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Oncolytic Virotherapy

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Use of attenuated VIRUSES as ANTINEOPLASTIC AGENTS to selectively kill CANCER cells.

Also Known As:

Oncolytic Virus Therapy; Virotherapy, Oncolytic; Oncolytic Virotherapies; Oncolytic Virus Therapies; Therapies, Oncolytic Virus; Therapy, Oncolytic Virus; Virotherapies, Oncolytic; Virus Therapies, Oncolytic; Virus Therapy, Oncolytic

Networked: 311 relevant articles (43 outcomes, 25 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 15318
- Biological Therapy: 2317
  - Oncolytic Virotherapy: 311

Experts

1.	Szalay, Aladar A: 16 articles (12/2015 - 01/2009)
2.	McFadden, Grant: 14 articles (08/2015 - 02/2007)
3.	Russell, Stephen J: 13 articles (08/2015 - 12/2002)
4.	Fujiwara, Toshiyoshi: 11 articles (01/2013 - 03/2007)
5.	Chen, Nanhai G: 9 articles (12/2015 - 01/2012)
6.	Lesniak, Maciej S: 8 articles (04/2015 - 05/2007)
7.	Bell, John C: 8 articles (03/2014 - 09/2007)
8.	Melcher, Alan: 8 articles (07/2013 - 01/2008)
9.	Todo, Tomoki: 7 articles (06/2015 - 09/2002)
10.	Weibel, Stephanie: 7 articles (01/2015 - 01/2012)

Related Diseases

1.	Neoplasms (Cancer) 07/15/2003 - "Efficient distribution to the tumor site may be one of the most critical parameters for antitumor efficacy with oncolytic virotherapy." 01/01/2015 - "More recently however, a new paradigm has developed in the oncolytic virotherapy field stating that oncolytic virus-mediated tumor cell death can be accompanied by elicitation of potent activation of innate and adaptive anti-tumor immunity that greatly improves the efficacy of certain oncolytic strains. " 06/01/2013 - "Combination of oncolytic virotherapy with radioiodine treatment (radiovirotherapy) led to an additional reduction of tumor growth that resulted in markedly improved survival as compared with virotherapy alone. " 03/01/2012 - "Although the immune response to oncolytic viruses can rapidly restrict viral replication, thereby limiting the efficacy of therapy, oncolytic virotherapy also has the potential to induce potent antitumoural immune effectors that destroy those cancer cells, which are not directly lysed by virus. " 10/01/2010 - "As they modulate genes which lead to enhanced chemosensitivity, immunogenicity or dampened innate antiviral response of cancer cells, epigenetic drugs often show better efficacy when combined with chemotherapy, immunotherapy or oncolytic virotherapy. "
2.	Infection 01/01/2015 - "Adenoviruses (Ads) are most commonly used for oncolytic virotherapy due to their infection efficacy, high titer production, safety, easy genetic modification, and well-studied replication characteristics. " 05/01/2012 - "This observation, that KG-1 can be targeted in vivo even in the absence of in vitro permissive viral infection, contrasts with the current understanding of oncolytic virotherapy, which assumes that virus infection and productive replication is a requirement. " 01/01/2011 - "It may be useful to enhance the efficiency of HSV-1 infection in oncolytic virotherapy." 06/01/2010 - "We believe this is the first example of a virus/cell-based "pharmacoviral" screen aimed to identify small molecules that modulate cellular response to virus infection and enhance oncolytic virotherapy." 01/01/2008 - "Current oncolytic virotherapy strategies are based in the accumulated understanding of the common molecular mechanisms displayed during cell transformation and viral infection, like cell cycle and apoptosis deregulations. "
3.	Pancreatic Neoplasms (Pancreatic Cancer) 09/01/2005 - "The eligibility and feasibility of oncolytic virus therapy as a novel therapeutic agent against pancreatic cancer are discussed as well as basic research for clinical trials, including a historical perspective and the current status of these novel agents. " 03/01/2011 - "To examine the efficacy of oncolytic virus therapy for pancreatic cancer, we initiated pilot studies by injecting six patients with non-resectable pancreatic cancer with three doses of HF10. " 01/01/2011 - "Oncolytic virotherapy for pancreatic cancer." 09/01/2005 - "Oncolytic virus therapy certainly appears to be a feasible treatment for pancreatic cancer." 09/01/2005 - "The potential of oncolytic virus therapy for pancreatic cancer."
4.	Glioblastoma (Glioblastoma Multiforme) 01/01/2013 - "The results also point to the intriguing possibility of using this virus for studies to develop oncolytic virus therapy approaches against glioblastoma, a highly aggressive malignancy. " 01/01/2015 - "Oncolytic virotherapy is a novel approach for the treatment of glioblastoma multiforme (GBM) which is still a fatal disease. " 07/16/2013 - "Multifaceted oncolytic virus therapy for glioblastoma in an immunocompetent cancer stem cell model." 06/01/2012 - "Oncolytic virotherapy is a promising novel therapy for glioblastoma that needs to be optimized before introduced to clinic. " 01/01/2012 - "Oncolytic virus therapy for glioblastoma multiforme: concepts and candidates."
5.	Glioma (Gliomas) 12/15/2014 - "Oncolytic virus therapy is being evaluated in clinical trials for human glioma. " 08/01/2015 - "Oncolytic virotherapy uses replication-competent viruses to target and kill malignant cells and has been evaluated in clinic for glioma therapy with limited results. " 04/01/2015 - "Unlocking the promise of oncolytic virotherapy in glioma: combination with chemotherapy to enhance efficacy." 01/01/2015 - "The role of the immune system in oncolytic virotherapy for glioma remained much less studied until recent years. " 01/01/2015 - "Immune Suppression during Oncolytic Virotherapy for High-Grade Glioma; Yes or No?"

Related Drugs and Biologics

1.	Sirolimus (Rapamycin)
2.	Vaccines
3.	Neutralizing Antibodies
4.	eIF-2 Kinase (eIF 2 Kinase)
5.	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
6.	Hyaluronic Acid (Hyaluronan)
7.	2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH)
8.	pyropheophorbide a
9.	pppA(2'p5'A)n-dependent ribonuclease (RNase L)
10.	1-phenyl-3,3-dimethyltriazene (PDT)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Immunotherapy
4.	Therapeutics
5.	Radiotherapy