MAP Kinase Kinase Kinase 2

A 70-kDa MAP kinase kinase kinase with specificity for MAP KINASE KINASE 5. It is activated during the cellular response to GROWTH FACTORS, oxidative stress, and hyperosmotic conditions.

Also Known As:

MAP3K2 Protein Kinase; MEK Kinase 2; MEKK-2 Protein Kinase; MEKK2 Protein; MEKK2 Protein Kinase; MEKK 2 Protein Kinase; Protein Kinase, MAP3K2; Protein Kinase, MEKK-2; Protein Kinase, MEKK2

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Gong, Yufang: 1 article (05/2021)
2.	Zhang, Yuling: 1 article (05/2021)
3.	Huang, Wei: 1 article (02/2010)
4.	Jiang, Xiuli: 1 article (02/2010)
5.	Johnson, Mark D: 1 article (02/2010)
6.	Kim, Hyunsoo: 1 article (02/2010)
7.	Park, Peter J: 1 article (02/2010)
8.	Pennicooke, Brenton: 1 article (02/2010)

Related Diseases

1.	Experimental Arthritis 05/01/2021 - "To study the role of Allicin in regulating Treg/Th17 ratio in splenic lymphocyte by increasing the expression of MEKK2 protein in MAPK signaling pathway, and to explore the mechanism of immune response in mice with collagen-induced arthritis (CIA). " 05/01/2021 - "Allicin regulates Treg/Th17 balance in mice with collagen-induced arthritis by increasing the expression of MEKK2 protein."
2.	Glioblastoma (Glioblastoma Multiforme) 02/02/2010 - "We demonstrate that miR-26a alone can transform cells and it promotes glioblastoma cell growth in vitro and in the mouse brain by decreasing PTEN, RB1, and MAP3K2/MEKK2 protein expression, thereby increasing AKT activation, promoting proliferation, and decreasing c-JUN N-terminal kinase-dependent apoptosis. "
3.	Rheumatoid Arthritis 05/01/2021 - "In terms of mechanism, Allicin may play a therapeutic role in rheumatoid arthritis (RA) by increasing the expression of MEKK2 protein and affecting Treg/Th17 ratio."

Related Drugs and Biologics

1.	allicin
2.	JNK Mitogen-Activated Protein Kinases