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Sarcoglycans (beta Sarcoglycan)

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A family of transmembrane dystrophin-associated proteins that play a role in the membrane association of the DYSTROPHIN-ASSOCIATED PROTEIN COMPLEX.

Also Known As:

beta Sarcoglycan; 43-kDa Dystrophin-Associated Glycoprotein; 50-kDa Dystrophin-Associated glycoprotein; Adhalin; Sarcoglycan Complex; Sarcoglycan Complexes; alpha-Sarcoglycan; delta-Sarcoglycan; epsilon-Sarcoglycan; gamma-Sarcoglycan; zeta-Sarcoglycan; 43 kDa Dystrophin Associated Glycoprotein; 50 kDa Dystrophin Associated glycoprotein; Complex, Sarcoglycan; Complexes, Sarcoglycan; Dystrophin-Associated Glycoprotein, 43-kDa; Dystrophin-Associated glycoprotein, 50-kDa; Glycoprotein, 43-kDa Dystrophin-Associated; alpha Sarcoglycan; delta Sarcoglycan; epsilon Sarcoglycan; gamma Sarcoglycan; glycoprotein, 50-kDa Dystrophin-Associated; zeta Sarcoglycan; beta-Sarcoglycan

Networked: 381 relevant articles (3 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	McNally, Elizabeth M: 17 articles (03/2011 - 07/2002)
2.	Heydemann, Ahlke: 8 articles (03/2011 - 02/2004)
3.	McNally, E M: 8 articles (08/2001 - 01/2000)
4.	Klein, Christine: 7 articles (08/2010 - 11/2002)
5.	Wheeler, Matthew T: 6 articles (03/2004 - 07/2002)
6.	Hack, A A: 6 articles (03/2001 - 01/2000)
7.	Betto, Romeo: 5 articles (07/2014 - 07/2004)
8.	Favaloro, Angelo: 5 articles (02/2014 - 05/2008)
9.	Cutroneo, Giuseppina: 5 articles (02/2014 - 05/2008)
10.	Nigro, Vincenzo: 5 articles (04/2013 - 11/2003)

Related Diseases

1.	Muscular Dystrophies (Muscular Dystrophy) 01/01/2011 - "The delta-sarcoglycan-deficient hamster is an excellent model to study muscular dystrophy. " 04/25/1998 - "Linkage studies have confirmed the existence of clinical an genetic heterogeneity among the muscular dystrophies due to adhalin deficiency. " 01/01/2016 - "This review discusses the role of the sarcoglycan complex in skeletal muscle and describes the functional deficiencies that lead to muscular dystrophies. " 06/01/2015 - "Muscular dystrophy was suspected and immunohistochemical staining of muscle cryosections demonstrated reduced sarcoglycans. " 01/01/2014 - "Overall, we assert that altered load-sensing mechanisms exist in muscular dystrophies where the sarcoglycans are absent."
2.	Myoclonus (Nocturnal Myoclonus) 07/01/2006 - "Myoclonus, motor deficits, alterations in emotional responses and monoamine metabolism in epsilon-sarcoglycan deficient mice." 05/01/2006 - "Individuals with myoclonus should be tested for the epsilon-sarcoglycan gene (DYT-11). " 08/15/2003 - "Myoclonus in a patient with a deletion of the epsilon-sarcoglycan locus on chromosome 7q21." 09/01/2003 - "This study suggests that epsilon-sarcoglycan does not play an important role in sporadic myoclonus-dystonia and supports genetic heterogeneity in familial cases." 06/01/2015 - "Myoclonus-dystonia related to epsilon-sarcoglycan gene mutations is characterized by myoclonic jerks and mild to moderate dystonia. "
3.	Dystonia (Limb Dystonia) 11/01/2002 - "Epsilon-sarcoglycan mutations found in combination with other dystonia gene mutations." 09/01/2003 - "This study suggests that epsilon-sarcoglycan does not play an important role in sporadic myoclonus-dystonia and supports genetic heterogeneity in familial cases." 06/01/2015 - "Myoclonus-dystonia related to epsilon-sarcoglycan gene mutations is characterized by myoclonic jerks and mild to moderate dystonia. " 06/01/2013 - "Mutations or exon deletions of the epsilon-sarcoglycan (SGCE) gene cause myoclonus-dystonia (M-D), but a subset of M-D patients are mutation-negative and the sensitivity and specificity of current genetic testing criteria are unknown. " 06/01/2013 - "Defining the epsilon-sarcoglycan (SGCE) gene phenotypic signature in myoclonus-dystonia: a reappraisal of genetic testing criteria."
4.	Sarcoglycanopathies 01/01/2009 - "Proper assembly, trafficking and targeting of the sarcoglycan complex is of vital importance, and mutations that severely perturb tetramer formation and localisation result in sarcoglycanopathy. " 07/01/2008 - "The proper assembly of the sarcoglycan complex represents a critical issue of sarcoglycanopathies, as several mutations severely perturb tetramer formation. " 01/01/2007 - "Furthermore, there are unclear data about the actual role of sarcoglycans in human skeletal muscle affected by sarcoglycanopathies. " 11/01/2004 - "Among them, gene defects in the sarcoglycan complex (sarcoglycanopathy) have been added to LGMD2C-2F. " 09/01/2002 - "Here, we report construction and use of AAV vectors expressing either alpha- or beta-sarcoglycan, the genes responsible for the most common forms of the human sarcoglycanopathies. "
5.	Spasm (Spasms) 03/01/2004 - "Intriguingly, successful restoration of the cardiomyocyte sarcoglycan complex also eliminated coronary artery vascular spasm, while restoration of smooth muscle sarcoglycan in the background of sarcoglycan-null alleles did not. " 08/01/2007 - "The 5'-UTR polymorphism on delta-sarcoglycan gene was associated with coronary spasm in Japanese patients with HCM." 08/01/2007 - "Delta-sarcoglycan plays a crucial role in the pathogenesis of HCM and coronary spasm in a mouse model. " 03/01/2004 - "Supporting this notion, vascular spasm was noted in coronary arteries, and disruption of the sarcoglycan complex was observed in vascular smooth muscle providing a molecular mechanism for spasm. " 08/01/2003 - "Recent evidence suggests that disruption of the smooth muscle sarcoglycan complex is not required for the development of vascular spasm and that vascular spasm arises from a vascular smooth muscle cell-extrinsic process."

Related Drugs and Biologics

1.	Sarcoglycans (beta Sarcoglycan)
2.	Proteins (Proteins, Gene)
3.	Dystrophin
4.	Dystroglycans (Dystroglycan)
5.	Laminin (Merosin)
6.	Integrins
7.	Myostatin
8.	Agrin
9.	Muscle Proteins (Muscle Protein)
10.	Creatine Kinase (Creatine Phosphokinase)

Related Therapies and Procedures

1.	Deep Brain Stimulation
2.	Transplantation (Transplant Recipients)
3.	Tenotomy
4.	Muscle Stretching Exercises (Stretching, Static)
5.	Therapeutics