MAP Kinase Kinase Kinase 3

A 70-kDa MAPK kinase kinase with specificity for MAP KINASE KINASE 5.

Also Known As:

ERK Kinase Kinase 3; MAP3K3 Protein Kinase; MAPK-ERK Kinase Kinase 3; MEK Kinase 3; MEKK3 Protein Kinase; Mitogen-Activated Protein Kinase Kinase Kinase 3; MAPK ERK Kinase Kinase 3; Mitogen Activated Protein Kinase Kinase Kinase 3; Protein Kinase, MAP3K3; Protein Kinase, MEKK3

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Yang, Jianhua: 2 articles (01/2014 - 10/2007)
2.	Hu, Jing: 1 article (04/2022)
3.	Liu, Yun: 1 article (04/2022)
4.	Wang, Qian: 1 article (04/2022)
5.	Wang, Weiwei: 1 article (04/2022)
6.	Mao, Yanjiao: 1 article (01/2019)
7.	Shi, Lei: 1 article (01/2019)
8.	Yin, Wei: 1 article (01/2019)
9.	Deng, Kai: 1 article (06/2015)
10.	Ding, Jingjin: 1 article (06/2015)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2014 - "This gene encodes mitogen-activated protein kinase kinase kinase 3 (MAP3K3/MEKK3), which has not yet been reported to be associated with cancer-causing genetic aberrations. " 10/01/2007 - "Mitogen-activated protein kinase kinase kinase 3 (MEKK3) plays an essential role in embryonic angiogenesis, but its role in tumor growth and angiogenesis is unknown. "
2.	Carcinogenesis 01/02/2014 - "Mitogen activated protein kinase kinase kinase 3 (MAP3K3/MEKK3) overexpression is an early event in esophageal tumorigenesis and is a predictor of poor disease prognosis."
3.	Ganglion Cysts (Ganglion) 06/15/2023 - "Mechanistic analysis found that miR-150-5p from Sca-1+ exosomes repressed the mitogen-activated protein kinase kinase kinase 3 (MEKK3)/JNK/c-Jun axis, leading to IL-6 and TNF-α downregulation, and subsequently reduced microglial polarization, all of which contributes to reduced ganglion cell apoptosis and preservation of proper retinal morphology. "
4.	Central Nervous System Cavernous Hemangioma 06/02/2015 - "Structural Insights into the Molecular Recognition between Cerebral Cavernous Malformation 2 and Mitogen-Activated Protein Kinase Kinase Kinase 3."
5.	Neoplasm Metastasis (Metastasis) 11/01/2023 - "MPTP- and MPP+-induced PD cells and animal models were treated with Nissl staining to assess neuronal damage in the substantia nigra (SN) area; immunohistochemistry to detect TH expression in the SN; TUNEL staining to detect apoptosis in the SN area; Western blotting to detect the inflammatory factors NF-κB, TNF-α, IL-6 and mitogen-activated protein kinase kinase kinase 3 (MEKK3); Griess assay for NO; RT‒qPCR for metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and miR-124 expression; Cell proliferation was assessed by CCK-8. "

Related Drugs and Biologics

1.	Interleukin-6 (Interleukin 6)
2.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
3.	Sincalide
4.	Retinaldehyde (Retinal)