TNF Receptor-Associated Factor 1

A signal transducing tumor necrosis factor receptor associated factor that is involved in TNF RECEPTOR feedback regulation. It is similar in structure and appears to work in conjunction with TNF RECEPTOR-ASSOCIATED FACTOR 2 to inhibit APOPTOSIS.

Also Known As:

Networked: 196 relevant articles (3 outcomes, 32 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Watts, Tania H: 7 articles (01/2021 - 06/2008)
2.	Tsitsikov, Erdyni N: 6 articles (06/2008 - 06/2005)
3.	Edilova, Maria I: 4 articles (01/2021 - 01/2017)
4.	Wang, Chao: 4 articles (01/2021 - 01/2012)
5.	Kremmer, Elisabeth: 4 articles (01/2018 - 11/2004)
6.	Plenge, Robert M: 4 articles (01/2015 - 09/2007)
7.	Gregersen, Peter K: 4 articles (09/2011 - 09/2007)
8.	Abdul-Sater, Ali A: 3 articles (01/2021 - 01/2017)
9.	Bu, Guangkui: 3 articles (01/2015 - 09/2012)
10.	Shen, Shourong: 3 articles (01/2015 - 09/2012)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2000 - "These findings contribute to an improved understanding of the cell-specific roles of TRAFs in normal tissues and provide evidence of altered TRAF1 expression in lymphoid malignancies." 09/01/2001 - "In vitro, TRAF1 is induced by LMP1, and previous studies have suggested that expression of TRAF1 is higher in EBV-associated tumors than in their EBV-negative counterparts. " 01/01/2021 - "Little has been done to assess the role of TRAF1 in human cancer. " 01/01/2018 - "The only genes showing heterogeneity between ER- and ER+ cancers were TRAF1, MAP3K1, and MAPK3 (P ≤ 0.02). " 10/31/2017 - "TXNDC5 is a cervical tumor susceptibility gene that stimulates cell migration, vasculogenic mimicry and angiogenesis by down-regulating SERPINF1 and TRAF1 expression."
2.	Infections 01/01/2020 - "Herein, we reveal that TRAF1 suppresses the antifungal immune response to Candida albicans intradermal infection through the regulation of CXCL1 induction and neutrophil recruitment. " 01/01/2020 - "TRAF1 suppresses antifungal immunity through CXCL1-mediated neutrophil recruitment during Candida albicans intradermal infection." 12/28/2016 - "pylori infection significantly inhibits the cleavage of TRAF1 via a CagA-dependent mechanism, which would increase the relative amounts of full-length TRAF1 and exert an antiapoptotic effect on H. " 12/28/2016 - "pylori infection on TRAF1 cleavage was detected in the presence of apoptosis inducer. " 12/01/2016 - "pylori infection induces the overexpression of TRAF1 in gastric epithelial cells. "
3.	Rheumatoid Arthritis 04/14/2011 - "This study investigated the association between single nucleotide polymorphisms (SNPs) in TRAF1/C5 and PTPN22 genes and rheumatoid arthritis (RA) in a Han Chinese population. " 04/20/2023 - "SNP in PTPN22, PADI4, and STAT4 but Not TRAF1 and CD40 Increase the Risk of Rheumatoid Arthritis in Polish Population." 09/01/2022 - "CD40/TRAF1 decreases synovial cell apoptosis in patients with rheumatoid arthritis through JNK/NF-κB pathway." 09/17/2019 - "Objective: To investigatea cellular/molecular mechanism of the CD40/TRAF1 signalling pathway involved in Rheumatoid arthritis (RA). " 09/17/2019 - "[CD40/TNF receptor associated factor 1 expression and NF-κB-dependent proinflammatory gene expression in rheumatoid arthritis]."
4.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/01/2012 - "Gene-gene interaction of BLK, TNFSF4, TRAF1, TNFAIP3, and REL in systemic lupus erythematosus." 03/15/2013 - "Association study of TRAF1/C5 polymorphism (rs10818488) with susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis." 06/01/2008 - "The aim of this study was to determine the influence of STAT4 (rs7574865) and TRAF1/C5 (rs10818488 and rs2900180) gene polymorphisms on the risk of developing rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in a Colombian population. " 01/01/2016 - "Association of the polymorphisms of TRAF1 (rs10818488) and TNFAIP3 (rs2230926) with rheumatoid arthritis and systemic lupus erythematosus and their relationship to disease activity among Egyptian patients." 12/01/2011 - "TRAF1/C5, eNOS, C1q, but not STAT4 and PTPN22 gene polymorphisms are associated with genetic susceptibility to systemic lupus erythematosus in Turkey."
5.	Inflammation (Inflammations) 01/01/2019 - "Importantly, the in vitro study suggested that promoting JNK activation markedly abrogated TRAF1 knockdown-attenuated inflammation, ROS production and apoptosis in LPS-exposed A549 cells. " 02/01/2023 - "Collectively, our findings suggest that UVB and IFN-ɑ downregulate miR-885-5p in CLE KCs, leading to epidermal inflammation by NF-κB activity enhancement and proliferation through PSMB5 and immune recruitment through TRAF1. " 10/01/2022 - "LINC00313 overexpression or TRAF1 silencing attenuated IL-1β-induced viability inhibition, apoptosis, inflammation and ECM degradation in CHON-001 cells. " 01/01/2021 - "MSC-Exo can ameliorate SSRA by moderating inflammation, which is achieved by reshaping macrophage polarization via inhibition of TRAF1." 11/05/2019 - "We demonstrated that TRAF1 deficiency protects against myocardial I/R-induced loss of heat function, inflammation, and cardiomyocyte death. "

Related Drugs and Biologics

1.	Ligands
2.	Interleukin-7 (Interleukin 7)
3.	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
4.	Proteins (Proteins, Gene)
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	TNF Receptor-Associated Factor 1
7.	Complement C5 (Complement 5)
8.	HLA-DRB1 Chains (HLA DRB1)
9.	Inflammasomes
10.	Phorbol Esters

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
4.	Transplantation
5.	Immunotherapy