Seroma

Tumor-like sterile accumulation of serum in a tissue, organ, or cavity. It results from a tissue insult and is the product of tissue inflammation. It most commonly occurs following MASTECTOMY.

Also Known As:

Networked: 1055 relevant articles (54 outcomes, 118 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Seroma
2.	Infection
3.	Hernia (Hernias)
4.	Breast Neoplasms (Breast Cancer)
5.	Wounds and Injuries (Trauma)

Experts

1.	Rubin, J Peter: 7 articles (03/2013 - 10/2004)
2.	Mun, Goo-Hyun: 5 articles (06/2015 - 08/2012)
3.	Shermak, Michele A: 5 articles (03/2015 - 04/2006)
4.	Disa, Joseph J: 5 articles (05/2013 - 06/2007)
5.	Mehrara, Babak J: 5 articles (05/2013 - 06/2007)
6.	Bang, Sa-Ik: 4 articles (05/2015 - 08/2012)
7.	Pyon, Jai-Kyong: 4 articles (05/2015 - 08/2012)
8.	Chang, David: 4 articles (03/2015 - 04/2002)
9.	Wang, Wei: 4 articles (01/2015 - 04/2012)
10.	Goyal, Sharad: 4 articles (01/2015 - 11/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Seroma:

1.	Fibrin Tissue Adhesive (Fibrin Sealant)IBA 03/01/2006 - "The success rate for seroma resolution (100 percent) was significantly greater with fibrin sealant injection in study patients than with serial aspiration alone (23 percent) in control patients (p = 0.0077). " 10/01/1988 - "At necropsy on day 5, a significant reduction in the frequency of seroma was noted in the fibrin glue group. " 12/01/2011 - "Combined quilting and fibrin glue was also effective in reducing the average volume of the seroma and total drained volume of the seroma. " 03/01/2006 - "Percutaneous instillation of fibrin sealant may be an effective treatment for refractory donor-site seromas. " 03/01/2006 - "It was hypothesized that percutaneous instillation of fibrin sealant is effective for the postoperative treatment of refractory donor-site seromas. "
2.	ThrombinFDA Link 01/01/1997 - "Although thrombin by itself appears to have no effect on subsequent seroma development following axillary dissection, the identification of predictive variables will be helpful in designing future trials aimed at reducing the incidence of this common complication of breast surgery." 11/01/2003 - "The standard thrombin concentration (500 IU/mL) results in a rapid onset of adherence within 15 seconds that may prevent the surgeon from massaging the glue evenly throughout the pocket and may produce a premature seal on opposing surfaces, leading to a seroma cavity. " 01/01/1997 - "Eighteen of the 49 patients (37%) in the thrombin group developed a seroma in comparison to 21 of the 52 control patients (40%) (P = 0.71). " 01/01/1997 - "A prospective, randomized study was undertaken to evaluate the effect of bovine spray thrombin on seroma formation following either modified radical mastectomy (MRM) or lumpectomy with axillary dissection (LAD). " 01/01/1997 - "Seroma formation following axillary dissection for breast cancer: risk factors and lack of influence of bovine thrombin."
3.	FibrinIBA 01/01/2013 - "Noninvasive measures such as fibrin-based adhesives have thus far not been able to prevent seroma occurrence effectively. " 10/01/2012 - "Fibrin sealants may reduce seroma volumes at the donor site. " 08/01/2010 - " was a trend toward decreased operative times for fibrin sealing compared with mechanical stapling; however, the results for seroma formation remained contradictory. " 08/01/2006 - "One patient in the conventional fibrin group developed a seroma. " 01/01/2004 - "However, the seromas were easier to treat if fibrin clue was used. "
4.	TalcFDA Link 03/01/2012 - "Aerosolized talc is an effective and safe pretreatment to prevent seromas and hasten drain removal after axillary dissection." 04/01/1993 - "Based on the results of this study we conclude that talc poudrage can be safely used to minimize seroma formation after dissection of musculocutaneous flaps." 04/01/1993 - "In this study we investigated whether talc poudrage could prevent the formation of seroma following dissection of the latissimus dorsi muscle in a canine model. " 03/01/2012 - "Two seromas (33%) were noted in the NOTALC dissections vs 0 in the TALC group (0%). " 03/01/2012 - "We hypothesized that talc would decrease drain duration and prevent seromas after axillary dissection without local or systemic side effects. "
5.	tetraethylpyrazine (TEP)IBA 11/01/2005 - "This randomized prospective clinical trial demonstrated a significant reduction of analgesic consumption by using FS for mesh fixation during bilateral TEP, but it was associated with an increased incidence of postoperative seroma." 06/01/2009 - "To study the effect of closed suction drain in preperitoneal space on seroma formation after laparoscopic total extraperitoneal repair (TEP). " 11/01/2003 - "The objectives of the present study were to evaluate the incidence and treatment of seroma after TEP. " 02/01/2013 - "The complication rate for TEP, especially seroma, was considerably lower. " 11/01/2003 - "Although seroma is a frequent minor morbidity after TEP, it has no impact on postoperative recovery. "
6.	Anti-Bacterial Agents (Antibiotics)IBA 03/01/2013 - "One breast out of 11 reconstructions developed an infected seroma 8 months post-operatively, requiring aspiration and intravenous antibiotics. " 09/15/2001 - "There was no significant difference in the development of haematomas or seromas after surgery but the non-warmed group were prescribed significantly more postoperative antibiotics (p=0.002). " 02/01/2001 - "While the five aseptic seromas resolved with rest, four infected cases required explantations after one to nineteen months in spite of antibiotic therapy and the fifth one persisted without impairment under long-term antibiotics. " 11/01/2005 - "The administration of 7 days of postoperative prophylactic antibiotics appears to be a safe and effective means to limit seroma-related cellulitis." 05/01/2014 - "Year of publication, study design, inclusion and exclusion criteria, number of patients, follow-up duration, use of preoperative antibiotics, size of hernias repaired, age, body mass index (calculated as weight in kilograms divided by height in meters squared), American Society of Anesthesiologists grade, repair techniques, incidence of hernia recurrence, seroma, and SSI. "
7.	Polytetrafluoroethylene (Teflon)FDA Link 12/01/2011 - "The incidence of early complications were poor in relation to both types of implants, only seroma cases e-PTFE treated showed a prevalence of complication, in agreement with literature. " 07/01/2003 - "Percutaneous image-guided drainage of mediastinal seroma secondary to PTFE-BT shunt is a safe, minimally invasive, and effective treatment. " 12/01/1995 - "One seroma formation was found in an E-PTFE case. " 06/01/2003 - "Effective treatment for recurrent perigraft seromas of upper arm polytetrafluoroethylene grafts: report of two cases." 08/01/1998 - "The purpose of this study was to determine the risk factors associated with the occurrence of perigraft seromas complicating systemic-to-pulmonary polytetrafluoroethylene grafts. "
8.	AllodermIBA 05/01/2013 - "Seroma was the most prevalent complication; the seroma rate for AlloDerm (15.7 percent) was significantly greater than that for SurgiMend (8.3 percent). " 06/01/2012 - "Total complications were significantly higher with AlloDerm (21.4 percent versus 6.3 percent; p = 0.0003) and were driven by a significantly higher seroma rate (12.7 percent versus 1.4 percent; p = 0.0003). " 03/01/2014 - "RTU AlloDerm was associated with higher rates of seroma and cellulitis compared with FD AlloDerm (22.0% vs 18.8%, P = 0.599 and 21.0% vs 12.5%, P = 0.129, respectively). " 05/01/2008 - "Minor complications occurred in 13.1% of AlloDerm cases (cellulitis [n = 3], seroma [n = 3], hematoma [n = 1]. " 04/01/2012 - "Meta-analyses showed a significant 85% relative risk reduction in objective incidence (RR=0.15, 95% CI 0.08-0.30; P<0.00001) and 68% in subjective incidence (RR=0.32, 95% CI 0.19-0.57; P<0.00001) of Frey syndrome with AlloDerm implants; there was a significant 91% relative risk reduction in salivary fistula (RR=0.09, 95% CI 0.01-0.66; P=0.02); there was no statistical significance for the incidence of facial nerve paralysis (RR=0.96, 95% CI 0.84-1.09; P=0.51); there was no statistical significance for the incidence of seroma/sialocele (RR=1.36, 95% CI 0.66-2.80; P=0.40); there was a trend for a small effect in improving facial contour. "
9.	Biocompatible Materials (Biomaterials)IBA 06/01/2009 - "We hypothesized that the different biomaterials used to construct commonly used prosthetic mesh may influence permeability to fluid and affect seroma formation rates. " 12/01/2008 - "Postsurgical tissue adhesion and seroma formation are two serious surgical complications that have received more attention recently from the biomaterials community. " 12/01/2008 - "Materials in surgery: a review of biomaterials in postsurgical tissue adhesion and seroma prevention." 09/01/2001 - "However, the use of such biomaterials can result in the occurrence of undesirable complications such as increased risk of infection, seromas, restriction of the abdominal wall and failure caused by mesh shrinkage. " 01/01/1994 - "This article focuses special attention on the porosity, cellular permeability and molecular permeability of biomaterials and their effect on infection, host tissue incorporation and seroma formation when mesh is used for the repair of abdominal wall hernias. "
10.	Heparin (Liquaemin)FDA LinkGeneric 08/01/1998 - "Multivariable analysis defined heparin as the only significant factor associated with symptomatic perigraft seroma. " 08/01/1998 - "Heparin as a risk factor for perigraft seroma complicating the modified Blalock-Taussig shunt." 01/12/1985 - "The incidence of seroma also correlated significantly with the patient's age, the size of the breast removed, the presence of arterial hypertension and the post-operative use of heparin. " 07/01/1996 - "Avoidance of heparin after an MBTS procedure is a safe practice and may reduce bleeding problems and the incidence of significant seromas surrounding the graft. " 08/01/1998 - "Univariate analysis revealed age (p = 0.02), a diagnosis of pulmonary atresia with ventricular septal defect and systemic-pulmonary collaterals (p = 0.001), reimplantation of collaterals during the procedure (p < 0.001), and intravenous heparin administered after operation (p < 0.0001) as risk factors for symptomatic perigraft seroma. "

Therapies and Procedures

1.	Sutures (Suture) 01/01/2012 - "The positioning of sutures transcutaneous is simple and effective, the reduced incidence of seromas and the greater stability of the wall suggest to adopt this procedure fully.The" 09/01/2013 - "The aim of this study was to compare the efficacy of external compression dressing, suture flap fixation, and the conventional method of closed suction drains in the prevention of seroma formation. " 03/01/2007 - "The purpose of this study was to verify the efficacy of the use of quilting suture to prevent seroma. " 08/01/2001 - "Refinements that improved the technique substantially included incision lines exclusively in the bra line, improved flap volume resulting from the harvest of an extended fat pad, and quilting sutures to reduce the formation of seroma. " 02/01/1990 - "There has been one flap loss due to arterial disruption on day 3. An early problem was seroma formation in the donor site, which has been improved in the later patients by closing the dead space with sutures. "
2.	Transplants (Transplant) 05/01/1992 - "In the event of unsuccessful observation of a localized perigraft seroma or of unsuccessful chest drainage of a massive pleural serous effusion, graft replacement and placement of a different graft material are found to have the best results." 01/01/2004 - "Further, the Slider Graft virtually eliminated the complication of graft sweating and seroma development (p = 0.0005). " 06/01/2003 - "This method converted the brachial artery to axillary vein dialysis graft into an upper arm axillary artery to axillary vein loop bridge graft and eliminated the seroma. " 08/01/1987 - "The decrease of inhibition below detectable levels after graft removal or spontaneous resolution of the perigraft seroma suggests that the graft may induce host production of the inhibitor. " 08/01/1987 - "Furthermore, sera collected 1, 2, and 3 months after graft removal from one patient and serum collected 3 months after spontaneous resolution of a perigraft seroma from another patient failed to inhibit fibroblasts. "
3.	Mastectomy (Mammectomy) 01/01/2012 - "This study aimed to describe the vascular and cellular histopathological changes that occurred in post-mastectomy seroma in an animal model. " 01/01/2012 - "Vascular and cellular events in post-mastectomy seroma: an immunohistochemical study." 11/01/2007 - "Many previous studies had tried to reduce seroma formation after mastectomy by multimodalities. " 05/01/2001 - "The aim of this study is to evaluate the effects of Corynebacterium parvum (CP) as a sclerosing agent in both prevention and treatment of seromas after mastectomy and axillary dissection in an animal model. " 10/01/1996 - "In this study, the use of an experimental, light-activated FS under development by CryoLife (CFS) was evaluated in a rat mastectomy model in order to reduce seroma formation. "
4.	Mammaplasty (Breast Reconstruction) 01/01/2010 - "Management of chronic seroma following latissimus dorsi breast reconstruction: a new technique." 03/01/2015 - "Management of chronic irradiated postmastectomy seromas with the microvascular breast reconstruction." 05/01/2012 - "We performed a single surgeon, patient-controlled, blinded study on bilateral latissimus dorsi breast reconstruction patients in which we applied autologous platelet-leukocyte-enriched plasma to one side and measured drain amounts, time to drain removal, and seroma rate. " 12/01/2011 - "All published studies comparing the effectiveness of quilting versus no-quilting of LD flap donor site in the prevention of seroma and related morbidities in patients undergoing breast reconstruction were analysed systemically. " 12/01/2006 - "To study the ultrasonic energy dissection technique in breast reconstruction with the autologous latissimus dorsi flap and to evaluate its effect on seroma formation and other postoperative complications. "
5.	Suction (Suction Drainage) 01/01/2005 - "There was no significant difference in the incidence of seroma formation in the two groups and there was a significant reduction in the total hospital stay in patients with half vacuum suction drainage systems as compared to the full suction drainage group (p < 0.001) without any added morbidity. " 07/01/2001 - "Treatment options for postoperative seromas include observation for spontaneous resolution, percutaneous aspiration, closed suction drainage, abdominal binders, and sclerosant. " 09/01/2013 - "Closed suction drainage for several days is the standard procedure to reduce seroma formation. " 09/01/2009 - "Subcutaneous seroma due to the leakage of joint fluid in two patients was managed by additional surgery and suction drainage, and resulted in a satisfactory outcome. " 12/01/2006 - "Low-pressure suction drainage reduces seroma volume and duration of drainage leading to earlier drain removal. "