Primary Hyperparathyroidism

A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.
Also Known As:
Hyperparathyroidism, Primary; Hyperparathyroidisms, Primary; Primary Hyperparathyroidisms
Networked: 3073 relevant articles (125 outcomes, 312 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Parathyroid Neoplasms (Parathyroid Neoplasm)
2. Hypercalcemia (Milk Alkali Syndrome)
3. Multiple Endocrine Neoplasia Type 1 (MEN I)
4. Neoplasms (Cancer)
5. Osteoporosis


1. Chen, Herbert: 39 articles (10/2015 - 08/2002)
2. Sippel, Rebecca S: 26 articles (10/2015 - 01/2004)
3. Bilezikian, John P: 20 articles (11/2014 - 10/2003)
4. Silverberg, Shonni J: 19 articles (12/2015 - 04/2002)
5. Perrier, Nancy D: 17 articles (06/2014 - 06/2003)
6. Duh, Quan-Yang: 16 articles (01/2014 - 08/2003)
7. Irvin, George L: 16 articles (12/2011 - 08/2002)
8. Udelsman, Robert: 14 articles (11/2014 - 05/2002)
9. Solorzano, Carmen C: 14 articles (03/2011 - 12/2003)
10. Lew, John I: 13 articles (12/2015 - 07/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Primary Hyperparathyroidism:
1. CalciumIBA
2. Parathyroid Hormone (Parathormone)IBA
3. cinacalcet (Sensipar)FDA Link
4. Technetium Tc 99m Sestamibi (Cardiolite)FDA LinkGeneric
5. Vitamin DFDA LinkGeneric
6. DiphosphonatesIBA
7. Sodium Pertechnetate Tc 99m (Pertechnetate)FDA Link
09/01/2001 - "The main purposes of this study were: (a) to investigate the efficacy of an imaging protocol based on the combination of 99mTcO4/MIBI scintigraphy and neck ultrasound (US) in selecting patients with primary hyperparathyroidism (HPT) for unilateral neck exploration, and (b) to help define the role of the intraoperative MIBI gamma probe (IMGP) technique in the performance of minimally invasive radio-guided surgery (MIRS). "
09/01/2000 - "The aims of this study were: (a) to define the accuracy of a preoperative parathyroid imaging protocol based on the combination of technetium-99m pertechnetate/technetium-99m methoxyisobutylisonitrile (99mTcO4/ 99mTc-MIBI) scan and neck ultrasound (US) in selecting patients with primary hyperparathyroidism (pHPT) eligible for a limited neck exploration, and (b) to investigate the potential role of the intraoperative gamma probe (IGP) in radio-guided minimally invasive surgery. "
12/12/1992 - "The aim of this study was to evaluate the use of scintigraphy with thallium-201 chloride (201 Tl) and technetium-99m pertechnetate (99mTc) in the diagnosis of the localization of the pathological parathyroid glands in primary hyperparathyroidism and compare the results with those of high resolution ultrasonography. "
07/01/2014 - "Comparison of Tc-99m pertechnetate images with dual-phase Tc 99m MIBI and SPECT images in primary hyperparathyroidism."
03/01/2008 - "A combination of planar 99mTc-MIBI/99mTcO4- scintigraphy and P-SPECT appears to be a highly accurate preoperative imaging procedure in primary hyperparathyroidism."
8. hydroxide ionIBA
9. 25-hydroxyvitamin DIBA
10. HormonesIBA

Therapies and Procedures

1. Parathyroidectomy
2. Hormone Replacement Therapy (Therapy, Hormone Replacement)
3. Anesthesia
4. Sternotomy
5. Local Anesthesia