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Acanthoma

A neoplasm composed of squamous or epidermal cells.

Also Known As:

Acanthoma, Degos; Acanthoma, Pilar Sheath; Acanthomas; Acanthomas, Clear Cell; Acanthomas, Pilar Sheath; Clear Cell Acanthoma; Clear Cell Acanthomas; Degos Acanthoma; Pilar Sheath Acanthoma; Pilar Sheath Acanthomas; Acanthoma, Clear Cell

Networked: 62 relevant articles (3 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Neoplasms: 649836
- Neoplasms by Histologic Type: 1
  - Glandular and Epithelial Neoplasms: 332
    - Squamous Cell Neoplasms: 1188
      - Acanthoma: 62
- Neoplasms by Site: 1
  - Skin Neoplasms: 4852
    - Acanthoma: 62

Related Diseases

1.	Pruritus (Itching)
2.	Squamous Cell Carcinoma (Epidermoid Carcinoma)
3.	Keratoacanthoma
4.	Basal Cell Carcinoma (Rodent Ulcer)
5.	Psoriasis (Pustulosis Palmaris et Plantaris)

Experts

1.	Romanucci, Mariarita: 2 articles (02/2013 - 10/2008)
2.	Bongiovanni, Laura: 2 articles (02/2013 - 10/2008)
3.	Chi, Ching-Chi: 2 articles (12/2005 - 10/2005)
4.	Wang, Shu-Hui: 2 articles (12/2005 - 10/2005)
5.	Balzer, Bonnie L: 1 article (12/2015)
6.	de Peralta-Venturina, Mariza N: 1 article (12/2015)
7.	Frishberg, David P: 1 article (12/2015)
8.	Mertens, Richard B: 1 article (12/2015)
9.	Suh, Hyun-Jung: 1 article (11/2015)
10.	Yoo, Saejong: 1 article (11/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acanthoma:

1.	NitrogenIBA 02/01/1995 - "We report a patient with multiple lesions demonstrating the typical clinical and histological features of clear cell acanthoma, which responded well to treatment with liquid nitrogen." 11/19/2010 - "Despite significant progress in treatment of clear cell acanthoma, cryotherapy, based on liquid nitrogen, remains an important alternative in treating multiple clear cell acanthomas."
2.	Tacrolimus (Prograf)FDA LinkGeneric 03/01/2014 - "Anogenital epidermolytic acanthomas: effective treatment of pruritus with 0.1% tacrolimus ointment."
3.	Histamine Antagonists (Antihistamines)IBA 03/01/2014 - "We report a 55-year-old man with pruritic anogenital epidermolytic acanthomas that persisted despite various topical and ablative therapies, and whose pruritus was not relieved with emollients and antihistamines. "
4.	EmollientsIBA 03/01/2014 - "We report a 55-year-old man with pruritic anogenital epidermolytic acanthomas that persisted despite various topical and ablative therapies, and whose pruritus was not relieved with emollients and antihistamines. "
5.	AntibodiesIBA 08/01/1995 - "Immunoreactivities of clear cell acanthoma were almost identical to those of normal epidermis, although some antibodies gave a different staining pattern between clear cell acanthoma and normal epidermis. " 06/01/1997 - "In this study, the clinical and epidemiologic characteristics of epidermolytic acanthomas were summarized, and the expression of keratins (using antibodies to K1, K6, K10, K14, K16, and K19) in five solitary epidermolytic acanthomas was determined using immunohistochemistry techniques. " 02/01/2013 - "Ten canine squamous cell carcinomas (SCCs; one with lymph node metastasis), 30 canine hair follicle tumours (six pilomatricomas, eight infundibular keratinizing acanthomas, six trichoepitheliomas and 10 trichoblastomas) and five normal skin samples were investigated by immunohistochemistry using specific anti-vimentin, -cytokeratin, -survivin and -Hsp72 antibodies. " 12/01/1992 - "Antibodies LL001, LL003, BA17, LP34, CAM5.2, and LH1 were found to be reactive in formalin-fixed material and were used to study 23 basal cell carcinomas, 8 squamous cell carcinomas, 5 keratoacanthomas, 5 Bowen's disease, and 6 clear cell acanthomas. " 08/01/1995 - "In this study, seven cases of clear cell acanthoma were analysed by immunohistochemical techniques, using various monoclonal antikeratin antibodies, and antibodies against filaggrin, involucrin and epithelial membrane antigen. "
6.	Keratins (Keratin)IBA 06/01/1997 - "In conclusion, using immunohistochemistry techniques on solitary epidermolytic acanthomas, we were able to demonstrate (1) an abnormality in K1 and K10 expression in the lesional skin as compared to the adjacent, histologically normal-appearing skin and (b) the expression of hyperproliferative keratins not only with the lesional skin, but also in the perilesional normal skin. " 08/01/1995 - "Immunohistochemical characterization of keratin expression in clear cell acanthoma." 01/01/2014 - "The infundibular keratinizing acanthoma (IKA) is a rare epithelial benign keratin-containing neoplasm of hair follicles. " 06/01/1997 - "In this study, the clinical and epidemiologic characteristics of epidermolytic acanthomas were summarized, and the expression of keratins (using antibodies to K1, K6, K10, K14, K16, and K19) in five solitary epidermolytic acanthomas was determined using immunohistochemistry techniques. " 02/01/2013 - "Ten canine squamous cell carcinomas (SCCs; one with lymph node metastasis), 30 canine hair follicle tumours (six pilomatricomas, eight infundibular keratinizing acanthomas, six trichoepitheliomas and 10 trichoblastomas) and five normal skin samples were investigated by immunohistochemistry using specific anti-vimentin, -cytokeratin, -survivin and -Hsp72 antibodies. "
7.	Mucin-1 (CA 15-3 Antigen)IBA 10/01/2013 - "One large cell acanthoma, 7 epidermoid dysplasias, and 4 squamous papillomas were evaluated with microscopy and biomarkers Ki-67, p53, epithelial membrane antigen (EMA), Ber-EP4, AE1, AE3, and 8 individual cytokeratins. " 08/01/1995 - "In this study, seven cases of clear cell acanthoma were analysed by immunohistochemical techniques, using various monoclonal antikeratin antibodies, and antibodies against filaggrin, involucrin and epithelial membrane antigen. "
8.	filaggrinIBA 04/01/1989 - "Most of the benign tumours exhibited an intense filaggrin-positive granular layer identical to the adjacent healthy skin whereas benign conditions such as irritated seborrhoeic keratoses and clear cell acanthomas were completely devoid of filaggrin. " 08/01/1995 - "In this study, seven cases of clear cell acanthoma were analysed by immunohistochemical techniques, using various monoclonal antikeratin antibodies, and antibodies against filaggrin, involucrin and epithelial membrane antigen. "
9.	Formaldehyde (Formol)FDA Link 12/01/1992 - "Antibodies LL001, LL003, BA17, LP34, CAM5.2, and LH1 were found to be reactive in formalin-fixed material and were used to study 23 basal cell carcinomas, 8 squamous cell carcinomas, 5 keratoacanthomas, 5 Bowen's disease, and 6 clear cell acanthomas. "
10.	Fluorescent Dyes (Fluorescent Probes)IBA 01/01/1985 - "For test models for PDT studies in dermatology and plastic surgery with HpD and other fluorochromes, single thickened resistant plaques of psoriasis and the common baso squamous acanthoma (seborrheic warty growth) have been used. "

Therapies and Procedures

1.	Cryotherapy (Therapy, Cold) 11/19/2010 - "We report an unusual case of a healthy 74-year-old male with multiple clear cell acanthoma on the lower extremities treated successfully with cryotherapy. " 09/01/2014 - "Generally, therapy of clear cell acanthoma is oriented towards ablative solutions, such as surgery or cryotherapy. " 03/01/2013 - "A case of multiple facial clear cell acanthomas successfully treated by cryotherapy." 02/01/1995 - "Multiple clear cell acanthomas treated by cryotherapy." 07/01/1989 - "Multiple clear cell acanthomas--treatment by cryotherapy."
2.	Gas Lasers 06/01/2015 - "Clear cell acanthoma on the axilla successfully treated with carbon dioxide laser." 10/01/2005 - "Clear cell acanthoma successfully treated with a carbon dioxide laser."
3.	Transplants (Transplant) 12/01/2005 - "Clear cell acanthoma occurring in a split-thickness skin graft."
4.	Transplantation (Transplant Recipients) 08/01/2011 - "Isolated epidermolytic acanthoma in a renal transplant recipient."
5.	PUVA Therapy 01/01/1986 - "Disseminated epidermolytic acanthoma was observed during PUVA therapy in a patient with Sézary syndrome. "