TNF Receptor-Associated Factor 2 (TRAF2)

A signal transducing tumor necrosis factor receptor associated factor that is involved in TNF RECEPTOR feedback regulation. It is similar in structure and appears to work in conjunction with TNF RECEPTOR-ASSOCIATED FACTOR 1 to inhibit APOPTOSIS.

Also Known As:

Networked: 130 relevant articles (2 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Habelhah, Hasem: 7 articles (10/2015 - 01/2004)
2.	Blackwell, Ken: 5 articles (10/2015 - 01/2009)
3.	Zhang, Laiqun: 5 articles (10/2015 - 01/2009)
4.	Wang, Jian: 3 articles (11/2015 - 06/2013)
5.	Mann, Douglas L: 3 articles (01/2015 - 01/2010)
6.	Weber, Christian: 3 articles (02/2014 - 05/2008)
7.	Lievens, Dirk: 3 articles (02/2014 - 05/2008)
8.	Beckers, Linda: 3 articles (02/2014 - 05/2008)
9.	Lutgens, Esther: 3 articles (02/2014 - 05/2008)
10.	Nakano, Hiroyasu: 3 articles (10/2012 - 01/2009)

Related Diseases

1.	Neoplasms (Cancer) 01/08/2015 - "Cancer cells that are dependent on TRAF2 also require NF-κB for survival. " 01/08/2015 - "Suppression of TRAF2 in cancer cells harboring TRAF2 copy number gain inhibits proliferation, NF-κB activation, anchorage-independent growth and tumorigenesis. " 01/08/2015 - "TRAF2 is an NF-κB-activating oncogene in epithelial cancers." 01/01/2013 - "Our data indicates that the TRAF2/NIK/NF-κB2 pathway regulates PDAC cell tumorigenicity and could be a valuable target for therapy of this cancer." 12/01/2012 - "These results reveal a critical role for the MAPK8 activation pathway through TRAF2 and RIPK1 for TNFSF10-induced autophagy that blunts apoptosis in cancer cells. "
2.	Melanoma (Melanoma, Malignant) 04/26/2001 - "Here we demonstrate that expression levels of signal adaptor protein TRAF2 coincide with melanoma resistance to UV-irradiation. " 02/17/2000 - "Our results illustrate a mechanism in which protection from, or promotion of, UV-induced melanoma cell death depends on the nature of the apoptotic cascade (TNF or Fas) and on the availability of TRAF2/GCK, whose expression increases during melanoma progression. " 02/17/2000 - "Here we demonstrate that changes in the expression and respective activities of TRAF2/GCK occur during melanoma development and regulate its sensitivity to UV-induced apoptosis. " 02/17/2000 - "Role of TRAF2/GCK in melanoma sensitivity to UV-induced apoptosis." 02/17/2000 - "Comparing early- and late-stage melanoma cells revealed low expression of TRAF2 and GCK in early-stage melanoma, which coincided with poor resistance to UV-induced, TNF-mediated apoptosis; forced expression of GCK alone or in combination with TRAF2 efficiently increased JNK and NF-kappaB activities, which coincided with increased protection against apoptosis. "
3.	Necrosis 02/01/2001 - "The tumour necrosis factor pathway was activated in AN and AA with increased cytokine and receptor levels and increased TRAF2, an intracellular signalling product. " 05/15/2009 - "Recruitment of a TRAF2 (tumour necrosis factor receptor-associated factor 2)-c-IAP1 complex to the cytoplasmic domain of the Hodgkin's/anaplastic large-cell lymphoma-associated receptor, CD30, leads to the targeting and degradation of the TRAF2-c-IAP1 heterodimer through a mechanism requiring the RING (really interesting new gene) domain of TRAF2, but not c-IAP1. " 02/01/2015 - "Furthermore, we demonstrated that GOLPH3 promoted K63-linked polyubiquitination of tumour necrosis factor receptor-associated factor 2 (TRAF2), receptor interacting protein (RIP) and NF-κB essential modulator (NEMO) and substantially sustained the activation of NF-κB in HCC cells. " 08/14/2003 - "CYLD also interacts directly with tumour-necrosis factor receptor (TNFR)-associated factor 2 (TRAF2), an adaptor molecule involved in signalling by members of the family of TNF/nerve growth factor receptors. " 01/01/2015 - "We constructed a homozygous mutant mouse ES cell line in the Traf2 gene that is known to play a role in tumour necrosis factor-α signalling but has not been studied for its role in infections or response to Toll-like receptor agonists. "
4.	Inflammation 12/01/2013 - "EI24 attenuated NF-κB activity by binding to the Complex I component TRAF2 and inducing its lysosome-dependent degradation, leading to transcriptional alterations of EMT- and inflammation-related genes. " 06/01/2013 - "Our results strongly suggest that the reduction of Parkin or overexpression of TRAF2/6 by chronic inflammation would be the reason for occurrence of PD." 06/01/2013 - "Here, we provide the evidence that Parkin suppresses inflammation and cytokine-induced cell death by promoting the proteasomal degradation of TRAF2/6 (TNF-α receptor-associated factor 2/6). " 10/01/2012 - "These results suggest that the development of IL-10-secreting neutrophils is not restricted to Traf2(-/-) mice, but could be generalized to wild-type mice under certain conditions such as inflammation. " 11/08/2011 - "Our results suggest that a regulatory circuit consisting of TRAF2-NFκB-induced kinase-NFκB2p52 is essential for the proper control of effector T-cell polarization and that loss of T-cell TRAF2 function induces constitutive NFκB2p52 activity that drives fatal autoimmune inflammation independently of TNFα signaling. "
5.	Infection 01/01/2014 - "LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria." 08/01/2000 - "In this study, using isothermal titration calorimetry (ITC), we report thermodynamic characterization of the interaction between TRAF2 and monomeric peptide sequences from TNFR members, including TNFR2, CD40, CD30, Ox40, and 4-1BB, and the Epstein-Barr virus (EBV)-transforming protein, latent infection membrane protein-1 (LMP1). " 10/01/2015 - "In conclusion, the HPV16 infection in keratinocytes causes a switch of apoptotic to proliferative fate under TWEAK/Fn14 interaction, possibly by favoring Ras and TRAF2 activation and modulating TNF receptor expression. " 04/01/2014 - "In single-cycle infections, there was delayed production of both early and late VACV proteins as well as accelerated virus-induced alterations to cell morphology, indicating that TRAF2 influences early stages of virus replication. " 04/01/2014 - "Loss of TRAF2 expression, either through small interfering RNA treatment of HeLa cells or through genetic knockout in murine embryonic fibroblasts (MEFs), led to significant reductions in VACV growth following low-multiplicity infection. "

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	NF-kappa B (NF-kB)
3.	TNF Receptor-Associated Factor 2 (TRAF2)
4.	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
5.	Type II Tumor Necrosis Factor Receptors
6.	TNF Receptor-Associated Factor 4
7.	TNF-Related Apoptosis-Inducing Ligand Receptors
8.	OX40 Ligand
9.	Proteasome Endopeptidase Complex (Proteasome)
10.	Interleukin-8 (Interleukin 8)

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