Bovine Respiratory Disease Complex

A multifactorial disease of CATTLE resulting from complex interactions between environmental factors, host factors, and pathogens. The environmental factors act as stressors adversely affecting the IMMUNE SYSTEM and other host defenses and enhancing transmission of infecting agents.

Networked: 22 relevant articles (5 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pneumonic Pasteurellosis (Shipping Fever)
2.	Respiratory Tract Diseases (Respiratory Tract Disease)
3.	Paramyxoviridae Infections (Parainfluenza)

Experts

1.	Church, J S: 2 articles (04/2014 - 10/2013)
2.	Regev-Shoshani, G: 2 articles (04/2014 - 10/2013)
3.	Torres, Siddartha: 2 articles (06/2013 - 06/2013)
4.	Thomson, Dan U: 2 articles (06/2013 - 06/2013)
5.	Bello, Nora M: 2 articles (06/2013 - 06/2013)
6.	Reinhardt, Chris D: 2 articles (06/2013 - 06/2013)
7.	Nosky, Bruce J: 2 articles (06/2013 - 06/2013)
8.	Hernandez Gifford, J A: 1 article (04/2015)
9.	Gifford, C A: 1 article (04/2015)
10.	Wilson, B K: 1 article (04/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Bovine Respiratory Disease Complex:

1.	gamithromycinIBA 06/01/2013 - "Field study of the comparative efficacy of gamithromycin and tulathromycin for the treatment of undifferentiated bovine respiratory disease complex in beef feedlot calves." 06/01/2013 - "To compare the efficacy of gamithromycin with that of tulathromycin for the treatment of undifferentiated bovine respiratory disease complex (BRDC) in feedlot calves. " 06/01/2013 - "To compare the efficacy of gamithromycin with that of tulathromycin for control of undifferentiated bovine respiratory disease complex (BRDC) in feedlot calves. " 06/01/2013 - "Field study of the comparative efficacy of gamithromycin and tulathromycin for the control of undifferentiated bovine respiratory disease complex in beef feedlot calves at high risk of developing respiratory tract disease."
2.	tulathromycinIBA 06/01/2013 - "Field study of the comparative efficacy of gamithromycin and tulathromycin for the treatment of undifferentiated bovine respiratory disease complex in beef feedlot calves." 06/01/2013 - "To compare the efficacy of gamithromycin with that of tulathromycin for the treatment of undifferentiated bovine respiratory disease complex (BRDC) in feedlot calves. " 06/01/2013 - "To compare the efficacy of gamithromycin with that of tulathromycin for control of undifferentiated bovine respiratory disease complex (BRDC) in feedlot calves. " 06/01/2013 - "Field study of the comparative efficacy of gamithromycin and tulathromycin for the control of undifferentiated bovine respiratory disease complex in beef feedlot calves at high risk of developing respiratory tract disease."
3.	VaccinesIBA 12/01/2007 - "A review of the biology of bovine herpesvirus type 1 (BHV-1), its role as a cofactor in the bovine respiratory disease complex and development of improved vaccines." 02/01/1994 - "Current modified live and killed BHV-1 vaccines have not reduced the incidence of bovine herpesvirus-1 (BHV-1), the principal viral agent in bovine respiratory disease complex. " 10/01/2000 - "To determine the effect of location for administration of clostridial vaccines on behavior, growth performance, and health of calves at a feedlot, the relative risk of calves developing an injection-site reaction or being misdiagnosed as having bovine respiratory disease complex (BRDC), and the percentage of subcutaneous injection-site reactions that were detectable on carcasses after the hides were removed. " 01/01/2015 - "Systematic review and meta-analysis of the effectiveness of commercially available vaccines against bovine herpesvirus, bovine viral diarrhea virus, bovine respiratory syncytial virus, and parainfluenza type 3 virus for mitigation of bovine respiratory disease complex in cattle." 01/01/2015 - "To evaluate and analyze data from controlled studies on the effectiveness of vaccinating cattle with commercially available viral antigen vaccines for mitigation of the effects of bovine respiratory disease complex (BRDC). "
4.	Theophylline (Theon)FDA LinkGeneric 09/01/1989 - "A field trial was conducted to determine the efficacy of theophylline in relieving respiratory distress associated with bovine respiratory disease complex (shipping fever). "
5.	AntigensIBA 01/01/2015 - "To evaluate and analyze data from controlled studies on the effectiveness of vaccinating cattle with commercially available viral antigen vaccines for mitigation of the effects of bovine respiratory disease complex (BRDC). " 04/01/1989 - "Antibodies to Pasteurella haemolytica somatic antigens in two models of the bovine respiratory disease complex."
6.	Nitric Oxide (Nitrogen Monoxide)FDA Link 04/01/2014 - "Safety, bioavailability and mechanism of action of nitric oxide to control Bovine Respiratory Disease Complex in calves entering a feedlot." 10/01/2013 - "Prophylactic nitric oxide treatment reduces incidence of bovine respiratory disease complex in beef cattle arriving at a feedlot."
7.	Anti-Bacterial Agents (Antibiotics)IBA 11/01/1974 - "Prophylactic use of antibiotics in preventing bovine respiratory disease complex." 01/01/2015 - "Bovine respiratory disease complex (BRDC) is an important cause of mortality and morbidity in cattle; costing the dairy and beef industries millions of dollars annually, despite the use of vaccines and antibiotics. "
8.	tilmicosinIBA 01/01/2002 - "Tilmicosin is a potent antimicrobial with broad-spectrum activity against the bacterial agents involved in the bovine respiratory disease complex. " 04/01/1993 - "MICOTIL 300 is a new macrolide antibiotic for the treatment of Bovine Respiratory Disease complex. "
9.	ethyleneIBA 08/01/1972 - "The role of EDDI (ethylene diamine dihydriodide) in bovine respiratory disease complex: another point of view." 05/01/1972 - "What role for EDDI (ethylene diamine dihydriodide) in bovine respiratory disease complex?"
10.	Lactic AcidFDA LinkGeneric 11/01/2004 - "The methods were used to determine whether, and at which values, blood lactate in Belgian White and Blue or maximum tidal volumes in Holstein calves should be measured before deciding to treat or not a calf suffering from the bovine respiratory disease complex. "

Therapies and Procedures

1.	Resuscitation 04/01/1998 - "Infusion of HSS may be beneficial for initial resuscitation of cattle with naturally developing bovine respiratory disease complex."
2.	Subcutaneous Injections 10/01/2000 - "To determine the effect of location for administration of clostridial vaccines on behavior, growth performance, and health of calves at a feedlot, the relative risk of calves developing an injection-site reaction or being misdiagnosed as having bovine respiratory disease complex (BRDC), and the percentage of subcutaneous injection-site reactions that were detectable on carcasses after the hides were removed. "