Protease La (Endopeptidase La)

A prokaryotic ATP-dependent protease that plays a role in the degradation of many abnormal proteins. It is a tetramer of 87-kDa subunits, each of which contains a proteolytic site and a ATP-binding site.

Also Known As:

Networked: 66 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gibellini, Lara: 6 articles (01/2018 - 03/2010)
2.	Cossarizza, Andrea: 5 articles (01/2018 - 03/2010)
3.	Pinti, Marcello: 5 articles (01/2018 - 03/2010)
4.	Nasi, Milena: 4 articles (01/2018 - 03/2010)
5.	Lu, Bin: 4 articles (07/2017 - 04/2012)
6.	Suzuki, Carolyn K: 4 articles (07/2017 - 05/2010)
7.	Davies, Kelvin J A: 3 articles (01/2019 - 04/2009)
8.	Carnevale, Gianluca: 3 articles (01/2018 - 12/2014)
9.	De Biasi, Sara: 3 articles (01/2018 - 12/2014)
10.	Gerdes, Kenn: 3 articles (02/2009 - 09/2003)

Related Diseases

1.	Infections 11/01/2020 - "In the present study, we characterized the involvement of Lon protease in bacterial virulence and intracellular survival in Salmonella under abiotic stress conditions resembling the conditions of a natural infection. " 04/01/2004 - "Lon protease activity causes down-regulation of Salmonella pathogenicity island 1 invasion gene expression after infection of epithelial cells." 06/01/2023 - "Finally, additional factors including lipooligosaccharide and Lon protease act independently of capsule modulation to interfere with Loki infection. " 02/01/2003 - "Taken together, the impaired ability of the lon disruption mutant to survive and grow in macrophages could be due to the enhanced susceptibility to the oxygen-dependent killing mechanism associated with respiratory burst and the low phagosomal pH. These results suggest that the Lon protease is essentially involved in the systemic infection of mice with S. " 01/01/2003 - "We evaluated the efficacy of mutants with a deletion of the stress response protease gene as candidates for live oral vaccine strains against Salmonella infection through infection studies with mice by using a Salmonella enterica serovar Typhimurium mutant with a disruption of the ClpXP or Lon protease. "
2.	Salmonella Infections (Salmonellosis) 01/01/2022 - "Coordinated interaction between Lon protease and catalase-peroxidase regulates virulence and oxidative stress management during Salmonellosis." 01/01/2003 - "We evaluated the efficacy of mutants with a deletion of the stress response protease gene as candidates for live oral vaccine strains against Salmonella infection through infection studies with mice by using a Salmonella enterica serovar Typhimurium mutant with a disruption of the ClpXP or Lon protease. "
3.	Neoplasms (Cancer) 01/01/2021 - "These results suggest that bacteria have evolved strategies to control c-MYC tissue levels in the host and that the Lon protease shows promise for therapeutic targeting of c-MYC in cancer." 01/01/2022 - "When Lon protease expression changes, glycolysis replaces respiratory metabolism in the cell, which is a common occurrence in cancer cells. " 01/01/2017 - "Mitochondrial Lon Protease and Cancer." 12/01/2015 - "Mitochondrial Lon protease at the crossroads of oxidative stress, ageing and cancer." 12/01/2010 - "Thus, we suggest that cancer cytotoxicity of the compounds is partly due to the inhibitory effects on Lon protease. "
4.	Starvation 02/01/2009 - "Nutrient starvation induced strong hicAB transcription that depended on Lon protease. " 01/01/2016 - "Here, we report that under biofilm conditions, the stringent response, which is induced upon starvation, (i) increases basal integrase and SOS regulon gene expression via induction of the SOS response and (ii) exerts biofilm-specific regulation of the integrase via the Lon protease. " 04/15/2009 - "We now show that the Lon protease is a stress-responsive protein that is induced by multiple stressors, including heat shock, serum starvation, and oxidative stress. " 02/01/2008 - "We conclude that the Lon protease supports survival during anaerobic carbon starvation by a mechanism which does not depend on Clp." 02/01/2008 - "Lon protease promotes survival of Escherichia coli during anaerobic glucose starvation."
5.	Mitochondrial Diseases (Mitochondrial Disease) 01/01/2021 - "In vitro experiments implicated the kidney protective effect of Lon protease 1, which inhibited mitochondrial dysfunction and podocyte apoptosis. " 10/01/2023 - "Further investigation showed that decrotonylation of Lon protease 1 (LONP1) at lysine 390 was associated with mitochondrial dysfunction in PCOS. " 12/01/2017 - "Lon protease: a novel mitochondrial matrix protein in the interconnection between drug-induced mitochondrial dysfunction and endoplasmic reticulum stress." 06/01/2011 - "Reduction in lon protease was achieved using specific siRNA-induced mitochondrial dysfunction in human liver SK-HEP-1 cells. " 01/01/2003 - "The resultant aberrant polypeptides could then overload the Lon protease, which also degrades oxidatively damaged polypeptides, and thereby contribute to the accumulation of damaged macromolecules, mitochondrial dysfunction and senescence. "

Related Drugs and Biologics

1.	Peptide Hydrolases (Proteases)
2.	Vaccines
3.	Proteins (Proteins, Gene)
4.	Adenosine Triphosphate (ATP)
5.	Messenger RNA (mRNA)
6.	Enzymes
7.	Amino Acids
8.	Proteasome Endopeptidase Complex (Proteasome)
9.	Aconitate Hydratase (Aconitase)
10.	Dynamins (Dynamin)

Related Therapies and Procedures

1.	Therapeutics
2.	Highly Active Antiretroviral Therapy (HAART)
3.	Drug Therapy (Chemotherapy)