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Pituitary ACTH Hypersecretion

Subscribe to New Research on Pituitary ACTH Hypersecretion

A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.

Also Known As:

Adrenocorticotropic Hormone, Inappropriate Secretion; ACTH Hypersecretion, Pituitary; Disease, Cushing; Hypersecretion, Pituitary ACTH; Cushing Disease; Inappropriate ACTH Secretion Syndrome; Inappropriate Adrenocorticotropic Hormone Secretion

Networked: 281 relevant articles (34 outcomes, 21 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cushing Syndrome
2.	Adenoma (Adenomas)
3.	Neoplasms (Cancer)
4.	Pituitary Neoplasms (Pituitary Adenoma)
5.	Acromegaly

Experts

1.	Stratakis, Constantine A: 6 articles (07/2015 - 09/2005)
2.	Hamrahian, Amir H: 4 articles (10/2015 - 01/2011)
3.	Melmed, Shlomo: 4 articles (07/2015 - 11/2002)
4.	Swearingen, Brooke: 4 articles (10/2012 - 05/2011)
5.	Weil, Robert J: 3 articles (10/2015 - 01/2011)
6.	Ben-Shlomo, Anat: 3 articles (07/2015 - 05/2011)
7.	Shah, Nalini S: 3 articles (02/2015 - 11/2010)
8.	Yamada, Shozo: 3 articles (04/2014 - 01/2002)
9.	Lodish, Maya B: 3 articles (04/2014 - 06/2009)
10.	Sinaii, Ninet: 3 articles (04/2014 - 06/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pituitary ACTH Hypersecretion:

1.	Adrenocorticotropic Hormone (ACTH)FDA Link 05/01/2012 - "Bilateral inferior petrosal sinus sampling, the gold standard assay in diagnosing pituitary secretion of adrenocorticotropic hormone in Cushing disease, is highly accurate and safe when performed by experienced interventionalists. " 01/01/2005 - "Postoperatively, her serum ACTH concentration dropped below 5 pg/ml. In this case, inferior petrosal sinus sampling was extremely helpful for the diagnosis of Cushing disease, and operations were able to be performed safely using the neuronavigation system in drilling of the incompletely pneumatized sphenoid sinus." 09/01/1993 - "The CS/peripheral (CS/P) ratio of ACTH (mean = 66.1) was significantly greater than the IPS/peripheral (IPS/P) ratio (mean = 14.9) in Cushing disease. " 06/01/2009 - "Although numerous studies have shown that transsphenoidal surgery is the best initial treatment for Cushing disease offering 59-95% of success, fewer information is available on the long-term outcome in the subgroup of patients harboring ACTH-secreting macroadenomas. " 04/01/2014 - "This case series conducted at the National Institutes of Health Clinical Center included 93 children with Cushing disease (CD) (43 females; mean age, 12.3 ± 2.9 years) and 31 children with adrenocorticotropic hormone-independent CS (AICS) (22 females, mean age 10.3 ± 4.5 years). "
2.	Hydrocortisone (Cortisol)FDA LinkGeneric 04/01/2012 - "Subnormal postoperative serum cortisol levels indicate successful surgery and predict long-term remission of Cushing disease. " 01/01/2004 - "Remission (normalization of 24-hour urine-free cortisol (UFC) and its metabolites) was achieved in one patient with Cushing disease. " 11/01/2003 - "Remission (normalization of 24-hour urine-free cortisol (UFC) and its metabolites) was achieved in one patient with the Cushing disease. " 02/01/2015 - "The performance and reproducibility of late-night salivary cortisol estimation by enzyme immunoassay for screening cushing disease." 01/01/2007 - "Cushing disease: use of perioperative serum cortisol measurements in early determination of success following pituitary surgery."
3.	HormonesIBA 06/01/2005 - "Endocrinological remission occurred in 57% of patients undergoing RTSS to treat hormone hypersecretion; most of these patients had Cushing disease. " 09/01/2015 - "Bilateral inferior petrosal sinus sampling (BIPSS) following corticotropic-releasing hormone (CRH) stimulation is the current gold standard technique in the diagnosis of Cushing disease. " 07/01/1966 - "[A study of the biosynthesis of steroid hormones in vitro in the adrenal cortex in Itsenko-Cushing disease]." 04/01/2014 - "These findings demonstrate that the FGFR4 transmembrane polymorphic variants can modulate cellular growth and sensitivity to glucocorticoid hormone negative feedback through distinct STAT3 modifications of relevance to the human forms of Cushing disease. " 12/01/2012 - "However, given the potential for recovery of thyroid function following cure of Cushing disease, we recommend withholding thyroid hormone replacement until after pituitary surgery."
4.	cabergoline FDA LinkGeneric 05/01/2008 - "Remission in Cushing disease with cabergoline." 08/01/2013 - "Cabergoline can be used to manage Cushing disease successfully during pregnancy with an opportunity for a favorable outcome." 08/01/2013 - "Cabergoline therapy for Cushing disease throughout pregnancy." 11/01/2010 - "Cabergoline was an effective therapy in 28%, 25%, and 17% of patients with uncured Cushing disease in terms of LDSC or MNSC (or both), LDSC alone, and MNSC alone, respectively. " 11/01/2010 - "To evaluate the efficacy of cabergoline therapy in patients with Cushing disease who remained uncured (had persistent or recurrent disease) after a pituitary surgical procedure with or without radiotherapy. "
5.	Dexamethasone (Maxidex)FDA LinkGeneric 11/01/1988 - "Stages of body responses to small doses of dexamethasone (the stage of lost responses, the stage of incomplete loss and the stage of recovered responses) were identified contributing to objective assessment of the gravity, course, presence, recurrence and remission of Itsenko-Cushing disease." 03/01/2012 - "To determine the utility of high-dose dexamethasone suppression (HDDS) tests to confirm the diagnosis of Cushing disease (CD). " 03/01/2012 - "Assessment of the utility of the high-dose dexamethasone suppression test in confirming the diagnosis of Cushing disease." 05/01/2003 - "Transsphenoidal microsurgical treatment of Cushing disease: postoperative assessment of surgical efficacy by application of an overnight low-dose dexamethasone suppression test." 07/20/1995 - "We made a diagnosis of Cushing disease with dexamethasone suppression test, CRF stimulation test, venous sampling, and MRI scan. "
6.	Protons (Proton)IBA 08/01/1987 - "Thus the results of proton beam therapy of 98 patients with Icenko-Cushing disease after a follow-up of 3-5 years showed a high efficacy of this type of treatment. " 01/01/1990 - "[The efficacy of proton irradiation of the hypophysis in children with Itsenko-Cushing disease]." 01/01/1991 - "[The effect of proton therapy on the protein-amino acid metabolism in Itsenko-Cushing disease]." 01/01/1990 - "The authors represent the results of the treatment of 20 children with Itsenko-Cushing disease (ICD) by proton-beam irradiation of the pituitary body. " 09/01/1989 - "[Adenohypophysis function in Itsenko-Cushing disease before and after proton-beam irradiation]."
7.	ProlactinIBA 03/01/2015 - "This article discusses some of the recent studies reporting outcomes from endoscopic series for Cushing disease, acromegaly, prolactin-secreting tumors, and nonfunctioning macroadenomas. " 02/01/2003 - "At a median follow-up period of 16 months (range 3-45 months), surgical remission rates were as follows: in 40 patients with endocrine-inactive macroadenomas, 95% for noninvasive and 40% for invasive tumors; in the 20 patients with prolactinomas, 75% for prolactinomas with an initial prolactin (PRL) level lower than 200 ng/ml, 33% for those with a PRL level between 200 and 600 ng/ml, and 0% for those with a PRL level higher than 1400 ng/ml; in the 15 patients with Cushing disease, 73% for microadenomas and 25% for macroadenomas; in the 10 patients with acromegaly, 75% for microadenomas and 50% for macroadenomas; in the five patients with Rathke cleft cysts, 80%; and in the five patients with craniopharyngiomas, 40%. " 01/01/2011 - "Measurement of prolactin during IPSS testing may reduce false-negative results in patients with Cushing disease who do not demonstrate an appropriate central-to-peripheral ACTH gradient. " 03/01/1991 - "[The gonadotropin, prolactin and sex steroid content of the blood from the inferior cavernous sinuses and the adrenal and ovarian veins of women with Itsenko-Cushing disease]." 07/01/1984 - "[Interrelation of disorders in gonadotropin and prolactin secretion and the activity of the hypothalamo-hypophyseal-adrenal system in Itsenko-Cushing disease]."
8.	Cyproheptadine (Periactin)FDA Link 03/01/1983 - "[Potential use of the antiserotonin preparation cyproheptadine (peritol) in Itsenko-Cushing disease]." 05/01/1977 - "Treatment of Cushing disease in Childhood with cyproheptadine." 06/01/1984 - "Prolonged remission of Cushing disease after treatment with cyproheptadine." 01/01/1985 - "The study showed a different sensitivity of patients with Icenko-Cushing disease to peritol and parlodel. " 10/01/1983 - "[Function of the hypophysis in patients with Itsenko-Cushing disease treated with peritol and chloditan]."
9.	Bromocriptine (Parlodel)FDA LinkGeneric 06/01/1978 - "[Clinical and biochemical remission of Itsenko-Cushing disease during parlodel treatment]." 01/01/1985 - "The study showed a different sensitivity of patients with Icenko-Cushing disease to peritol and parlodel. " 01/01/1991 - "A patient suffering Cushing disease is presented in whom the administration of ciproheptadine, bromocriptine and sodium valproate in a single dose did not manage to control the clinical-biologic manifestations of the process. " 09/01/1988 - "The results of investigation of the secretion of hypophyseal, adrenal and renal hormones resulting from parlodel administration in 44 patients with Itsenko-Cushing disease were discussed. " 09/01/1988 - "[Effect of a single dose of parlodel on the secretion of various hormones in Itsenko-Cushing disease]."
10.	alpha-Tocopherol FDA Link 07/01/1988 - "In Itsenko-Cushing disease an elevated level of lipid peroxidation products in plasma, erythrocytes, liver, muscular tissue, and a decrease in the level of alpha-tocopherol in erythrocytes against a background of its elevation in plasma were detected. " 07/01/1988 - "In patients with Itsenko-Cushing disease a study was made of the content of lipid hydroperoxides, malonic dialdehyde, alpha-tocopherol in plasma and erythrocytes (in 31 untreated patients, in 41 patients with recurrences, in 61 patients during clinical remission and in 14 patients after bilateral adrenalectomy), in tissue biopsy specimens: of the liver (13), muscles (23), fatty tissue (30). "

Therapies and Procedures

1.	Adrenalectomy 05/01/2011 - "Patients with persistent or recurrent Cushing disease might, therefore, benefit from a second pituitary operation (which leads to remission in 50-70% of cases), radiation therapy to the pituitary gland or bilateral adrenalectomy. " 02/01/1989 - "Data are reported of the functional state of the hypothalamoadrenal system in 119 women with Itsenko-Cushing disease in the active stage, stage of stable clinical remission and after total adrenalectomy. " 01/01/2008 - "Pituitary MRI study of patients with Cushing disease treated by adrenalectomy remains difficult. " 06/22/1955 - "[Cushing disease: clinical and biochemical study, effects of bilateral subtotal adrenalectomy]." 01/01/2014 - "Long-term outcomes of laparoscopic adrenalectomy for Cushing disease."
2.	Radiotherapy 07/01/2014 - "Medical therapy is usually not the first-line treatment for patients with Cushing disease but may be used to improve clinical manifestations of Cushing disease in patients who are not suitable candidates for surgery, following unsuccessful surgery or recurrence, or as a "bridge therapy" in those who have undergone radiotherapy. " 10/01/2012 - "Stereotactic radiation therapy has emerged as an alternative to conventional radiotherapy for treatment of Cushing disease. " 05/01/1963 - "[Radiological symptomatology and radiotherapy of a case of Cushing disease]." 09/01/2014 - "We are aware of only one previous case report of clinically significant hypercortisolism following radiotherapy in Cushing disease. " 11/01/2010 - "To evaluate the efficacy of cabergoline therapy in patients with Cushing disease who remained uncured (had persistent or recurrent disease) after a pituitary surgical procedure with or without radiotherapy. "
3.	Aftercare (After-Treatment) 12/01/2015 - "Cushing Disease After Treatment of Nonfunctional Pituitary Adenoma: A Case Report and Literature Review." 01/01/1992 - "[Remission of Itsenko-Cushing disease after treatment with nizoral]." 06/01/1984 - "Prolonged remission of Cushing disease after treatment with cyproheptadine." 03/01/2002 - "A 49-year-old man, diagnosed as having Cushing disease in 1976 at the age of 26, underwent a Hardy operation 13 years after treatment with reserpine combined with pituitary radiation. " 08/01/1982 - "[State of the skin in Itsenko-Cushing disease and hormonally active tumors of the adrenal cortex before and after treatment with chloditan]."
4.	Hormone Replacement Therapy (Therapy, Hormone Replacement) 01/01/2007 - "Transsphenoidal pituitary surgery is the primary therapy for Cushing disease because of its potential to produce lasting remission without the need for long-term drug or hormone replacement therapy. " 09/01/2014 - "At his current age of 26 years, his final height had attained the target level range; his bone mineral density was normal, and his pubic hair was Tanner stage 4. This report describes the long-term treatment course of a Cushing disease patient according to growth profile, pubertal status, and responses to hormone replacement therapy. "
5.	Combined Modality Therapy 01/01/2007 - "Some patients, however, will not achieve sustained remission after transsphenoidal surgery and can exhibit persistent or recurrent Cushing disease that requires multimodal treatment to achieve remission. "