Seroma

Tumor-like sterile accumulation of serum in a tissue, organ, or cavity. It results from a tissue insult and is the product of tissue inflammation. It most commonly occurs following MASTECTOMY.

Also Known As:

Networked: 2348 relevant articles (154 outcomes, 304 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hematoma
2.	Breast Neoplasms (Breast Cancer)
3.	Infections
4.	Seroma
5.	Hernia (Hernias)

Experts

1.	Mun, Goo-Hyun: 13 articles (01/2021 - 08/2012)
2.	Clemens, Mark W: 11 articles (01/2022 - 05/2013)
3.	Rubin, J Peter: 10 articles (04/2015 - 10/2004)
4.	Pyon, Jai-Kyong: 9 articles (01/2021 - 08/2012)
5.	Kim, John Y S: 9 articles (01/2021 - 06/2011)
6.	Disa, Joseph J: 8 articles (01/2022 - 06/2007)
7.	Mehrara, Babak J: 7 articles (01/2022 - 06/2007)
8.	Yang, Jung Dug: 7 articles (01/2022 - 02/2014)
9.	Kadin, Marshall E: 7 articles (11/2021 - 01/2017)
10.	Karp, Nolan S: 7 articles (08/2021 - 02/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Seroma:

1.	Fibrin Tissue Adhesive (Fibrin Sealant)IBA 03/01/2006 - "The success rate for seroma resolution (100 percent) was significantly greater with fibrin sealant injection in study patients than with serial aspiration alone (23 percent) in control patients (p = 0.0077). " 05/01/2021 - "There was a significant reduction in the incidence of seroma formation favoring the fibrin glue group when compared to the control group (P = 0.022). " 10/01/1988 - "At necropsy on day 5, a significant reduction in the frequency of seroma was noted in the fibrin glue group. " 12/01/2011 - "Combined quilting and fibrin glue was also effective in reducing the average volume of the seroma and total drained volume of the seroma. " 03/01/2006 - "Percutaneous instillation of fibrin sealant may be an effective treatment for refractory donor-site seromas. "
2.	FibrinIBA 01/01/2020 - "Fibrin sealants have been extensively studied for their efficacy in reducing the rates of seroma by sealing the dead space; however, in most studies, the sealants are used with surgical drains. " 12/01/2020 - "Fibrin sealants provide limited benefits in reducing the volume of seroma and the volume and duration of drainage. " 01/01/2020 - "The use of fibrin sealants without surgical drains may increase the rate of seromas. " 12/01/2016 - "Meta-analysis across non-emergency surgical specialties did not show a statistically significant difference in the risk of seroma for fibrin sealants versus standard care in 32 RCTs analysed [n = 3472, odds ratio (OR) 0.84, 95% confidence interval (CI) 0.68 to 1.04; p = 0.13; I2 = 12.7%], but a statistically significant benefit was found on haematoma development in 24 RCTs (n = 2403, OR 0.62, 95% CI 0.44 to 0.86; p = 0.01; I2 = 0%). " 05/28/2013 - "Noninvasive measures such as fibrin-based adhesives have thus far not been able to prevent seroma occurrence effectively. "
3.	TalcFDA Link 03/01/2012 - "Aerosolized talc is an effective and safe pretreatment to prevent seromas and hasten drain removal after axillary dissection." 04/01/1993 - "In this study we investigated whether talc poudrage could prevent the formation of seroma following dissection of the latissimus dorsi muscle in a canine model. " 03/01/2021 - "One case of the chronic seromas was efficiently sclerosed with talc without recurrence in time. " 03/01/2021 - "A sample of 4 g of talcum powder was introduced in the seroma cavity, and a 15-F drain was left in place. " 01/01/2018 - "Medical talc: one cohort study of 74 patients undergoing talc application following pre-peritoneal mesh placement found a significantly decreased rate of seroma formation of 20.8 versus 2.7% (p < 0.001), but a retrospective study including 21 patients with onlay mesh found an increased rate of 76% seroma formation from 9.5% (p = 0.001). "
4.	SteroidsIBA 09/01/2019 - "Therefore, a simple technique known as aspiration and intralesional steroid injection was proposed in this study for the treatment of auricular seroma. " 09/01/2015 - "This study investigated the effect of local steroid administration on seroma formation. " 09/01/2012 - "In the present study, the prophylactic effect of steroids on seroma formation is investigated. " 11/01/2001 - "Conclusions coming out from this study are: 1) early drains removal doesn't increase seroma rate; 2) axillary clearance has to be performed removing en bloc the fatty tissue respecting surgical plains; 3) apply a compressive bandaging; 4) early arm physiotherapy; 5) medication with steroid may reduce the fluid formation." 04/01/2023 - "Many different strategies, including the usage of steroids, have been tried to reduce the incidence of seroma with varying outcomes. "
5.	Sclerosing Solutions (Sclerosing Agents)IBA 04/01/2023 - "Evaluation of Topical Sclerosant Agents for Minimization of Postmastectomy Seroma: A Placebo-Controlled, Double-Blind, Randomized Trial." 04/01/2023 - "Topical sclerosants are one method used to reduce seroma. " 01/01/2017 - "Data related to seroma location, sclerosant, and resolutions were extracted. " 07/01/2016 - "The use of sclerosants at the initial operation actually increased the risk of seroma. " 07/01/2001 - "Treatment options for postoperative seromas include observation for spontaneous resolution, percutaneous aspiration, closed suction drainage, abdominal binders, and sclerosant. "
6.	Tranexamic Acid (AMCA)FDA Link 06/01/1994 - "The frequency of postoperative seroma formation was also decreased by tranexamic acid administration (27 versus 37 per cent, P = 0.2). " 12/01/2022 - "Therefore, this study aimed to determine whether the topical application of tranexamic acid would be useful to reduce seromas in a rat mastectomy model. " 12/01/2022 - "Effect of Topical Tranexamic Acid on Seroma Formation in a Rat Mastectomy Model." 08/01/2023 - "The role of tranexamic acid in reducing post-operative bleeding and seroma formation in breast surgery: A meta-analysis." 12/14/2022 - "Thoughts on: Efficacy of Tranexamic Acid in Reducing Seroma and Hematoma Formation Following Reduction Mammaplasty."
7.	Anti-Bacterial Agents (Antibiotics)IBA 03/07/2023 - "Most patients were healthy, middle-aged women categorized as ASA class I. The incidence of adverse events was 5.7%, and most commonly included antibiotic requirement (1.4%), dehiscence (1.3%), or seroma requiring drainage (1.1%). " 01/01/2023 - "At 30 days, patients with seromas were more likely to be readmitted (27 (12%) vs 28 (4%), respectively; P < 0.001), receive postoperative antibiotics (25 (12%) vs 18 (3%), respectively; P < 0.001), and undergo procedural interventions (41 (19%) vs 23 (4%), respectively; P < 0.001) than patients without seromas. " 02/01/2022 - "CT showed features suggestive of a seroma measuring 6.7 x 9.4 x 11 cm. Antibiotics were given empirically. " 01/01/2020 - "A single symptomatic seroma was treated with antibiotics and did not require mesh removal. " 02/01/2019 - "The seroma was drained and the patient treated with oral antibiotics. "
8.	ThrombinFDA Link 01/01/1997 - "Although thrombin by itself appears to have no effect on subsequent seroma development following axillary dissection, the identification of predictive variables will be helpful in designing future trials aimed at reducing the incidence of this common complication of breast surgery." 11/01/2003 - "The standard thrombin concentration (500 IU/mL) results in a rapid onset of adherence within 15 seconds that may prevent the surgeon from massaging the glue evenly throughout the pocket and may produce a premature seal on opposing surfaces, leading to a seroma cavity. " 01/01/1997 - "Eighteen of the 49 patients (37%) in the thrombin group developed a seroma in comparison to 21 of the 52 control patients (40%) (P = 0.71). " 01/01/1997 - "A prospective, randomized study was undertaken to evaluate the effect of bovine spray thrombin on seroma formation following either modified radical mastectomy (MRM) or lumpectomy with axillary dissection (LAD). " 01/01/1997 - "Seroma formation following axillary dissection for breast cancer: risk factors and lack of influence of bovine thrombin."
9.	Tissue Adhesives (Tissue Adhesive)IBA 12/01/2017 - "More importantly, successful animal experimentations in seroma prevention and instant hemostasis ultimately validated BCD tissue glue's preclinical efficacy as a tissue adhesive for various internal medical applications." 01/01/2021 - "Although various tissue adhesives and substances have been used in an effort to treat seroma formation, no therapies have been established clinically. " 01/01/2021 - "The present evaluation shows no advantage of the tissue adhesive TissuGlu® in terms of seroma formation and frequency of intervention compared to a standard drainage for mastectomies, but the shorter inpatient stay certainly has a positive effect on the quality of life." 01/01/2017 - "A mussel-inspired double-crosslinked tissue adhesive on rat mastectomy model: seroma prevention and in vivo biocompatibility." 01/01/2017 - "Subgroup analysis showed that preservation of Scarpa's fascia, tissue adhesives and, possibly, progressive tension sutures reduce, independently, seroma formation. "
10.	Hemostatics (Antihemorrhagics)IBA 11/10/2023 - "The aim of this study was to investigate the association between hemostatic agent usage and seroma development following ABCS. " 09/25/2022 - "Surgical Management of Perigraft Seroma by Graft Wrapping with Local Hemostatic Agents: A Case Report." 08/01/2018 - "No difference in the risk for seroma formation was found between the conventional and hemostatic gel groups (95% CI: 0.26, 3.95). " 09/01/2016 - "A significant direct relationship (P = 0.002) was only noted between use of the hemostatic and sealing agent and nonoccurrence of seroma. " 09/01/2016 - "Prospective randomized controlled study to assess the value of a hemostatic and sealing agent for preventing seroma after axillary lymphadenectomy."

Therapies and Procedures

1.	Sutures (Suture) 07/08/2023 - "Running quilting using barbed suture is highly effective in preventing late and refractory donor-site seromas. " 01/01/2018 - "Compared to the conventional technique, the use of tacking sutures was associated with a statistically significant reduction in the incidence of seroma from 90.9% to 51.2% (P = 0.002). " 01/01/2012 - "The positioning of sutures transcutaneous is simple and effective, the reduced incidence of seromas and the greater stability of the wall suggest to adopt this procedure fully.The" 05/01/2020 - "This study shows the efficacy of quilting suture in reducing postoperative seroma formation in BR using LDF. " 04/01/2017 - "The purpose of this study was to compare the efficacy of different products and quilting sutures at seroma prevention. "
2.	Mammaplasty (Breast Reconstruction) 09/01/2023 - "Initial experience in a small cohort undergoing prepectoral breast reconstruction showed a clinical and statistically significant reduction in seroma and any complication versus standard drains. " 01/01/2022 - "Interi effectively removed excess fluid from internal tissue compartments in prepectoral breast reconstruction and may offer significant improvement over current standards of care for seroma prevention in this procedure." 01/01/2010 - "Management of chronic seroma following latissimus dorsi breast reconstruction: a new technique." 05/01/2020 - "These results may be helpful for other future studies regarding late seroma after breast reconstruction with LDMCF." 03/01/2015 - "Management of chronic irradiated postmastectomy seromas with the microvascular breast reconstruction."
3.	Mastectomy (Mammectomy) 01/01/2018 - "This review aims to elucidate which surgical techniques are most effective in reducing the dead space and therefore seroma formation in patients undergoing mastectomy. " 08/01/2021 - "Given the potential of flap fixation in reducing seroma formation, we performed a meta-analysis of the literature to investigate the role of this approach as definitive gold standard in mastectomy surgery. " 01/01/2023 - "Previous studies have identified the added value of flap fixation in reducing seroma formation and its sequelae after mastectomy. " 10/28/2022 - "This retrospectively designed study was conducted with 27 patients who were referred to our center between 2018 and 2021 due to refractory seroma after mastectomy. " 08/01/2022 - "This study aimed to evaluate the effects of advanced bipolar energy devices on the reduction in seroma formation during mastectomy, axillary staging, and/or reconstruction. "
4.	Abdominoplasty 10/13/2023 - "PTS are highly effective in preventing seroma and can be safely employed as an alternative to drains in abdominoplasty. " 07/01/2021 - "Surgical Management of Chronic Encapsulated Abdominal Wall Seroma 8 Years after Abdominoplasty." 01/01/2021 - "The purpose of this review and meta-analysis was to assess the efficacy of PTS without drains in reducing seroma rates associated with abdominoplasty. " 10/13/2023 - "The primary aim of this study was to describe the incidence of postabdominoplasty seroma in the setting of drainless abdominoplasty with PTS. A retrospective chart review was performed of all abdominoplasties (n = 454) during a 20-year period. " 01/01/2023 - "Most published studies on abdominoplasty focus on methods to reduce the risk of seromas. "
5.	Length of Stay 09/29/2023 - "The use of PNPWT was associated with a lower incidence of superficial SSI and seroma but without significant reduction in hospital stay." 08/23/2023 - "In the pooled analysis, the TS group was associated with a lower incidence of seroma (OR = 1.71; 95% CI [1.22, 2.39], p = 0.002) and shorter hospital stay (MD = -0.07; 95% CI [-0.12, -0.02], p = 0.008). " 06/26/2023 - "It also reduces hospital stay and seroma incidence. " 05/01/2023 - "Their cumulative abdominal drain outputs, times to drain removal, hospital stay, and number and volume of seroma aspirations were compared. " 04/06/2023 - "Furthermore, it took a shorter duration for seroma to resolve in the intervention group (4 days versus 9 days; p < 0.001) with a smaller duration of hospital stay (4 days versus 9 days; p < 0.001). "