Mitogen-Activated Protein Kinase 11

A 38-kDa mitogen-activated protein kinase that is expressed in a broad variety of cell types. It may play a role in regulating cell proliferation and TRANSCRIPTION FACTOR AP-1 dependent transcription.

Also Known As:

MAPK11 Mitogen-Activated Protein Kinase; Mitogen-Activated Protein Kinase Eleven; SAP Kinase-2; SAPK2; SAPK2b; Stress-Activated Protein Kinase 2; Stress-Activated Protein Kinase 2b; p38(beta) MAP Kinase; p38beta MAP Kinase; Kinase, p38beta MAP; MAP Kinase, p38beta; MAPK11 Mitogen Activated Protein Kinase; Mitogen Activated Protein Kinase 11; Mitogen Activated Protein Kinase Eleven; SAP Kinase 2; Stress Activated Protein Kinase 2; Stress Activated Protein Kinase 2b

Networked: 19 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Huot, Jacques: 2 articles (01/2004 - 11/2002)
2.	Lou, Dengji: 1 article (09/2018)
3.	Wang, Houping: 1 article (09/2018)
4.	Yu, Diqiu: 1 article (09/2018)
5.	Beatty, Sean: 1 article (01/2017)
6.	Malo, Danielle: 1 article (01/2017)
7.	Rached-D'Astous, Leïla: 1 article (01/2017)
8.	Anderson, Lauren: 1 article (12/2011)
9.	Artinian, Nicholas: 1 article (12/2011)
10.	Bashir, Tariq: 1 article (12/2011)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2004 - "This interaction activates, in the cancer cells, the MAPK SAPK2/p38, which leads to their transendothelial migration (Laferrière et al., J Biol Chem 2001; 276: 33762). " 12/01/2023 - "The Cancer Genome Atlas (TCGA) database mining and pathological analysis were carried out to determine the correlation of ETV4 with tumor necrosis factor-alpha (TNF-α) and mitogen-activated protein kinase 11 (MAPK11). " 09/07/2001 - "Overall, our results suggest that the regulation of transendothelial migration of tumor cells involves two essential steps as follows: adhesion to the endothelium through adhesion molecules, such as E-selectin, and increased motogenic potential through adhesion-mediated activation of the SAPK2/p38 pathway." 02/15/2001 - "Our findings confirm the role of LMP1 in transactivation of cellular genes possibly important for tumor immunoescape but show that more than one signaling pathway is involved in this activation and suggests the necessity of a defined conformation of CTARs to activate IL-10 involving p38/SAPK2." 11/01/2002 - "We review here the roles played by the endothelial adhesive molecule E-selectin and by the motogenic stress-activated protein kinase-2 (SAPK2/p38) pathway of cancer cells in modulating transendothelial migration of cancer cells."
2.	Stroke (Strokes) 05/01/2004 - "Therefore, interleukin-1beta (IL-1beta), which contributes to stroke-induced brain injury and activates p38/SAPK2, and hyperosmolarity induced by sorbitol, a potent stimulus of p38/SAPK2 in non-neuronal cells, were used to investigate a possible involvement of p38/SAPK2 in GJC modulation in mouse cultured astrocytes. " 04/14/2000 - "Two relatively well characterised kinase signalling pathways are those involving MAPK/ERK and p38/SAPK2, that are known to be activated in vitro by various factors known to increase following stroke, such as glutamate, IL-1 and TNF. "
3.	Inflammation (Inflammations) 01/01/1999 - "In vascular endothelial cells, where the basal level of expression of Hsp27 is high, SAPK2 mediates oxidative stress- and vascular endothelial growth factor (VEGF)-induced actin reorganization and VEGF-induced cell migration, suggesting a key role for this MAP kinase pathway in inflammation and angiogenic processes." 10/01/2002 - "Those include serine protein inhibitor 2.2, maspin, mitogen- and stress-activated protein kinase 2, and macrophage colony-stimulating factor 1. Our findings demonstrate that while mast cells are essential for both antigen- and SP-induced bladder inflammation, there are common genes and unique genes expressed in each type of inflammatory reaction. "
4.	Carcinoma (Carcinomatosis) 09/07/2001 - "We investigated the roles of E-selectin and of stress-activated protein kinase-2 (SAPK2/p38) in modulating endothelial adhesion and transendothelial migration of HT-29 colon carcinoma cells. " 09/07/2001 - "Transendothelial migration of colon carcinoma cells requires expression of E-selectin by endothelial cells and activation of stress-activated protein kinase-2 (SAPK2/p38) in the tumor cells." 04/01/2001 - "We discovered that a shift between the state of tumorigenicity and dormancy in human carcinoma (HEp3) is attained through regulation of the balance between two classical mitogen-activated protein kinase (MAPK)-signaling pathways, the mitogenic extracellular regulated kinase (ERK) and the apoptotic/growth suppressive stress-activated protein kinase 2 (p38(MAPK)), and that urokinase plasminogen activator receptor (uPAR) is an important regulator of these events. "
5.	Smith-Magenis Syndrome 01/01/2011 - "Six of the seven genes were identified, CSNK1E (casein kinase 1 epsilon), DGCR8 (Di George syndrome critical region 8), GGA1 (Golgi associated gamma adaptin ear containing ARF binding protein 1), MAPK11 (mitogen activated protein kinase 11), SMCR7L (Smith-Magenis syndrome chromosome region candidate 7-like), andTBC1D22A (TBC1 domain family member 22A). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Phosphotransferases (Kinase)
3.	Mitogen-Activated Protein Kinase 11
4.	p38 Mitogen-Activated Protein Kinases
5.	E-Selectin
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7.	Interleukin-1 (Interleukin 1)
8.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
9.	Urokinase Plasminogen Activator Receptors
10.	Interleukin-1beta (Interleukin 1 beta)