TRPC Cation Channels

A subgroup of TRP cation channels that contain 3-4 ANKYRIN repeats and a conserved C-terminal domain. Members are highly expressed in the CENTRAL NERVOUS SYSTEM. Selectivity for calcium over sodium ranges from 0.5 to 10.

Also Known As:

Networked: 108 relevant articles (1 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Szallasi, Arpad: 4 articles (05/2014 - 01/2009)
2.	Kitamoto, Toshihiro: 4 articles (01/2014 - 03/2010)
3.	Holzer, Peter: 3 articles (05/2014 - 01/2011)
4.	Sato, Shoma: 3 articles (01/2014 - 01/2012)
5.	Sakai, Takaomi: 3 articles (01/2014 - 01/2012)
6.	Liberati, Sonia: 3 articles (03/2013 - 01/2012)
7.	Santoni, Giorgio: 3 articles (01/2013 - 03/2011)
8.	Voets, Thomas: 3 articles (01/2013 - 08/2005)
9.	Eroglu, S: 2 articles (12/2015 - 04/2015)
10.	Becker, Esther B E: 2 articles (07/2015 - 07/2015)

Related Diseases

1.	Ganglion Cysts (Ganglion) 01/01/2013 - "These ganglion-to-ganglion differences in TRP channel transcript levels may contribute to the variability in sensory responses in functional studies. " 01/01/2013 - "Notably, four TRP channels, TRPC4, TRPM4, TRPM8 and TRPV1, showed statistically significant variation in mRNA levels between DRGs from different segments, suggesting ganglion-specific regulation of TRP channel gene expression. " 01/01/2013 - "We developed, compared and refined techniques to quantitatively analyse the relative mRNA expression of all TRP channel genes at the single ganglion level. " 01/01/2013 - "At the mRNA level, 17 of the 28 TRP channel genes, TRPA1, TRPC1, TRPC3, TRPC4, TRPC5, TRPM2, TRPM3, TRPM4, TRPM5, TRPM6, TRPM7, TRPM8, TRPV1, TRPV2, TRPV4, TRPML1 and TRPP2, were detectable in every tested ganglion. "
2.	Pain (Aches) 01/11/2012 - "In this study we attempted to address this question using six sensory neuronal TRP channel-expressing heterologous systems, cultured sensory neurons and TRP-mediated acute animal pain tests. " 07/01/2009 - "In this study, we report a novel role of the Pain TRP channel expressed in the nervous system in the sexual receptivity in Drosophila virgin females. " 03/01/2015 - "In conclusion, distinct members of TRP channel family are involved in different pain models in mice. " 01/01/2014 - "Painless (Pain) is the Drosophila TRP channel that was initially identified as a molecular sensor responsible for detecting noxious thermal and mechanical stimuli. " 01/01/2014 - "ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons."
3.	Neoplasms (Cancer) 01/01/2013 - "We are only at the beginning, and more detailed study on the physiopathologic role of TRP channels is required to understand how the deregulation of TRP channel expression and function contributes to tumor development and progression. " 12/01/2014 - "We focus on how TRP channel or STIM/ORAI-mediated Ca(2+) signalling directly or indirectly influences cancer and stroma cell migration by affecting the above listed mechanisms. " 11/01/2014 - "Transient receptor protein (TRP) channels are frequently associated with tumors and are correlated to patient's outcome. " 05/01/2014 - "Indeed, there is growing evidence that TRP channel expression is altered in cancer tissues in comparison with normal ones. " 05/01/2012 - "Several members of the transient receptor potential (TRP)-channel family are expressed in cancer cells. "
4.	Inflammation 01/01/2013 - "In the context of respiratory disease however TRP channel function may be altered, eg: under conditions of oxidative stress, inflammation, hypoxia and mechanical stress. " 01/01/2013 - "These substances can affect TRP channel functions and lead to the progression of diseases such as inflammation and chronic pain. " 01/01/2012 - "Therapeutically, manipulation of TRP channel activity may represent an effective strategy to treat peripheral pain associated with inflammation and chronic tissue injury." 04/01/2011 - "The extent of inflammation, pancreatic neuron TRP channel expression and function and excitability, and pain-related behaviors were evaluated over the course of the following week. " 11/01/2012 - "Although the functional significance of urinary bladder TRP channel plasticity awaits further investigation, these studies demonstrate context- (inflammation, postnatal development, NGF-OE, VIP deletion) and tissue-dependent (urothelium + suburothelium, detrusor) plasticity."
5.	Melanoma (Melanoma, Malignant) 08/01/1997 - "Most of our knowledge of the mammalian tyrosinase related protein (TRP) activities is derived from studies using murine melanoma models, such as B16 or Cloudman S-91 melanocytes. " 01/15/2000 - "Vaccination against murine tyrosinase-related protein (TRP)-1/gp75 was shown recently to cause melanoma rejection, which was accompanied by autoimmune skin depigmentation (vitiligo). " 09/01/2010 - "Melanocyte differentiation Ags, including tyrosinase-related protein (TRP) 1, are relevant to both autoimmune skin depigmentation (vitiligo) and tumor immunity, because they are expressed by both benign melanocytes and many malignant melanomas. " 12/15/2000 - "Tyrosinase-related protein (TRP) 2 belongs to the melanocyte differentiation antigens and has been implicated as a target for immunotherapy of human as well as murine melanoma. " 12/06/1999 - "We have shown previously that active immunization of mice against the melanocyte differentiation antigen, a tyrosinase-related protein (TRP) gp75(TRP-1) (the brown locus protein) expressed by melanomas, could induce tumor immunity and autoimmunity manifested as depigmentation. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Nerve Growth Factor (NGF)
3.	Monophenol Monooxygenase (Tyrosinase)
4.	rho-Associated Kinases
5.	N-Methylaspartate (NMDA)
6.	Nitric Oxide (Nitrogen Monoxide)
7.	Bradykinin
8.	icilin
9.	Y 27632
10.	fasudil (AT 877)

Related Therapies and Procedures

1.	Therapeutics
2.	Surgical Instruments (Clip)
3.	Immunotherapy