Tumor Necrosis Factors

A family of proteins that were originally identified by their ability to cause NECROSIS of NEOPLASMS. Their necrotic effect on cells is mediated through TUMOR NECROSIS FACTOR RECEPTORS which induce APOPTOSIS.

Also Known As:

Networked: 94 relevant articles (2 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rahimi, Roja: 2 articles (07/2007 - 01/2007)
2.	Abdollahi, Mohammad: 2 articles (07/2007 - 01/2007)
3.	Nikfar, Shekoufeh: 2 articles (07/2007 - 01/2007)
4.	Hansel, Gisele: 1 article (12/2015)
5.	Guella, Felipe Lhywinskh: 1 article (12/2015)
6.	Tonon, André Comiran: 1 article (12/2015)
7.	Oses, Jean Pierre: 1 article (12/2015)
8.	Pettenuzzo, Letícia Ferreira: 1 article (12/2015)
9.	Duarte, Thiago: 1 article (12/2015)
10.	Achaval, Matilde: 1 article (12/2015)

Related Diseases

1.	Crohn Disease (Crohn's Disease) 01/01/2007 - "To determine whether anti-tumor necrosis factors induce clinical response and remission in patients with Crohn's disease, PUBMED, OVID, and SCOPUS databases were searched for studies investigated the efficacy of anti-tumor necrosis factors on CD. " 01/01/2007 - "It seems that anti-tumor necrosis factors are not effective for induction of response and remission in patients with Crohn's disease." 01/01/2007 - "Do anti-tumor necrosis factors induce response and remission in patients with acute refractory Crohn's disease? " 03/01/2013 - "The sample comprised 100 patients (mean age, 42 years; 68% Crohn's disease; 49% on thiopurines; and 14% on anti-tumor necrosis factors during follow-up). " 09/01/2009 - "Therefore, the anti Tumor necrosis factors have been used for treating many inflammatory pathologies such as rheumatoid arthritis or Crohn's disease with success. "
2.	Leukopenia 07/01/2015 - "The consensus statements comprised four parts: (1) pre-treatment evaluation and management strategy, including value of thiopurine S-methyltransferase screening, dosing schedule, and novel biomarkers for predicting thiopurine-induced leukopenia; (2) treatment with thiopurines with regards to optimal duration of thiopurine treatment and long-term outcomes of combination therapy with anti-tumor necrosis factors; (3) safety of thiopurines, especially during pregnancy and lactation; and (4) monitoring side effects or efficacy of therapy using biomarkers. "
3.	Neoplasms (Cancer) 03/01/2013 - "Natural killer (NK) cells and dendritic cells (DCs) mediate tumor cell apoptosis using tumor necrosis factor superfamily ligands (TNFSFLs). " 07/01/2012 - "DAB2IP is a critical component of many signal transduction pathways mediated by Ras and tumor necrosis factors including apoptosis pathways, and it is involved in the formation of many types of tumors. " 03/01/2008 - "TRAIL (Apo2L), a cytokine from the family of tumor necrosis factors (TNF), causes apoptosis in various types of tumor cells but is not toxic for normal cells. " 02/01/1993 - "Induction of chromosomal rearrangement by tumor necrosis factors produced by primary B lymphoblastoid cells derived from cancer patients." 10/01/1992 - "Heat treatment and various other stresses render tumor cells resistant to cytotoxicity mediated by tumor necrosis factors (TNFs). "
4.	Stomach Neoplasms (Stomach Cancer) 01/01/2004 - "Gastric cancer cells of SGC-7901, MKN28, MKN45 and AGS lines were cultured in PRMI-1640 medium and the apoptosis rates of the cells of 4 lines were observed after treatment of tumor necrosis factors related apoptosis inducing ligand (TRAIL) with a flow cytometer. " 01/01/2004 - "To study the effect of NF-kappaB, survivin, Bcl-2 and Caspase3 on tumor necrosis factors related apoptosis inducing ligand (TRAIL) induced apoptosis of gastric cancer cells. "
5.	Ankylosing Spondylitis 05/01/2013 - "There are new classification criteria of axial and peripheral SpA as well as the CASPAR criteria for PsA, a new composite measure for ankylosing spondylitis and axial SpA, the ASDAS, new measures for the heterogeneous clinical domains of PsA, studies of biologic treatments of axial and peripheral SpA, and new drugs beyond anti-tumor necrosis factors for PsA and SpA. "

Related Drugs and Biologics

1.	Biological Markers (Surrogate Marker)
2.	thiopurine methyltransferase (thiopurine S-methyltransferase)
3.	Interferons
4.	NF-kappa B (NF-kB)
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Cytokines
7.	Interleukins
8.	Interferon-gamma (Interferon, gamma)
9.	Interleukin-1 (Interleukin 1)
10.	Interleukin-6 (Interleukin 6)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Hematopoietic Stem Cell Transplantation
3.	Plasmapheresis
4.	Aftercare (After-Treatment)