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Lysophosphatidic Acid Receptors

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A subfamily of lysophospholipid receptors with specificity for LYSOPHOSPHATIDIC ACIDS.

Also Known As:

Receptors, Lysophosphatidic Acid; EDG7 Protein; Edg-4 Receptor; Edg-7 Receptor; Edg2 Protein; Edg4 Protein; LPA Receptors; LPA-1 Receptor; LPA1 Receptor; LPA2 Receptor; LPA3 Receptor; Receptor, Lysophosphatidic Acid; edg-2 Receptor; vzg-1 Receptor; Acid Receptor, Lysophosphatidic; Acid Receptors, Lysophosphatidic; Edg 4 Receptor; Edg 7 Receptor; LPA 1 Receptor; Receptor, Edg-4; Receptor, Edg-7; Receptor, LPA1; Receptor, LPA2; Receptor, LPA3; Receptor, edg-2; Receptor, vzg-1; Receptors, LPA; edg 2 Receptor; vzg 1 Receptor; Lysophosphatidic Acid Receptor

Networked: 196 relevant articles (3 outcomes, 22 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Membrane Proteins: 5300
    - Cell Surface Receptors: 753
      - G-Protein-Coupled Receptors: 810
        Lysophospholipid Receptors: 5
        Lysophosphatidic Acid Receptors: 196
        human GPR45 protein
        human GPR87 protein
        human LPAR5 protein
        human LPAR6 protein
        mouse GPR87 protein
        mouse LPAR5 protein

Experts

1.	Chun, Jerold: 25 articles (09/2015 - 07/2004)
2.	Tsujiuchi, Toshifumi: 11 articles (08/2014 - 01/2010)
3.	Fukushima, Nobuyuki: 11 articles (08/2014 - 01/2010)
4.	Ueda, Hiroshi: 10 articles (08/2013 - 07/2004)
5.	Mills, Gordon B: 10 articles (01/2010 - 03/2004)
6.	Tigyi, Gabor: 9 articles (02/2015 - 08/2003)
7.	Aoki, Junken: 9 articles (05/2014 - 01/2004)
8.	Im, Dong-Soon: 7 articles (02/2014 - 03/2007)
9.	Peyruchaud, Olivier: 6 articles (05/2015 - 12/2004)
10.	Fujiwara, Yuko: 6 articles (02/2015 - 08/2006)

Related Diseases

1.	Fibrosis (Cirrhosis) 05/27/2011 - "Blockade of lysophosphatidic acid receptors LPAR1/3 ameliorates lung fibrosis induced by irradiation." 12/01/2013 - "However, the role of other LPA receptors in fibrosis remains unclear. " 05/01/2011 - "Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma." 12/01/2007 - "Therefore, the LPA1 receptor might be a pharmaceutical target to treat renal fibrosis." 12/01/2007 - "LPA1 receptor activation promotes renal interstitial fibrosis."
2.	Inflammation 01/01/2009 - "These results suggest that LPA and LPA receptors are involved in Schistosoma mansoni egg-mediated inflammation and further studies are proposed to understand the role of LPA and LPA receptors in the inflammatory process." 08/01/2015 - "A transgenic mouse model for the in vivo bioluminescence imaging of the expression of the lysophosphatidic acid receptor 3: relevance for inflammation and uterine physiology research." 10/01/2011 - "Here, we demonstrate that LPA receptors contribute to lipopolysaccharide (LPS)-induced inflammation. " 10/01/2011 - "Lysophosphatidic acid receptor 1 modulates lipopolysaccharide-induced inflammation in alveolar epithelial cells and murine lungs." 01/01/2009 - "Here we provide evidence for the role of LPA and LPA receptors in Th2-dominant airway inflammation. "
3.	Lung Injury 03/01/2012 - "The lysophosphatidic acid receptor LPA1 promotes epithelial cell apoptosis after lung injury." 01/01/2008 - "The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak." 04/01/2009 - "Finally, we show that the expression levels of both the LPA2 receptor and alphavbeta6 integrin are up-regulated and are spatially and temporally associated following bleomycin-induced lung injury. " 08/01/2010 - "These findings demonstrate that AM966 is a potent, selective, orally bioavailable LPA(1) receptor antagonist that may be beneficial in treating lung injury and fibrosis, as well as other diseases that are characterized by pathological inflammation, oedema and fibrosis." 07/01/2015 - "Lysophosphatidic acid (LPA) is a bioactive lipid mediator of inflammation via the LPA receptors 1-6. We and others have previously described proinflammatory and profibrotic activities of LPA signaling in bleomycin- or lipopolysaccharide (LPS)-induced pulmonary fibrosis or lung injury models. "
4.	Neoplasms (Cancer) 06/01/2014 - "In recent studies, it has been demonstrated that LPA receptors have the diverse effects in the cell motile activities of cancer cells, depending on the cell types involved. " 03/01/2014 - "So far, numerical studies have demonstrated that LPA signaling via LPA receptors contributes to the acquisition of malignant potency by several cancer cells. " 08/01/2012 - "In this study, to evaluate an involvement of LPA receptors on angiogenic process in mammary tumor cells, we generated Lpar1- and Lpar3-expressing (FM3A-a1 and FM3A-a3A9, respectively) cells from FM3A cells, and investigated the effects on cell proliferation and migration abilities of endothelial F-2 cells by those cells. " 06/01/2010 - "Because LPA receptors and ATX are currently being targeted in preclinical trials, the current findings should stimulate future studies to evaluate the expression pattern and clinical outcome of LPA(4), together with other LPA receptors, in various cancer patients." 08/01/2015 - "Aberrant expression and potential therapeutic target of lysophosphatidic acid receptor 3 in triple-negative breast cancers."
5.	Neoplasm Metastasis (Metastasis) 06/02/2009 - "Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases." 06/01/2008 - "Thus the LPA(2) and LPA(3) receptors, in addition to the previously implicated LPA(1) receptor, play a role in cellular motility potentially contributing to invasion and metastases. " 12/15/2007 - "Nm23-H1 suppresses metastasis by inhibiting expression of the lysophosphatidic acid receptor EDG2." 06/20/2006 - "The type 1 lysophosphatidic acid receptor is a target for therapy in bone metastases." 07/01/2012 - "The present study evaluated the potential role of lysophosphatidic acid receptors (lpars) in processes leading to local invasiveness and metastasis in Chinese pancreatic carcinoma. "

Related Drugs and Biologics

1.	3- (4- (4- ((1- (2- chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid
2.	lysophosphatidic acid (MOPA)
3.	Lysophosphatidic Acid Receptors
4.	GTP-Binding Proteins (G-Protein)
5.	Small Interfering RNA (siRNA)
6.	Proteins (Proteins, Gene)
7.	Interleukin-8 (Interleukin 8)
8.	Enzymes
9.	Cytokines
10.	Interleukin-6 (Interleukin 6)

Related Therapies and Procedures

1.	Chemoprevention
2.	Heterologous Transplantation (Xenotransplantation)
3.	Intradermal Injections