Mongolian Spot

A bluish-gray to gray-brown benign, melanocytic nevus found usually in the LUMBOSACRAL REGION of dark-skinned people, especially those of East Asian ancestry. It is usually congenital or appears shortly after birth, and disappears in childhood.

Also Known As:

Networked: 15 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Nevus (Nevi)
2.	Port-Wine Stain (Nevus Flammeus)
3.	Hyperpigmentation
4.	Neurocutaneous Syndromes (Phakomatoses)
5.	Nevus of Ota

Experts

1.	Happle, Rudolf: 2 articles (07/2012 - 02/2008)
2.	Lu, Chun: 1 article (05/2015)
3.	Liao, Mengsi: 1 article (05/2015)
4.	Lu, Rongbiao: 1 article (05/2015)
5.	Qiu, Shu: 1 article (05/2015)
6.	Ma, Han: 1 article (05/2015)
7.	Luo, Ruijun: 1 article (05/2015)
8.	Abrahám, Rita: 1 article (03/2014)
9.	Gyurkovits, Zita: 1 article (03/2014)
10.	Bakki, Judit: 1 article (03/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mongolian Spot:

1.	styrene-methylmethacrylate copolymerIBA 03/30/2014 - "The most common vascular lesions were naevus simplex, haemangioma and haemangioma precursor lesion, while the most frequently observed pigmented lesions were congenital melanocytic naevi and Mongolian spot. " 09/01/2008 - "Mongolian spot and nevus simplex were the two most common congenital lesions in the present study. "
2.	Phacomatosis pigmentovascularisIBA 11/01/2013 - "A case of a 2-year-old patient is reported, who presented extensive nevus flammeus and an aberrant Mongolian spot, without systemic disease, manifestations that allow us to classify this case as type IIa Phacomatosis Pigmentovascularis, according to Hasegawa's classification." 07/01/2012 - "Phacomatosis pigmentovascularis (PPV) represents a group of different types of didymosis (twin spotting) characterized by the coexistence of a large pigmentary nevus such as a mongolian spot, café-au-lait macule or macular nevus spilus, and an extensive telangiectatic nevus, such as nevus flammeus or nevus roseus. " 09/01/1997 - "The association of nevus flammeus with mongolian spot, nevus fuscoceruleus, nevus spilus and, with variable frequency, with nevus anemicus has been termed phacomatosis pigmentovascularis, a genodermatosis first described by Ota and co-workers. " 05/01/2015 - "We discuss an entirely unique case of Phacomatosis pigmentovascularis with nevus of Ota, extensive Mongolian spot, nevus flammeus, nevus anemicus and cutis marmorata telangiectatica congenita, which may represent a heretofore undescribed variant of phacomatosis pigmentovascularis. " 05/01/2015 - "The case of a boy with nevus of Ota, extensive Mongolian spot, nevus flammeus, nevus anemicus and cutis marmorata telangiectatica congenita: a unique instance of phacomatosis pigmentovascularis."
3.	Carbon MonoxideIBA 02/15/2008 - "Phacomatosis cesioflammea is characterized by the co-existence of a large nevus cesius (i.e., aberrant Mongolian spot, or nevus fuscocoeruleus) and an extensive nevus flammeus (i.e., port-wine stain). " 09/01/1997 - "The association of nevus flammeus with mongolian spot, nevus fuscoceruleus, nevus spilus and, with variable frequency, with nevus anemicus has been termed phacomatosis pigmentovascularis, a genodermatosis first described by Ota and co-workers. "
4.	Cutis marmorata telangiectatica congenitaIBA 05/01/2007 - "An infant with extensive Mongolian spot, naevus flammeus and cutis marmorata telangiectatica congenita: a unique case of phakomatosis pigmentovascularis." 05/01/2015 - "We discuss an entirely unique case of Phacomatosis pigmentovascularis with nevus of Ota, extensive Mongolian spot, nevus flammeus, nevus anemicus and cutis marmorata telangiectatica congenita, which may represent a heretofore undescribed variant of phacomatosis pigmentovascularis. " 05/01/2015 - "The case of a boy with nevus of Ota, extensive Mongolian spot, nevus flammeus, nevus anemicus and cutis marmorata telangiectatica congenita: a unique instance of phacomatosis pigmentovascularis."
5.	Phosphopyruvate Hydratase (Enolase)IBA 01/01/1986 - "Normal human skin, malignant melanoma, nevocellular nevus, blue nevus, nevus of Ota and mongolian spot were immunohistochemically investigated on the localization of S-100 protein and neuron specific enolase (NSE). "
6.	S100 Proteins (S 100 Protein)IBA 01/01/1986 - "Blue nevus, nevus of Ota and mongolian spot revealed the presence of a small amount of S-100 protein and NSE on the half cases. " 01/01/1986 - "Normal human skin, malignant melanoma, nevocellular nevus, blue nevus, nevus of Ota and mongolian spot were immunohistochemically investigated on the localization of S-100 protein and neuron specific enolase (NSE). "
7.	Minocycline (Cyclops)FDA LinkGeneric 04/01/1992 - "Acquired pseudo-mongolian spot associated with minocycline therapy."
8.	Methoxsalen (Oxsoralen)FDA Link 03/01/1980 - "These include drug-induced hypermelanosis, hypermelanosis secondary to use of physical agents, hypermelanotic morphea, generalized scleroderma with diffuse hypermelanosis, a hyperkeratotic tumor in xeroderma pigmentosum, aberrant mongolian spot, and methoxsalen-ultraviolet-A-induced hypermelanosis. "
9.	Melanins (Melanin)IBA 04/01/1989 - "Blue hyperpigmented disorders may also be melanotic in which there is a normal number of epidermal melanocytes, but melanin pigment is present in the upper dermis (eg, gray/slate pigmentation in Riehl's melanosis), melanocytotic in which melanocytes are present in both the epidermis and dermis (eg, blue pigmentation in Nevus Ota and Mongolian spot), and nonmelanotic hyperpigmentation in which pigment is present in the deep dermis (eg, blue pigmentation in tattoos). "
10.	Hematoxylin (Haematoxylon)IBA 12/01/2012 - "Histopathologic examination of the pigmented region revealed the typical features of a Mongolian spot in the hematoxylin-eosin stained section. "

Therapies and Procedures

1.

Cesarean Section (Caesarean Section) 07/01/2011 - "The dermatoses with statistical significance were: Mongolian spot and epidermal hyperpigmentation with the non-white newborns; erythema toxicum and cutis marmorata with the white newborns; salmon patch with the female sex; physiologic desquamation with the cesarean section; acrocyanosis with the first pregnancy birth and Bohn's nodules with the vaginal delivery. "