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MAP Kinase Kinase Kinase 1

A 195-kDa zinc finger motif-containing MAP kinase kinase kinase with broad specificity for MAP KINASE KINASES. It localizes to the CYTOSKELETON and can activate a variety of MAP kinase-dependent pathways.
Also Known As:
MAP ERK Kinase Kinase 1; MAP3K1 Protein; MEK Kinase 1; MEKK-1 Protein Kinase; MEKK1 Protein; MEKK1 Protein Kinase; MEKK 1 Protein Kinase; Mitogen Activated Protein Kinase Kinase Kinase 1; Protein Kinase, MEKK-1; Mitogen-Activated Protein Kinase Kinase Kinase 1
Networked: 32 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Bai, Xuefeng: 2 articles (03/2022 - 02/2016)
2. He, Miao: 2 articles (03/2022 - 02/2016)
3. Jiang, Longyang: 2 articles (03/2022 - 02/2016)
4. Wang, Yan: 2 articles (03/2022 - 02/2016)
5. Wei, Minjie: 2 articles (03/2022 - 02/2016)
6. Yu, Lifeng: 2 articles (03/2022 - 02/2016)
7. Zhao, Lin: 2 articles (03/2022 - 02/2016)
8. Xia, Ying: 2 articles (05/2011 - 08/2008)
9. Diao, Ji-Zhe: 1 article (06/2022)
10. Dong, Li-Ping: 1 article (06/2022)

Related Diseases

1. Fatty Liver
2. Breast Neoplasms (Breast Cancer)
3. Neoplasms (Cancer)
12/01/2011 - "To assess possible effects of apigenin on migration of bladder smooth muscle (SM) cell, we isolated SM cells from peri-cancer tissue of human bladder and established a cell model that was capable to overexpress transiently MEKK1 (MEK kinase 1). "
01/01/2020 - "Together, these findings provide a direct link between the MEKK1 protein and tubulin, which is likely to be relevant to cancer cell migration and response to microtubule-modulating therapies."
12/01/2008 - "Among 26 statistically reliable genes, the expression of apoptosis related genes such as ADAM22, Bax, BCL2L14, and UBD, as well as tumor suppressor-related genes like Axin2 and ATF, and also mitogen-activated protein kinase-related genes like mitogen-activated protein kinase kinase kinase 1, histamine receptor, and RAB24, were significantly changed in cells responsive to pressure-induced oxidative stress."
03/01/2004 - "This report describes several signaling pathways that are potential targets for inflammation and cancer, including those that involve the following signaling molecules: Jun N-terminal kinase, cyclin-dependent kinases, hypoxia-inducible factor, p21-activated kinases, MEK kinase 1, phosphoinositide 3-kinases, myc, p53, Smad, hedgehog, nuclear factor-kB and G protein. "
02/01/2021 - "Mutated genes of the highest frequency were tumor protein p53 (TP53, 54%), phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA, 41%), estrogen receptor 1 (ESR1, 12%), myeloid/lymphoid or mixed-lineage leukemia protein 3 (MLL3, 11%), DNA (cytosine-5)-methyltransferase 3A (DNMT3A, 10%), erb-b2 receptor tyrosine kinase 2 (ERBB2, 10%), GATA binding protein 3 (GATA3, 8%), FAT atypical cadherin 1 (FAT1, 7%), phosphatase and tensin homolog (PTEN, 6%), and mitogen-activated protein kinase kinase kinase 1 (MAP3K1, 6%). "
4. 46,XY Disorder of Sex Development (Male Pseudohermaphroditism)
5. Prostatic Neoplasms (Prostate Cancer)

Related Drugs and Biologics

1. MicroRNAs (MicroRNA)
2. Mitogen-Activated Protein Kinases
3. Estrogen Receptor alpha
4. Member 1 Subfamily B ATP Binding Cassette Transporter
5. NF-kappa B (NF-kB)
6. Androgen Receptors (Androgen Receptor)
7. Proteins (Proteins, Gene)
8. Doxorubicin (Adriamycin)
9. p21-Activated Kinases
10. Myeloid-Lymphoid Leukemia Protein

Related Therapies and Procedures

1. Therapeutics