Monckeberg Medial Calcific Sclerosis

Thickening and loss of elasticity of the walls of muscular ARTERIES due to calcification of the TUNICA MEDIA, the concentric layers of helically arranged SMOOTH MUSCLE CELLS.

Also Known As:

Medial Calcific Sclerosis; Monckeberg's Medial Calcific Sclerosis; Monckeberg's Sclerosis; Mönckeberg Medial Calcific Sclerosis; Mönckeberg's Medial Calcific Sclerosis; Mönckeberg's Sclerosis; Sclerosis, Monckeberg Medial Calcific; Sclerosis, Mönckeberg Medial Calcific; Calcific Scleroses, Medial; Calcific Sclerosis, Medial; Medial Calcific Scleroses; Monckeberg Sclerosis; Monckebergs Sclerosis; Mönckeberg Sclerosis; Mönckebergs Sclerosis; Scleroses, Medial Calcific; Sclerosis, Medial Calcific; Sclerosis, Monckeberg's; Sclerosis, Mönckeberg's

Networked: 15 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10142
  - Calcium Metabolism Disorders: 47
    - Calcinosis: 1855
      - Vascular Calcification: 3514
        Monckeberg Medial Calcific Sclerosis: 15

Related Diseases

1.	Arterial Occlusive Diseases (Arterial Occlusive Disease)
2.	Vascular Calcification
3.	Neointima
4.	Atherosclerotic Plaque (Atheroma)
5.	Chronic Renal Insufficiency

Experts

1.	Lei, Yang: 2 articles (12/2014 - 11/2013)
2.	Vyavahare, Naren: 2 articles (12/2014 - 11/2013)
3.	Baselli, Giuseppe: 1 article (05/2021)
4.	Capra, Davide: 1 article (05/2021)
5.	Codari, Marina: 1 article (05/2021)
6.	Cozzi, Andrea: 1 article (05/2021)
7.	Di Leo, Giovanni: 1 article (05/2021)
8.	Monti, Caterina Beatrice: 1 article (05/2021)
9.	Nenna, Carolina: 1 article (05/2021)
10.	Sardanelli, Francesco: 1 article (05/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Monckeberg Medial Calcific Sclerosis:

1.	CalciumIBA 01/01/2008 - "Arterial calcification in patients with chronic kidney disease can result from the deposition of mineral along the intimal layer of arteries in conjunction with atheromatous plaques or from calcium deposition in the medial wall of arteries, also known as Monckeberg's sclerosis. " 01/01/1998 - "Experiments on rats (single-action, six-days' hyperepinephrinemia and monoiodacetatic acid intoxication) were performed to study the calcium concentration, alkaline phosphatase and gamma-glutamyltransferase activities in serum at Monckeberg's medial calcific sclerosis modelment. "
2.	gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)IBA 01/01/1998 - "Experiments on rats (single-action, six-days' hyperepinephrinemia and monoiodacetatic acid intoxication) were performed to study the calcium concentration, alkaline phosphatase and gamma-glutamyltransferase activities in serum at Monckeberg's medial calcific sclerosis modelment. "
3.	Alkaline PhosphataseIBA 01/01/1998 - "Experiments on rats (single-action, six-days' hyperepinephrinemia and monoiodacetatic acid intoxication) were performed to study the calcium concentration, alkaline phosphatase and gamma-glutamyltransferase activities in serum at Monckeberg's medial calcific sclerosis modelment. "
4.	AcidsIBA 01/01/1998 - "Experiments on rats (single-action, six-days' hyperepinephrinemia and monoiodacetatic acid intoxication) were performed to study the calcium concentration, alkaline phosphatase and gamma-glutamyltransferase activities in serum at Monckeberg's medial calcific sclerosis modelment. "
5.	Proteins (Proteins, Gene)FDA Link 11/23/1999 - "Medial localization of mineralization-regulating proteins in association with Mönckeberg's sclerosis: evidence for smooth muscle cell-mediated vascular calcification." 05/01/2013 - "We conclude that vitamin K antagonists inhibit several proteins which protect the vessels from calcification leading to medial calcific sclerosis."
6.	ElastinIBA 12/28/2014 - "Elastin-specific medial arterial calcification (MAC) is an arterial disease commonly referred as Monckeberg's sclerosis. " 11/01/2013 - "Elastin-specific medial vascular calcification, termed "Monckeberg's sclerosis," has been recognized as a major risk factor for various cardiovascular events. "
7.	RANK LigandIBA 08/01/2004 - "Localization of osteoprotegerin, tumor necrosis factor-related apoptosis-inducing ligand, and receptor activator of nuclear factor-kappaB ligand in Mönckeberg's sclerosis and atherosclerosis."
8.	OsteoprotegerinIBA 08/01/2004 - "Localization of osteoprotegerin, tumor necrosis factor-related apoptosis-inducing ligand, and receptor activator of nuclear factor-kappaB ligand in Mönckeberg's sclerosis and atherosclerosis."
9.	Biomarkers (Surrogate Marker)IBA 05/01/2021 - "Breast arterial calcifications (BAC), representing Mönckeberg's sclerosis of the tunica media of breast arteries, are an imaging biomarker for cardiovascular risk stratification in the female population. "
10.	Vitamin K FDA Link 05/01/2013 - "In certain patients, even at low vascular risk, a medial calcific sclerosis can appear under long-term anticoagulation with vitamin K antagonists. " 05/01/2013 - "[Medial calcific sclerosis under long-term anticoagulation with vitamin K antagonists]." 05/01/2013 - "We conclude that vitamin K antagonists inhibit several proteins which protect the vessels from calcification leading to medial calcific sclerosis."

Therapies and Procedures

1.	Sympathectomy (Sympathectomies) 05/01/1983 - "Sixty patients (19 diabetic and 41 non-diabetic) were examined radiologically for typical Mönckeberg's sclerosis of feet arteries 6-8 years after uni- or bilateral lumbar sympathectomy. " 05/01/1983 - "Mönckeberg's sclerosis after sympathetic denervation in diabetic and non-diabetic subjects." 04/04/1991 - "The failing long-term efficacy of lumbar sympathectomy in critical arterial limb disease may be explained by marked spontaneous sympathicolysis in diabetics, whereas in non-diabetics with sympathetic activation other mechanisms like development of unilateral Mönckeberg sclerosis, progression of proximal arterial occlusion or induction of steal effects have to be discussed." 05/01/1983 - "In conclusion, sympathetic denervation is one of the causes of Mönckeberg's sclerosis regardless of diabetes mellitus."
2.	Free Tissue Flaps 11/01/2014 - "All the selectable Mesh headings for "Monckeberg's sclerosis" and "free flap" were included. " 11/01/2014 - "The following terms was added to the search builder: Monckeberg's sclerosis, free flap. "
3.	Knee Replacement Arthroplasty (Total Knee Replacement) 04/01/2004 - "Popliteal artery rupture during total knee replacement in a patient with Mönckeberg's sclerosis. "
4.	Therapeutics 04/01/2014 - "Role of sodium thiosulfate therapy in the treatment of digital necrosis due to Mönckeberg sclerosis."
5.	Ligation 08/01/2004 - "Apoptosis, which precedes vascular calcification in vitro, was assessed by an in situ ligation assay and was localized to the medial layer of arteries (Mönckeberg's sclerosis) and the neointima (atherosclerosis). "