Estrogen Receptor beta

One of the ESTROGEN RECEPTORS that has greater affinity for ISOFLAVONES than ESTROGEN RECEPTOR ALPHA does. There is great sequence homology with ER alpha in the DNA-binding domain but not in the ligand binding and hinge domains.

Also Known As:

Networked: 1043 relevant articles (16 outcomes, 170 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gustafsson, Jan-Ake: 58 articles (01/2014 - 01/2002)
2.	Warner, Margaret: 19 articles (05/2010 - 06/2002)
3.	Gustafsson, J A: 15 articles (12/2008 - 02/2000)
4.	Dahlman-Wright, Karin: 12 articles (01/2014 - 06/2003)
5.	Sasano, Hironobu: 11 articles (05/2013 - 03/2004)
6.	Ho, Shuk-Mei: 10 articles (08/2013 - 10/2003)
7.	Suzuki, Takashi: 10 articles (05/2013 - 03/2004)
8.	Zhao, Chunyan: 9 articles (01/2014 - 06/2003)
9.	Harris, Heather A: 9 articles (04/2010 - 10/2003)
10.	Ström, Anders: 9 articles (01/2010 - 02/2004)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2014 - "This study is to determine the expression of estrogen receptor beta (ERβ) in breast cancer patients and to evaluate its relationship with clinicopathological parameters of breast cancer and its effects on the prognosis of breast cancer patients. " 05/09/2013 - "ERbeta (ERβ) inhibits growth in vitro; its effects in vivo have been incompletely investigated and its role in breast cancer and potential as alternative target in endocrine therapy needs further study. " 06/15/2010 - "In this study, we applied the ChIP-on-chip approach to identify ERbeta-binding sites on a genome-wide scale, identifying 1,457 high-confidence binding sites in ERbeta-overexpressing MCF7 breast cancer cells. " 02/01/2010 - "Estrogen receptor-beta expression in invasive breast cancer in relation to molecular phenotype: results from the Nurses' Health Study." 08/01/2009 - "In summary, experimental, epidemiological as well as diagnostic studies point towards ERbeta as an important factor in breast cancer, opening up the possibility for novel ERbeta-selective therapies in the treatment of breast cancer."
2.	Inflammation 01/01/2010 - "As seen in the AA model, the selective ERbeta agonist ERB-79 did not suppress inflammation. " 07/01/2008 - "In these modeling systems of airway inflammation, an ERbeta agonist was ineffective. " 01/01/2008 - "In fact, selective ERbeta agonists have beneficial effects in preclinical models involving inflammation without causing growth-promoting effects on the uterus or mammary gland. " 12/28/2006 - "Clinical trials for these diseases are underway: however, the role of estrogen receptor-beta in modulating pain associated with inflammation remains unknown. " 04/01/2009 - "The expression of ERbeta is reduced with increased scores on the inflammation of the prostate tissues in BPH patients, and the decreased ERbeta expression may be associated with the inflammatory stimulation of prostatitis."
3.	Obesity 02/20/2009 - "Few studies have examined the association between genetic variants of the estrogen receptor beta (ESR2) and obesity in postmenopausal women. " 02/20/2009 - "Association of estrogen receptor 2 gene polymorphisms with obesity in women (obesity and estrogen receptor 2 gene)." 01/01/2015 - "Obesity is associated with a worse breast cancer prognosis, while greater breast tumor estrogen receptor beta (ERβ) expression is correlated with improved therapy response and survival. " 01/01/2015 - "Obesity Suppresses Estrogen Receptor Beta Expression in Breast Cancer Cells via a HER2-Mediated Pathway." 12/01/2011 - "In age-adjusted models, there were positive associations between higher BPA concentrations and higher ESR2 [estrogen receptor 2 (ER beta)] expression (unstandardized linear regression coefficient = 0.1804; 95% CI: 0.0388, 0.3221; p = 0.013) and ESRRA (estrogen related receptor alpha) expression (coefficient = 0.1718; 95% CI: 0.0213, 0.3223; p = 0.026): These associations were little changed after adjusting for potential confounders, including obesity, serum lipid concentrations, and white cell subtype percentages. "
4.	Prostatic Neoplasms (Prostate Cancer) 03/01/2011 - "In the present study, we have addressed the question whether these coactivators enhance activity of estrogen receptor-beta (ER-β), which is variably expressed in prostate cancers. " 06/01/2009 - "In concert with recent studies the findings suggest differential production of ERbeta splice variants, which may play important roles in the genesis of prostate cancer." 02/01/2003 - "Using a new monoclonal antibody, the current study reports on the differential expression of the ERbeta in tissue sections from 132 patients with prostate cancer. " 08/01/2014 - "Estrogen receptor beta in prostate cancer: friend or foe?" 09/01/2013 - "Although estrogen receptor beta (ERβ) has been implicated in prostate cancer (PCa) progression, its potential role in health disparity of PCa remains elusive. "
5.	Carcinoma (Carcinomatosis) 07/01/2006 - "ERbeta may be a useful marker of ovarian carcinogenesis and could predict the efficacy of endocrinotherapy and the prognosis for patients with ovarian carcinoma." 07/01/2004 - "Initial studies have shown that ERbeta expression declines in breast, ovarian, prostatic, and colon carcinomas. " 10/15/2001 - "The results of the current study demonstrate, for what we believe to be the first time, that the inactivation of the ERbeta gene in prostate carcinoma occurs through CpG methylation of the promoter region of this gene." 12/01/2012 - "Estrogen receptor beta (ERβ) and TROP2 expressed in colon carcinoma and might play an important role there. " 04/13/2010 - "We report that a key function of ERbeta and its specific ligand 5alpha-androstane-3beta,17beta-diol (3beta-adiol) is to maintain an epithelial phenotype and repress mesenchymal characteristics in prostate carcinoma. "

Related Drugs and Biologics

1.	Estrogens (Estrogen)
2.	Estrogen Receptor alpha
3.	Estrogen Receptor beta
4.	Messenger RNA (mRNA)
5.	Estrogen Receptors
6.	Protein Isoforms (Isoforms)
7.	Estradiol (Estrace)
8.	Phytoestrogens (Phytoestrogen)
9.	Estrogen Receptor Modulators (Antiestrogen)
10.	Peroxidase (Myeloperoxidase)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Ovariectomy (Oophorectomy)
3.	Lasers (Laser)
4.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
5.	Mammaplasty (Breast Reconstruction)