Breast Cyst

A fluid-filled closed cavity or sac that is lined by an EPITHELIUM and found in the BREAST. It may appear as a single large cyst in one breast, multifocal, or bilateral in FIBROCYSTIC BREAST DISEASE.

Also Known As:

Networked: 215 relevant articles (4 outcomes, 30 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cysts
2.	Breast Neoplasms (Breast Cancer)
3.	Fibrocystic Breast Disease (Chronic Cystic Mastitis)
4.	Necrosis
5.	Foreign Bodies (Foreign Body)

Experts

1.	Mannello, Ferdinando: 3 articles (06/2014 - 05/2006)
2.	Erten, Oya: 2 articles (02/2008 - 12/2007)
3.	Erbas, Hakan: 2 articles (02/2008 - 12/2007)
4.	Enriori, Pablo J: 2 articles (01/2006 - 02/2003)
5.	Lüthy, Isabel A: 2 articles (01/2006 - 02/2003)
6.	Etkin, Alberto E: 2 articles (01/2006 - 02/2003)
7.	Gori, Jorge R: 2 articles (01/2006 - 02/2003)
8.	Fischer, Carlos R: 2 articles (01/2006 - 02/2003)
9.	Calandra, Ricardo S: 2 articles (01/2006 - 02/2003)
10.	Wypych, Karol: 2 articles (11/2002 - 11/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Breast Cyst:

1.	Epidermal Growth Factor (EGF)IBA 11/01/1985 - "The mean concentration of EGF is significantly greater in breast cyst fluid (241 +/- 143 ng/ml) and in colostrum (197 +/- 56 ng/ml) than in milk (107 +/- 22 ng/ml). " 09/01/1991 - "[Epidermal growth factor behavior in breast cyst fluid. " 05/01/1990 - "Size-exclusion chromatography showed that breast cyst fluid from women at highest risk contained two peaks of growth factor activity: less than 6 kilodaltons (kd), identified as human EGF (epidermal growth factor), and 6 to 18 kd. " 04/01/1990 - "Breast cyst fluid concentrations of epidermal growth factor were significantly higher in the low electrolyte ratio group than in the high electrolyte ratio group (356.2 ng/ml vs 104.1 ng/ml, P less than 0.0003). " 01/01/1990 - "Epidermal growth factor in breast cyst fluids. "
2.	Proteins (Proteins, Gene)IBA 01/01/1992 - "Improved "electrophoretic map" of breast cyst fluid proteins." 01/01/1996 - "These proteins are normally found in benign breast cysts in vivo. " 10/31/1985 - "Platelet-associated proteins in human breast cyst fluids." 03/01/1977 - "A radioimmunoassay has been developed for one of the major proteins isolated from human breast cyst fluid. " 01/01/1986 - "Breast cyst fluid proteins and breast cancer."
3.	Danazol (Azol)FDA LinkGeneric 09/01/1986 - "A controlled trial of danazol in the treatment of multiple recurrent breast cysts." 11/01/1989 - "Long-term follow up of patients treated with a single course of danazol for recurrent breast cysts." 11/01/1988 - "An insufficient number of patients presented with breast cysts to draw any conclusions regarding the efficacy of danazol on cysts. "
4.	CholesterolIBA 04/01/2002 - "In order to establish an improved method for assaying dehydroepiandrosterone sulfate (DHEAS) and cholesterol, which are the largest components of human breast cyst and duct fluids, we describe a simple, accurate, and sensitive method using high-performance liquid chromatography (HPLC). " 12/01/1994 - "The levels of total cholesterol and HDL-C were found to be significantly higher, and the levels of triglycerides and VLDL-C significantly lower in breast cyst fluid compared to serum. " 05/01/1992 - "The absence of a correlation between cholesterol concentration and apo D concentration and the results from previous binding analysis suggest that this protein is not involved in the accumulation of cholesterol in breast-cyst fluid." 04/01/2002 - "Levels of free cholesterol, DHEAS, and DHEA in human breast cyst fluids (n = 30) were 1.77 +/- 1.12 mmol/dl, 8.27 +/- 10.24 micromol/dl, and 0.02 +/- 0.02 micromol/dl (means +/- SD), respectively. " 12/01/1994 - "The study entailed measuring total cholesterol, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), very low-density lipoprotein-cholesterol (VLDL-C) and triglyceride levels in the serum of 50 women with fibrocystic breast disease without macrocysts, and in the serum and breast cyst fluid of 60 women with fibrocystic breast disease and macrocysts. "
5.	Dehydroepiandrosterone SulfateIBA 04/01/2002 - "A simple, accurate, and sensitive assay method of dehydroepiandrosterone sulfate: application for quantitative determination in human breast cyst and duct fluids." 07/01/1995 - "No relationship between mammographic patterns and characteristics of breast cyst fluid such as K+/Na+ ratio, apocrine changes and dehydroepiandrosterone sulfate concentration was observed. " 04/01/2002 - "In order to establish an improved method for assaying dehydroepiandrosterone sulfate (DHEAS) and cholesterol, which are the largest components of human breast cyst and duct fluids, we describe a simple, accurate, and sensitive method using high-performance liquid chromatography (HPLC). " 11/01/1982 - "Dehydroepiandrosterone sulfate (DHAS) has been measured by radioimmunoassay in 100 breast cyst fluids obtained from 82 women. " 08/01/1987 - "Breast cyst fluid is rich in androgens, particularly dehydroepiandrosterone sulfate; concentrations of polypeptide hormones like FSH, LH, TSH, PRL, and calcitonin are invariably present sometimes in less and at other times in greater amounts than that found in plasma. "
6.	Transforming Growth Factor beta (TGF-beta)IBA 07/01/1999 - "The aim of the present study was to characterise the latent forms of TGF-beta 2 in breast cyst fluid using HPLC, affinity chromatography, SDS-PAGE and immunostaining techniques. " 07/01/1999 - "Latent forms of transforming growth factor-beta 2 (TGF-beta 2) in breast cyst fluid." 12/20/1996 - "No difference was found in transforming-growth factor-beta 1 (TGF-beta1) levels between the two sub-groups of breast cysts. " 04/01/2000 - "The TGF-beta 2 isoform has been shown to be present in high concentrations in breast cyst fluid and might have a protective role in breast cancer. " 07/01/1999 - "Women who have palpable breast cyst with intracystic Na/K < 3 may have a higher risk of developing breast cancer than those with intracystic Na/K > 3. Finding of significantly higher concentrations of TGF-beta 2 in the Na/K > 3 group than Na/K < 3 group may explain the lower risk of breast cancer in the Na/K > 3 group. "
7.	HormonesIBA 11/30/1990 - "Breast cysts fluid contains steroid but not studies have been reported on the ability of breast microcysts to metabolise steroid hormones. " 01/01/2006 - "Hormone and growth factor concentration levels were measured in breast cyst fluid (BCF) to correlate them with their mitogenic activity in tumour (MCF-7) or nontransformed (MCF-10A) cells. " 01/01/2006 - "Breast cyst fluids increase the proliferation of breast cell lines in correlation with their hormone and growth factor concentration." 07/01/2002 - "Breast cyst fluid contains various steroid hormones. " 07/01/2001 - "The breast cyst fluid contains unusual amounts of low- and high- molecular substances, including steroid hormones and their conjugates. "
8.	SodiumIBA 03/29/1997 - "Type of breast cyst based on cationic content of cyst fluid: type I (potassium:sodium ratio > 1.5), type II (potassium:sodium ratio < 1.5), or mixed (both types). " 10/21/1993 - "There are 2 main groups of breast cysts characterized by their intracystic sodium-to-potassium ratios. " 07/01/1988 - "The sodium (Na) and potassium (K) concentrations were measured in the fluid of 169 breast cysts aspirated from 101 consecutive patients presenting to a single clinic. " 03/01/1985 - "Correlation of concentrations of estriol-3-sulfate with those of potassium and sodium in human breast cyst fluid." 02/01/2005 - "We determined the biochemical composition of fluid aspirated from 52 breast cysts and classified the cysts into types I and II on the basis of the potassium-to-sodium (K/Na) ratio in the fluid. "
9.	PotassiumIBA 03/29/1997 - "Type of breast cyst based on cationic content of cyst fluid: type I (potassium:sodium ratio > 1.5), type II (potassium:sodium ratio < 1.5), or mixed (both types). " 10/21/1993 - "There are 2 main groups of breast cysts characterized by their intracystic sodium-to-potassium ratios. " 07/01/1988 - "The sodium (Na) and potassium (K) concentrations were measured in the fluid of 169 breast cysts aspirated from 101 consecutive patients presenting to a single clinic. " 03/01/1985 - "Correlation of concentrations of estriol-3-sulfate with those of potassium and sodium in human breast cyst fluid." 02/01/2005 - "We determined the biochemical composition of fluid aspirated from 52 breast cysts and classified the cysts into types I and II on the basis of the potassium-to-sodium (K/Na) ratio in the fluid. "
10.	Dehydroepiandrosterone (DHEA)IBA 01/01/1995 - "The aim of this study was to investigate whether breast cysts were capable of metabolizing radiolabeled dehydroepiandrosterone sulphate and, if so, to identify the metabolites formed. " 09/01/1988 - "We assayed Type 1 (high K+) and Type 2 (high Na+) human breast cyst fluids for DHEA-S. " 01/01/1995 - "Metabolism of dehydroepiandrosterone sulphate by breast cysts: possible role in the development of breast cancer." 09/01/1989 - "Relationship between epidermal growth factor and dehydroepiandrosterone and its sulphate in breast cyst fluid." 08/15/1989 - "Epidermal growth factor (EGF), dehydroepiandrosterone (DHA)-sulphate and [Na+] and [K+] were assayed in 78 cyst fluids from patients with a palpable breast cyst. "

Therapies and Procedures

1.	Prosthesis Implantation 05/01/2006 - "This study was to investigate an operation, in which removing breast cysts of foreign body resulted from augmentation with polyacrylamide hydrogel injection was performed simultaneously with silicone prosthesis implantation under SEPS endoscope in order to relieve tissue injury and increase the accuracy of clearance. "
2.	Endoscopes 05/01/2006 - "This study was to investigate an operation, in which removing breast cysts of foreign body resulted from augmentation with polyacrylamide hydrogel injection was performed simultaneously with silicone prosthesis implantation under SEPS endoscope in order to relieve tissue injury and increase the accuracy of clearance. "
3.	Cardiopulmonary Bypass (Heart-Lung Bypass) 10/01/2015 - "After one week of albendazole treatment, surgical excision of the cardiac cyst on cardiopulmonary bypass was carried out as well as excision of the pulmonary and breast cysts. "