Mitogen-Activated Protein Kinase 6

A 97-kDa extracellular signal-regulated MAP kinase. Mitogen-activated protein kinase 6 levels increase during cellular differentiation, while in proliferating cells the enzyme is degraded rapidly via the PROTEASOME ENDOPEPTIDASE COMPLEX.

Also Known As:

ERK3 Kinase; MAPK6 Mitogen-Activated Protein Kinase; p97(MAPK) Protein; p97MAPK Protein; Extracellular Signal Regulated Kinase 3; Kinase, ERK3; MAPK6 Mitogen Activated Protein Kinase; Mitogen Activated Protein Kinase 6; Extracellular Signal-Regulated Kinase 3

Networked: 16 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Long, Weiwen: 5 articles (02/2021 - 01/2017)
2.	Elkhadragy, Lobna: 3 articles (06/2020 - 01/2017)
3.	Alsaran, Hadel: 2 articles (06/2020 - 10/2018)
4.	Chen, Minyi: 2 articles (01/2019 - 01/2017)
5.	An, Hyun-Jung: 1 article (01/2022)
6.	Chen, Suwen: 1 article (01/2022)
7.	Chen, Weidong: 1 article (01/2022)
8.	Cho, Eun Suh: 1 article (01/2022)
9.	Cho, Yong-Yeon: 1 article (01/2022)
10.	Choi, Jin-Sung: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 06/05/2020 - "Taken together, the findings of this study advance our understanding of the molecular regulation of ERK3 signaling by unraveling the role of the C-terminus tail in regulating ERK3 kinase activity and functions in cancer cells. " 06/05/2020 - "In this study, we investigated the role of the elongated C-terminus extension in regulating ERK3 kinase activity and its ability to promote cancer cell migration and invasion. " 01/01/2022 - "EGLN3 catalyzes the hydroxylation of extracellular signal-regulated kinase 3 (Erk3), a potent driver of cancers. " 01/01/2021 - "Our results demonstrate an obligatory role for ERK3 in NSCLC tumor progression and suggest that ERK3 kinase inhibitors can be pursued for treating KRAS G12C-driven tumors." 06/05/2020 - "The C-Terminus Tail Regulates ERK3 Kinase Activity and Its Ability in Promoting Cancer Cell Migration and Invasion."
2.	Lung Neoplasms (Lung Cancer) 10/19/2018 - "Taken together, our study unravels the importance of Ser189 phosphorylation for intramolecular regulation of ERK3 kinase activity and invasiveness-promoting ability in lung cancer cells." 01/01/2023 - "Extracellular signal-regulated kinase 3 (ERK3) promotes cell migration and tumor metastasis in multiple cancer types, including lung cancer. " 02/12/2021 - "Extracellular signal-regulated kinase 3 (ERK3) is an atypical mitogen-activated protein kinase (MAPK) whose biochemical features and cellular regulation are distinct from those of conventional MAPKs such as ERK1/2. While ERK3 has been shown to be upregulated in lung cancers and head and neck cancers, in which it promotes cancer cell migration and invasion, little is known about the implication of ERK3 in NMSCs. "
3.	Head and Neck Neoplasms (Head and Neck Cancer) 01/01/2017 - "Taken together, our study revealed a molecular pathway consisting of BMI1, miRNA let-7i, and ERK3, which controls the migration of head and neck cancer cells, and suggests that ERK3 kinase is a potential new therapeutic target in head and neck cancers, particularly those with BMI1 overexpression." 02/12/2021 - "Extracellular signal-regulated kinase 3 (ERK3) is an atypical mitogen-activated protein kinase (MAPK) whose biochemical features and cellular regulation are distinct from those of conventional MAPKs such as ERK1/2. While ERK3 has been shown to be upregulated in lung cancers and head and neck cancers, in which it promotes cancer cell migration and invasion, little is known about the implication of ERK3 in NMSCs. "
4.	Neoplasm Metastasis (Metastasis) 01/01/2023 - "Extracellular signal-regulated kinase 3 (ERK3) promotes cell migration and tumor metastasis in multiple cancer types, including lung cancer. " 01/01/2019 - "Mitogen-activated protein kinase 6 (MAPK6) represents an atypical MAPK also known as extracellular signal-regulated kinase 3 (ERK3), which has been shown to play roles in cell motility and metastasis. "
5.	Carcinogenesis 01/01/2022 - "Extracellular signal-regulated kinase 3 (ERK3) is an atypical member of the mitogen-activated protein kinase (MAPK) family, members of which play essential roles in diverse cellular processes during carcinogenesis, including cell proliferation, differentiation, migration, and invasion. "

Related Drugs and Biologics

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2.	Mitogen-Activated Protein Kinase 6
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4.	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)
5.	alpha-Crystallin B Chain
6.	Organic Anion Transporters
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9.	Serpins
10.	Transcription Factors (Transcription Factor)