualistic behaviors and related aggression. " 05/01/1997 - "The serotonin transporter gene (HTT) is a primary candidate in autistic disorder based on efficacy of potent serotonin transporter inhibitors in reducing rituals and routines. " 08/01/2015 - "Pharmacogenetic Study of Serotonin Transporter and 5HT2A Genotypes in Autism." 09/01/2011 - "This study was aimed at assessing facial emotion recognition in parents of children with autism and its associations with a functional polymorphism of the serotonin transporter (5HTTLPR). " 05/01/2006 - "The results of previous reports about family-based association studies between the serotonin transporter (5-HTT) gene promoter polymorphism and autism are controversial. "
3.	Anxiety Disorders (Anxiety Disorder) 08/01/2014 - "Anxiety disorders and anxiety-related traits and serotonin transporter gene-linked polymorphic region (5-HTTLPR) in adolescents: case-control and trio studies." 03/01/2010 - "The current study aimed to determine the relationship between ecstasy use and depressive/anxiety symptomatology after controlling for known environmental and genetic (polymorphism of the serotonin transporter gene) risk factors for depression and anxiety disorders. " 06/01/2009 - "Therefore, in the present study 62 patients with social anxiety disorder and 62 age- and sex-matched healthy controls were investigated for the influence of serotonin transporter (5-HTT) gene variation (5-HTTLPR, rs25531) on blushing propensity as measured by the blushing propensity scale (BPS). " 01/01/2006 - "Several studies have focused on the role of the 5HTTLPR polymorphism of the serotonin transporter gene in the background of affective and anxiety disorders. " 08/01/2015 - "The s-allele of the serotonin transporter-linked polymorphic region (5-HTTLPR) has been implicated in the pathophysiology of both BD and anxiety disorders and has been associated with pharmacological treatment response and increased risk for antidepressant side effects. "
4.	Mood Disorders (Mood Disorder) 03/01/2013 - "This article aims to review the studies exploring the moderating role of serotonin transporter on the effect of environmental adversities over time, particularly during childhood and adolescence, which is when level of internalizing symptoms and prevalence of mood disorders change substantially. " 09/05/2007 - "Several studies have implicated an insertion/deletion polymorphism in the promoter region of the serotonin transporter gene (SLC6A4; 5-HTT) in the development of mood disorders. " 03/01/2007 - "The serotonin transporter gene promoter polymorphism (5-HTTLPR) has been repeatedly associated with antidepressant response in mood disorder patients, but findings are not consistent across studies. " 11/01/2004 - "As yet, there is no widely-accepted genetic association finding in mood disorders, but functional candidate genes, such as the serotonin transporter, and positional candidates, such as G72/G30 on chromosome 13q, are beginning to be identified in several studies. " 08/01/2004 - "Pharmacogenetic studies in mood disorders are raising increasing interest, after the first findings of a significant association between antidepressant response and a functional polymorphism in the upstream regulatory region of the serotonin transporter gene (SERTPR). "
5.	Schizophrenia (Dementia Praecox) 12/03/2015 - "Our previous study suggested that the coiled coil domain-containing 55 gene (CCDC55), also named as NSRP1 (nuclear speckle splicing regulatory protein 1 (NSRP1)), was encompassed in a haplotype block spanning over the serotonin transporter (5-HTT) gene in patients with schizophrenia (SCZ). " 01/30/2015 - "Serotonin transporter availability in thalamic subregions in schizophrenia: a study using 7.0-T MRI with [(11)C]DASB high-resolution PET." 03/01/2010 - "[Lack of association between the insertion/deletion polymorphism in serotonin transporter gene, T102C polymorphism of the 5HT2A receptor gene and schizophrenia--family based study]." 09/01/2009 - "In this study, we examined the genetic roles of five polymorphisms of SLC6A4, including those of the widely studied 44 base pair variable number of tandem repeat (VNTR) in the promoter region of SLC6A4 (the serotonin transporter gene-linked polymorphic region: 5HTTLPR) and a VNTR polymorphism (STin2) in the second intron, in schizophrenia and its influence on the severity of symptoms in a South Indian population from Kerala, comprising 586 individuals. " 03/17/2009 - "Further studies with a larger number of subjects are required to better understand the role of the serotonin transporter polymorphism in schizophrenia."

Related Drugs and Biologics

1.	Serotonin Uptake Inhibitors (Serotonin Reuptake Inhibitors)
2.	Serotonin (5 Hydroxytryptamine)
3.	Lithium
4.	Fluoxetine (Prozac)
5.	Citalopram (Escitalopram)
6.	5-HT2A Serotonin Receptor (5 HT2A Receptor)
7.	3- amino- 4- (2- dimethylaminomethylphenylsulfanyl)benzonitrile
8.	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)
9.	Antidepressive Agents (Antidepressants)
10.	Norepinephrine Plasma Membrane Transport Proteins (Norepinephrine Transporter)

Related Therapies and Procedures

1.	Tissue Transplantation
2.	Drug Therapy (Chemotherapy)
3.	Psychophysiology (Physiological Psychology)
4.	Phototherapy (Light Therapy)
5.	Laparotomy