TNF Receptor-Associated Factor 2 (TRAF2)

A signal transducing tumor necrosis factor receptor associated factor that is involved in TNF RECEPTOR feedback regulation. It is similar in structure and appears to work in conjunction with TNF RECEPTOR-ASSOCIATED FACTOR 1 to inhibit APOPTOSIS.

Also Known As:

Networked: 317 relevant articles (8 outcomes, 30 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Habelhah, Hasem: 8 articles (04/2016 - 01/2004)
2.	Blackwell, Ken: 6 articles (04/2016 - 01/2009)
3.	Zhang, Laiqun: 6 articles (04/2016 - 01/2009)
4.	Mann, Douglas L: 5 articles (03/2022 - 01/2010)
5.	Li, Jun: 4 articles (01/2020 - 02/2015)
6.	Beckers, Linda: 4 articles (01/2019 - 05/2008)
7.	Lutgens, Esther: 4 articles (01/2019 - 05/2008)
8.	Evans, Sarah: 3 articles (03/2022 - 02/2014)
9.	Zhang, Fan: 3 articles (01/2022 - 01/2021)
10.	Sun, Shao-Cong: 3 articles (01/2021 - 05/2005)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "Dysregulated expression of TRAF2 has been reported in a variety of human cancers. " 01/01/2023 - "Altogether, we demonstrate that cIAP1/TRAF2 binding is essential to promote tumor growth via the activation of the JAK/STAT3 signaling pathway." 01/01/2023 - "Further, cIAP1 mediated the clustering of TRAF2, which was sufficient to stimulate tumor growth. " 01/01/2023 - "cIAP1/TRAF2 interplay promotes tumor growth through the activation of STAT3." 08/22/2022 - "In this review, we summarize the various TRAF2-related signaling pathways and their relevance for the oncogenic and tumor suppressive activities of TRAF2. "
2.	Colitis 10/01/2023 - "Celastrol activates mitochondrial autophagy through Nur77-TRAF2-p62/SQSTM1 pathway in the treatment of experimental colitis." 01/01/2013 - "Moreover, higher expression of TRAF2 was a predictor of relapse in patients with UC (p=0.006).Thus, protein expression profiles can distinguish IBD and nonspecific colitis, and combination analysis protein expression profiles show that TRAF2 can predict relapse of UC." 01/07/2015 - "Here we show that myeloid cell-specific ablation of TRAF2 greatly promotes TLR-stimulated proinflammatory cytokine expression in macrophages and exacerbates colitis in an animal model of inflammatory bowel disease. " 10/01/2020 - "TRAF5 Deficiency Ameliorates the Severity of Dextran Sulfate Sodium Colitis by Decreasing TRAF2 Expression in Nonhematopoietic Cells." 01/01/2020 - "Correction: TRAF5 Deficiency Ameliorates the Severity of Dextran Sulfate Sodium Colitis by Decreasing TRAF2 Expression in Nonhematopoietic Cells."
3.	Inflammation (Inflammations) 01/01/2019 - "TRAF2 regulator in ERK1/2-COX-2 inhibition significantly reduced inflammation, thus suggesting ESWT may be a potential and promising treatment for CP/CPPS." 04/01/2023 - "These data suggest that TSG-6 administration can effectively suppress the proliferation of HSFs in part via the inhibition of IRE1α-mediated ER stress-induced inflammation (IRE1α/TRAF2/NF-κB signalling)." 03/01/2022 - "TRAF2, an Innate Immune Sensor, Reciprocally Regulates Mitophagy and Inflammation to Maintain Cardiac Myocyte Homeostasis." 04/01/2021 - "Overexpression of TRAF2 could weaken the promotion effects of high miR-671 expression on cell progression and inflammation in IL-1β induced CHON-001 cells. " 07/01/2020 - "TRAF2 participates in the activation of both canonical and non-canonical NF-κB pathways, which are crucial for cell inflammation and cell survival. "
4.	Stroke (Strokes) 01/01/2019 - "Gene knockdown of TRAF2 by lentivirus was utilized to investigate the role of TRAF2 in stroke outcomes. " 01/01/2023 - "While previous studies reported that response to myocardial infarction and reperfusion was improved in the TRAF2 overexpressed mice, we found that TRAF2 mice had significantly lower cardiac systolic velocities and accelerations, diastolic atrial velocity, aortic pressures, rate-pressure product, LV contractility and relaxation, and stroke work when compared to littermate control mice. " 01/01/2019 - "In this study, we investigated the role of TRAF2 in experimental stroke using a mouse middle cerebral artery occlusion (MCAO) model and in vitro cellular models. " 01/03/2022 - "SNHG15 is a negative regulator of inflammation by mediating TRAF2 ubiquitination in stroke-induced immunosuppression." 10/01/2021 - "However, no other circRNA polymorphisms (circ-DLGAP4 rs41274714, circ-TRAF2 rs10870141, circ-ITCH rs10485505, rs4911154) were associated with functional outcome 3 months after stroke in any genetic models. "
5.	Infections 08/01/2020 - "Taken collectively, these results have improved our understanding of the functions of TRAF2, TRAF7, and TRADD in pathogenic infections in teleosts." 11/30/2023 - "In conclusion, by screening natural compounds, we found that SC suppresses PRRSV infection by regulating the TRAF2/NF-κB signalling pathway. " 07/01/2020 - "Fish TRAF2 promotes innate immune response to RGNNV infection." 07/16/2014 - "LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria." 11/30/2023 - "The natural compound Sanggenon C inhibits PRRSV infection by regulating the TRAF2/NF-κB signalling pathway."

Related Drugs and Biologics

1.	TNF Receptor-Associated Factor 5
2.	Dextran Sulfate
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	TNF Receptor-Associated Factor 4
5.	NF-kappa B (NF-kB)
6.	Ligands
7.	wogonoside
8.	Proteins (Proteins, Gene)
9.	TNF Receptor-Associated Factor 2 (TRAF2)
10.	Interleukin-8 (Interleukin 8)

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy
3.	Prostatectomy (Retropubic Prostatectomy)
4.	Ligation
5.	Lasers (Laser)