Breast Cyst

A fluid-filled closed cavity or sac that is lined by an EPITHELIUM and found in the BREAST. It may appear as a single large cyst in one breast, multifocal, or bilateral in FIBROCYSTIC BREAST DISEASE.

Also Known As:

Networked: 263 relevant articles (6 outcomes, 41 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cysts
2.	Iron-Deficiency Anemia (Anemia, Iron Deficiency)
3.	Endometrial Neoplasms (Endometrial Cancer)
4.	Tubal Pregnancy
5.	Ovarian Neoplasms (Ovarian Cancer)

Experts

1.	Mannello, Ferdinando: 4 articles (06/2014 - 05/2006)
2.	Darbre, Philippa D: 3 articles (11/2013 - 01/2009)
3.	Darbre, P D: 2 articles (06/2016 - 11/2011)
4.	Mannello, F: 2 articles (11/2011 - 01/2001)
5.	Tonti, Gaetana A: 2 articles (04/2011 - 01/2009)
6.	Erbas, Hakan: 2 articles (02/2008 - 12/2007)
7.	Erten, Oya: 2 articles (02/2008 - 12/2007)
8.	Calandra, Ricardo S: 2 articles (01/2006 - 02/2003)
9.	Enriori, Pablo J: 2 articles (01/2006 - 02/2003)
10.	Etkin, Alberto E: 2 articles (01/2006 - 02/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Breast Cyst:

1.	Proteins (Proteins, Gene)FDA Link 01/01/1992 - "Improved "electrophoretic map" of breast cyst fluid proteins." 08/01/1989 - "In this study, we applied the antibody against the molecular weight 15,000 protein purified from breast cyst fluid (GCDFP-15) to cutaneous tissue, especially to sweat glands. " 08/01/1989 - "[An immunohistochemical study of normal sweat glands using an antibody to the breast cyst fluid protein (GCDFP-15)]." 06/01/1998 - "This high attenuation value is correlated with the high protein content of breast-cyst fluid. " 06/01/1998 - "Aspirate samples from 10 simple breast cysts were analyzed for protein content, and CT attenuation values were calculated by means of a breast phantom. "
2.	Epidermal Growth Factor (EGF)IBA 11/01/1985 - "The mean concentration of EGF is significantly greater in breast cyst fluid (241 +/- 143 ng/ml) and in colostrum (197 +/- 56 ng/ml) than in milk (107 +/- 22 ng/ml). " 09/01/1991 - "[Epidermal growth factor behavior in breast cyst fluid. " 01/01/1990 - "Epidermal growth factor in breast cyst fluids. " 11/01/1989 - "The mean levels of EGF were lower in plasma than in breast cyst fluid (BCF) (p less than 0.001). " 11/01/1989 - "Epidermal growth factor levels in human breast cyst fluid."
3.	Danazol (Azol)FDA LinkGeneric 09/01/1986 - "A controlled trial of danazol in the treatment of multiple recurrent breast cysts." 11/01/1989 - "Long-term follow up of patients treated with a single course of danazol for recurrent breast cysts." 11/01/1988 - "An insufficient number of patients presented with breast cysts to draw any conclusions regarding the efficacy of danazol on cysts. "
4.	CholesterolIBA 04/01/2002 - "In order to establish an improved method for assaying dehydroepiandrosterone sulfate (DHEAS) and cholesterol, which are the largest components of human breast cyst and duct fluids, we describe a simple, accurate, and sensitive method using high-performance liquid chromatography (HPLC). " 12/01/1994 - "The levels of total cholesterol and HDL-C were found to be significantly higher, and the levels of triglycerides and VLDL-C significantly lower in breast cyst fluid compared to serum. " 04/01/2002 - "Levels of free cholesterol, DHEAS, and DHEA in human breast cyst fluids (n = 30) were 1.77 +/- 1.12 mmol/dl, 8.27 +/- 10.24 micromol/dl, and 0.02 +/- 0.02 micromol/dl (means +/- SD), respectively. " 05/01/1992 - "The absence of a correlation between cholesterol concentration and apo D concentration and the results from previous binding analysis suggest that this protein is not involved in the accumulation of cholesterol in breast-cyst fluid." 12/01/1994 - "The study entailed measuring total cholesterol, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), very low-density lipoprotein-cholesterol (VLDL-C) and triglyceride levels in the serum of 50 women with fibrocystic breast disease without macrocysts, and in the serum and breast cyst fluid of 60 women with fibrocystic breast disease and macrocysts. "
5.	Dehydroepiandrosterone SulfateIBA 04/01/2002 - "A simple, accurate, and sensitive assay method of dehydroepiandrosterone sulfate: application for quantitative determination in human breast cyst and duct fluids." 07/01/1995 - "No relationship between mammographic patterns and characteristics of breast cyst fluid such as K+/Na+ ratio, apocrine changes and dehydroepiandrosterone sulfate concentration was observed. " 04/01/2002 - "In order to establish an improved method for assaying dehydroepiandrosterone sulfate (DHEAS) and cholesterol, which are the largest components of human breast cyst and duct fluids, we describe a simple, accurate, and sensitive method using high-performance liquid chromatography (HPLC). " 11/01/1982 - "Dehydroepiandrosterone sulfate (DHAS) has been measured by radioimmunoassay in 100 breast cyst fluids obtained from 82 women. " 08/01/1987 - "Breast cyst fluid is rich in androgens, particularly dehydroepiandrosterone sulfate; concentrations of polypeptide hormones like FSH, LH, TSH, PRL, and calcitonin are invariably present sometimes in less and at other times in greater amounts than that found in plasma. "
6.	Transforming Growth Factor beta (TGF-beta)IBA 07/01/1999 - "The aim of the present study was to characterise the latent forms of TGF-beta 2 in breast cyst fluid using HPLC, affinity chromatography, SDS-PAGE and immunostaining techniques. " 07/01/1999 - "Latent forms of transforming growth factor-beta 2 (TGF-beta 2) in breast cyst fluid." 12/20/1996 - "No difference was found in transforming-growth factor-beta 1 (TGF-beta1) levels between the two sub-groups of breast cysts. " 07/01/1999 - "Women who have palpable breast cyst with intracystic Na/K < 3 may have a higher risk of developing breast cancer than those with intracystic Na/K > 3. Finding of significantly higher concentrations of TGF-beta 2 in the Na/K > 3 group than Na/K < 3 group may explain the lower risk of breast cancer in the Na/K > 3 group. " 02/01/2008 - "The aim of this study was to investigate the presence of plasmin in both breast cyst groups and the possible role of plasmin on transforming growth factor beta activation. "
7.	Interleukin-6 (Interleukin 6)IBA 01/01/2016 - "Contrarily, the levels of visfatin/NAMPT and TNF-α were significantly increased, and IL-6 levels were similar in the breast cyst fluid and plasma in both study groups. " 03/01/1999 - "The concentration of TNF-alpha in breast cyst fluid was predicted statistically by a positive regression coefficient for the concentration of IL-6, and by a negative regression coefficient for the concentration of estradiol. " 03/01/1992 - "Interleukin-1 and interleukin-6 in breast cyst fluid: their role in regulating aromatase activity in breast cancer cells." 11/01/1994 - "Oncostatin M, interleukin 2, interleukin 6 and interleukin 8 in breast cyst fluid." 11/01/1994 - "In this study, the concentrations of the cytokines, oncostatin M (OSM), interleukin 2 (IL-2), interleukin 6 (IL-6) and interleukin 8 (IL-8) were measured in breast cyst fluid, OSM, IL-2 and IL-6 having been shown to have growth-inhibitory actions on tumour cells. "
8.	SteroidsIBA 10/01/1984 - "Particularly greater amounts of 5 alpha-reduced steroids are found in breast cysts. " 04/01/1984 - "Seeking a hormonal etiology to this correlation, investigators have analyzed breast cyst fluid ( BCF ) for steroids and have compared the levels to those in the blood. " 01/01/1995 - "Steroid metabolism by breast cysts may play a role in the development of breast cancer." 06/01/1994 - "Steroid biochemistry and categorization of breast cyst fluid: relation to breast cancer risk." 01/01/1992 - "Categorization of cysts and steroid levels in breast cyst fluid."
9.	ElectrolytesIBA 01/01/2001 - "Breast cysts are categorized into two groups (type I and type II) according to the concentration of electrolytes in the cyst fluid. " 08/31/1992 - "These data have confirmed preceding results and have clearly shown that breast cyst fluids with low electrolyte ratio contain more E2S than the other group. " 08/01/1987 - "Thus, the pH of breast cyst fluid appears to be related to the electrolyte profile." 03/01/1985 - "All breast cysts aspirated from a series of 100 patients followed for a minimum period of 2 years were classified on the basis of electrolyte composition as apocrine or flattened, this being the nature of the epithelium lining the two populations of breast cysts. " 05/01/1979 - "Electrolytes of breast-cyst fluid."
10.	Hormones (Hormone)IBA 04/01/2001 - "[Human gonadotrophic hormone (HCG) in benign breast cyst fluid. " 01/01/1992 - "The fluid filling the cysts (breast cyst fluid, BCF) contains unusual amounts of biologically active substances, including hormones and metabolites. " 07/01/1990 - "In 66.7% of the breast cyst fluids examined the hormone levels were higher than normal serum values. " 11/01/1979 - "Accumulation of hormones in breast cyst fluid." 12/15/1977 - "Radioimmunoassay of some hormones simultaneously measured in serum and breast cyst fluid."

Therapies and Procedures

1.	Therapeutics 11/01/2002 - "To evaluate whether adjuvant pharmacologic therapy is effective in breast cysts recurrence prevention. " 11/01/2002 - "[Adjuvant pharmacologic therapy after fine needle aspiration of breast cysts in women]." 11/01/1989 - "Ultrasound assessment response to therapy of clinically undetected breast cysts." 09/01/1985 - "[Breast cysts--diagnosis and therapy]." 03/01/1998 - "We report two cases of spontaneous regression of breast cysts after Tamoxifen therapy for premenopausal breast cancer in the contralateral breast."
2.	Contraception (Birth Control) 05/01/1995 - " In addition to being a very safe method of birth control which is highly effective when taken correctly and consistently, birth control pill use protects women against ovarian cancer, endometrial cancer, painful or irregular periods, breast cysts, iron deficiency anemia, ectopic or tubal pregnancy, and infections of the fallopian tube requiring hospitalization. "
3.	Punctures 10/03/1981 - "The authors present a study of 631 breast-cyst punctures. " 04/01/1998 - "The clinical examination reveals a breast cyst containing a blood fluid which persists after the puncture. " 01/01/1991 - "Treatment of benign breast cysts represents a special problem--after puncture fluid builds up again very often after a short while. " 05/01/1985 - "Needle puncture followed by pneumocystography of palpable breast cysts. " 01/01/1985 - "Diagnosis of breast cysts with mammography, ultrasound and puncture. "
4.	Prosthesis Implantation 05/01/2006 - "This study was to investigate an operation, in which removing breast cysts of foreign body resulted from augmentation with polyacrylamide hydrogel injection was performed simultaneously with silicone prosthesis implantation under SEPS endoscope in order to relieve tissue injury and increase the accuracy of clearance. "
5.	Endoscopes 05/01/2006 - "This study was to investigate an operation, in which removing breast cysts of foreign body resulted from augmentation with polyacrylamide hydrogel injection was performed simultaneously with silicone prosthesis implantation under SEPS endoscope in order to relieve tissue injury and increase the accuracy of clearance. "