Neurotransmitter Transport Proteins (Neurotransmitter Transporters)

Membrane transport proteins found predominately in NEURONS and neuroendocrine cells that facilitate neurotransmitter transport. They include two distinct families of proteins that transport NEUROTRANSMITTERS across the PLASMA MEMBRANE and that transport NEUROTRANSMITTERS into SECRETORY VESICLES.

Also Known As:

Networked: 24 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Joseph, Deepthi: 1 article (01/2021)
2.	Mallela, Aditya Kumar: 1 article (01/2021)
3.	Penmatsa, Aravind: 1 article (01/2021)
4.	Pidathala, Shabareesh: 1 article (01/2021)
5.	McColl, Eliza R: 1 article (10/2020)
6.	Piquette-Miller, Micheline: 1 article (10/2020)
7.	Hung, Andrew: 1 article (06/2020)
8.	Karagiannis, Tom C: 1 article (06/2020)
9.	Liang, Julia: 1 article (06/2020)
10.	Pitsillou, Eleni: 1 article (06/2020)

Related Diseases

1.	Epilepsy (Aura) 01/01/2016 - "The SLCs identified were either metal ion exchangers or neurotransmitter transporters, which are likely to play a part in epilepsy by influencing neuronal excitability. " 11/01/2004 - "A dysfunction of amino acid neurotransmitter transporters occurs in a number of central nervous system disorders, including stroke, epilepsy, cerebral palsy and amyotrophic lateral sclerosis. " 01/01/2007 - "Recent progress in ion channel research brought about by molecular cloning of the channel subunit proteins and studies in epilepsy models suggest additional targets, including G-protein-coupled receptors, such as GABA(B) and metabotropic glutamate receptors; hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channel subunits, responsible for hyperpolarization-activated current Ih; connexins, which make up gap junctions; and neurotransmitter transporters, particularly plasma membrane and vesicular transporters for GABA and glutamate. "
2.	Neurodegenerative Diseases (Neurodegenerative Disease) 01/01/2018 - "Results of the study performed by using genetic methods developed by the authors for the study of neurotransmitter transporters make it possible to recommend these methods to control the neurogenesis and neurohomeostasis, including in cerebrovascular and neurodegenerative diseases. " 03/31/1993 - "There is evidence suggesting neurotransmitter transporters to be involved in the pathophysiology of certain neurodegenerative diseases, and there are indications that drugs affecting transporter proteins may assume increasing clinical importance."
3.	Nervous System Diseases (Neurological Disorders) 09/01/1996 - "[Neurotransmitter transporters--a role of the molecular mechanism in nervous system diseases and drug poisoning]." 01/01/2016 - "Various psychostimulants targeting monoamine neurotransmitter transporters (MATs) have been shown to rescue cognition in patients with neurological disorders and improve cognitive abilities in healthy subjects at low doses. "
4.	Mental Disorders (Mental Disorder) 09/01/2012 - "Pharmacological inhibition of the neurotransmitter transporters in this family is an important strategy in the management of neurological and psychiatric disorders. " 05/07/2018 - "Sodium (Na+) acts as an indispensable allosteric regulator of the activities of biologically important neurotransmitter transporters and G-protein coupled receptors (GPCRs), which comprise well-known drug targets for psychiatric disorders and addictive behavior. "
5.	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 11/04/2003 - "Neurotransmitter transporters are the target of various pharmacological agents used to treat psychological or cognitive conditions, such as depression and attention-deficit disorder. " 12/23/2005 - "The evidence suggests that ADHD is primarily a polygenic disorder involving at least 50 genes, including those encoding enzymes of neurotransmitter metabolism, neurotransmitter transporters and receptors. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)
3.	Glutamic Acid (Glutamate)
4.	gamma-Aminobutyric Acid (GABA)
5.	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
6.	Connexins
7.	Cyclic Nucleotides
8.	Ion Channels (Ion Channel)
9.	Cations
10.	Enzymes