TNF Receptor-Associated Factor 5

A signal transducing tumor necrosis factor receptor associated factor that mediates signaling from CD27 ANTIGENS; CD40 ANTIGENS; and the LYMPHOTOXIN BETA RECEPTOR. It is involved in regulation of NF-KAPPA B signaling.

Also Known As:

Networked: 73 relevant articles (7 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	So, Takanori: 8 articles (01/2022 - 04/2004)
2.	Ishii, Naoto: 7 articles (01/2022 - 05/2014)
3.	Nagashima, Hiroyuki: 5 articles (01/2022 - 05/2014)
4.	Okuyama, Yuko: 5 articles (01/2022 - 05/2014)
5.	Asao, Atsuko: 5 articles (10/2020 - 05/2014)
6.	Kawabe, Takeshi: 4 articles (10/2020 - 05/2014)
7.	Kobayashi, Shuhei: 4 articles (10/2020 - 01/2018)
8.	Phung, Hai The: 4 articles (10/2020 - 01/2018)
9.	Nakano, Hiroyasu: 4 articles (05/2014 - 04/2004)
10.	Bode, Christoph: 3 articles (10/2021 - 09/2010)

Related Diseases

1.	Colitis 12/01/2023 - "TRAF5 regulates Th1 and Th17 cell differentiation and immune response through Runx1 to participate in the pathogenesis of colitis. " 12/01/2023 - "Mechanistically, knockout Runx1 inhibited the differentiation of TRAF5-/- CD4+ T cells into Th1 and Th17 cells in the intestinal mucosa of T-cell transfer colitis mice. " 12/01/2023 - "TRAF5-/- CD4+ CD45RBhigh T cells and WT CD4+ CD45RBhigh T cells were transferred to Rag2-/- mice via intravenous (i.v.) tail injection, respectively, to establish a chronic colitis model. " 12/01/2023 - "TRAF5 regulates intestinal mucosal Th1/Th17 cell immune responses via Runx1 in colitis mice." 10/01/2020 - "Experiments with bone marrow chimeras confirmed that TRAF5 deficiency in nonhematopoietic cells caused the attenuated colitis. "
2.	Atherosclerosis 07/01/2023 - "Silencing of TRAF5 abolished the protective effects of SNHG16 knockdown on the pathogenesis of atherosclerosis. " 09/17/2010 - "This study tested the hypothesis that TRAF5 modulates atherogenesis in vivo. " 07/01/2023 - "Collectively, PCSK9 inhibitor attenuated atherosclerosis by regulating SNHG16/EZH2/TRAF5 axis to impair the proliferation, migration, and foam cell formation of VSMC." 07/01/2023 - "PCSK9 inhibitor attenuates atherosclerosis by regulating SNHG16/EZH2/TRAF5-mediated VSMC proliferation, migration, and foam cell formation." 01/01/2023 - "Identification of necroptosis-related gene TRAF5 as potential target of diagnosing atherosclerosis and assessing its stability."
3.	Hypoxia (Hypoxemia) 01/01/2019 - "Moreover, knockdown of TRAF5 knockdown potentiated the protective effects of miR-29b-3p against hypoxia-induced cell injury. " 07/05/2020 - "This study demonstrates that the expression of TRAF5 is significant up-regulation in heart tissues of I/R injury mice and hypoxia/reoxygenation (H/R)-stimulated cardiomyocytes. " 12/01/2020 - "MiR-27a-3p restoration enhanced cell viability, depleted cell apoptosis and promoted glycolysis of hypoxia-induced AC16 cells, while these effects were abolished by TRAF5 overexpression. " 10/01/2019 - "MiRNA-410-3p protects hypoxia-induced proliferation suppression and apoptosis stimulation in cardiomyocytes via targeting TRAF5." 10/01/2019 - "Overexpression of miRNA-410-3p protects hypoxia-induced cardiomyocyte injury via targeting TRAF5."
4.	Inflammation (Inflammations) 10/01/2021 - "Inhibition of SNHG7 ameliorated neuronal apoptosis in PD through relieving miR-425-5p/TRAF5/NF-κB signaling pathway modulated inflammation and oxidative stress, and similar results were observed in the Rot-mediated rat model of PD." 07/05/2020 - "Further, TRAF5 overexpression inhibites inflammation and apoptosis of H/R-stimulated cardiomyocytes. " 10/01/2021 - " Approach and Results: To induce diet-induced obesity and adipose tissue inflammation, wild-type or Traf5-/- mice consumed a high-fat diet for 18 weeks. " 10/01/2021 - "Here, we tested the hypothesis that an impairment of TRAF5 signaling modulates adipose tissue inflammation and its metabolic complications in a model of diet-induced obesity in mice. " 10/01/2021 - "Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice."
5.	Melanoma (Melanoma, Malignant) 11/01/2020 - "Our results revealed that down-regulated HDAC3 elevates miR-495-3p to suppress malignant phenotypes of melanoma cells by inhibiting TRAF5, thereby repressing EMT progression of melanoma cells. " 11/01/2020 - "Inhibited HDAC3 elevated miR-495-3p to suppress EMT and oncogenicity of melanoma cells by reducing TRAF5. " 11/01/2020 - "HDAC3 and TRAF5 were increased while miR-495-3p was decreased in melanoma cells and tissues, and the low expression of miR-495-3p as well as high expression of HDAC3 indicated a poor prognosis of melanoma patients. " 11/01/2020 - "Down-regulated HDAC3 elevates microRNA-495-3p to restrain epithelial-mesenchymal transition and oncogenicity of melanoma cells via reducing TRAF5." 11/01/2020 - "Levels of HDAC3, miR-495-3p and TRAF5 in melanoma tissues and pigmented nevus tissues were determined, and the predictive roles of HDAC3 and miR-495-3p in prognosis of melanoma patients were measured. "

Related Drugs and Biologics

1.	TNF Receptor-Associated Factor 2 (TRAF2)
2.	Dextran Sulfate
3.	TNF Receptor-Associated Factor 6 (TRAF6)
4.	TNF Receptor-Associated Factor 4
5.	Tretinoin (Retinoic Acid)
6.	TNF Receptor-Associated Factor 3
7.	Cyclin D1
8.	Elements
9.	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
10.	TNF Receptor-Associated Factor 5

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Intranasal Administration