Massive Hepatic Necrosis

Extensive and rapid death of parenchymal cells in the LIVER, often due to exposure to toxic materials. It is characterized by a soft, flabby, yellow-brown wrinkled, and shrunken liver. It was called "acute yellow atrophy".

Also Known As:

Networked: 109 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hepatitis
2.	Liver Cirrhosis (Hepatic Cirrhosis)
3.	Protein Deficiency
4.	Melanoma (Melanoma, Malignant)
5.	Hepatic Encephalopathy

Experts

1.	Da Ines, David: 2 articles (05/2013 - 08/2010)
2.	Buc, Emmanuel: 2 articles (05/2013 - 08/2010)
3.	Chen, Chih-Chiun: 1 article (05/2015)
4.	Kim, Ki-Hyun: 1 article (05/2015)
5.	Lau, Lester F: 1 article (05/2015)
6.	Alpini, Gianfranco: 1 article (05/2015)
7.	Dupré, Aurélien: 1 article (05/2013)
8.	Tixier, Lucie: 1 article (05/2013)
9.	Gagnière, Johan: 1 article (05/2013)
10.	Perbet, Sébastien: 1 article (05/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Massive Hepatic Necrosis:

1.	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 08/01/2000 - "Our findings suggested that monitoring the soluble TNF receptor-I level may help to assess the prognosis of acute-type fulminant hepatitis and that TNF might be associated with massive hepatic necrosis."
2.	Proteins (Proteins, Gene)IBA 11/01/1993 - "Protective effects of FUT-175 on acute massive hepatic necrosis induced in mice following endotoxin injection and immunization with liver proteins."
3.	nafamostatIBA 11/01/1993 - "Protective effects of FUT-175 on acute massive hepatic necrosis induced in mice following endotoxin injection and immunization with liver proteins."
4.	TransaminasesIBA 04/01/2012 - "CCl(4) intoxication resulted in a massive hepatic necrosis and increased plasma transaminases. " 05/01/2002 - "At this time, liver injury was induced, accompanied by massive hepatic necrosis and the elevation of transaminases. " 07/01/1983 - "The intrabiliary administration of the ethanolamine oleate resulted in massive liver injury with 85,9% of hepatic coma during the first 96 hr. The liver damage was characterized by clinical manifestations (anorexia, increasing stupor, muscle wasting and deep coma), serum biochemical tests (elevations of serum transaminases, bilirubins , alkaline phosphatase), studies of blood coagulation (prothrombin and partial thromboplastin times were markedly prolonged and the concentration of fibrinogen decreased) and histopathological findings (massive hepatic necrosis). "
5.	Dacarbazine (DIC)FDA LinkGeneric 05/15/1988 - "A fatal massive hepatic necrosis with widespread thrombotic occlusion of the small hepatic veins developed in two of 68 patients treated with DTIC for advanced melanoma in a randomized study. " 11/01/1976 - "After an acute terminal illness that was characterized by fulminant hepatic failure and disseminated intravascular coagulation (DIC), postmortem examination disclosed massive hepatic necrosis. "
6.	Thromboplastin (Tissue Factor)IBA 07/01/1983 - "The intrabiliary administration of the ethanolamine oleate resulted in massive liver injury with 85,9% of hepatic coma during the first 96 hr. The liver damage was characterized by clinical manifestations (anorexia, increasing stupor, muscle wasting and deep coma), serum biochemical tests (elevations of serum transaminases, bilirubins , alkaline phosphatase), studies of blood coagulation (prothrombin and partial thromboplastin times were markedly prolonged and the concentration of fibrinogen decreased) and histopathological findings (massive hepatic necrosis). "
7.	Prothrombin (Factor II)IBA 07/01/1983 - "The intrabiliary administration of the ethanolamine oleate resulted in massive liver injury with 85,9% of hepatic coma during the first 96 hr. The liver damage was characterized by clinical manifestations (anorexia, increasing stupor, muscle wasting and deep coma), serum biochemical tests (elevations of serum transaminases, bilirubins , alkaline phosphatase), studies of blood coagulation (prothrombin and partial thromboplastin times were markedly prolonged and the concentration of fibrinogen decreased) and histopathological findings (massive hepatic necrosis). "
8.	Lipotropic Agents (Lipotropics)IBA 02/15/1953 - "[Serologic and electrophoretic studies of the course of liver cirrhosis and acute yellow atrophy of the liver treated with lipotropics, with special reference to pathogenetic protein deficiency damage]."
9.	Fibrinogen (Factor I)FDA Link 07/01/1983 - "The intrabiliary administration of the ethanolamine oleate resulted in massive liver injury with 85,9% of hepatic coma during the first 96 hr. The liver damage was characterized by clinical manifestations (anorexia, increasing stupor, muscle wasting and deep coma), serum biochemical tests (elevations of serum transaminases, bilirubins , alkaline phosphatase), studies of blood coagulation (prothrombin and partial thromboplastin times were markedly prolonged and the concentration of fibrinogen decreased) and histopathological findings (massive hepatic necrosis). "
10.	Alkaline PhosphataseIBA 07/01/1983 - "The intrabiliary administration of the ethanolamine oleate resulted in massive liver injury with 85,9% of hepatic coma during the first 96 hr. The liver damage was characterized by clinical manifestations (anorexia, increasing stupor, muscle wasting and deep coma), serum biochemical tests (elevations of serum transaminases, bilirubins , alkaline phosphatase), studies of blood coagulation (prothrombin and partial thromboplastin times were markedly prolonged and the concentration of fibrinogen decreased) and histopathological findings (massive hepatic necrosis). "

Therapies and Procedures

1.	Plasmapheresis 06/01/1970 - "[Acute yellow atrophy in pregnancy (acute spongiocytic steatosis in pregnancy): a case treated by plasmapheresis and studied with the electron microscope]." 08/01/1989 - "The combination of twice daily plasmapheresis and intensive conservative therapy was effective for these pediatric patients with fulminant hepatitis, except those with massive hepatic necrosis."
2.	Ligation 05/14/2013 - "Massive hepatic necrosis with toxic liver syndrome following portal vein ligation." 05/01/2015 - "Knock-in mice expressing a CCN1 mutant that is unable to bind αvβ5/αvβ3 were impaired in ductular reaction, leading to massive hepatic necrosis and mortality after bile duct ligation (BDL), whereas treatment of these mice with soluble JAG1 rescued ductular reaction and reduced hepatic necrosis and mortality. " 12/01/1999 - "At one week, after massive hepatic necrosis following ligation, the livers were restored to their normal architecture without causing post-necrotic fibrosis. "
3.	Hepatectomy 09/01/1990 - "Provocation of massive hepatic necrosis by endotoxin after partial hepatectomy in rats." 08/01/1998 - "Liver failure following major hepatectomy is characterized pathologically by massive hepatic necrosis, which is thought to begin with injury of sinusoidal endothelial cells (SECs). " 02/01/1992 - "It is thought that regeneration of the liver provides a state of preparedness for the Shwartzman reaction and contributes to the development of endotoxin-associated massive hepatic necrosis following partial hepatectomy. "
4.	Drug Therapy (Chemotherapy) 07/01/1985 - "Massive hepatic necrosis after chemotherapy withdrawal in a hepatitis B virus carrier." 07/05/1954 - "[Acute yellow atrophy of the liver during chemotherapy with report of three cases]." 07/01/1985 - "A chronic hepatitis B virus (HBV) carrier with diffuse nodular transformation of the liver and malignant lymphoma in the lymph nodes and spleen developed massive hepatic necrosis and died three weeks after the third cycle of chemotherapy. " 12/01/2003 - "Reactivation of hepatitis B in patients receiving chemotherapy for acute leukemia may give rise to a variety of clinical patterns including hepatitis, asymtomatic hepatic dysfunction, massive hepatic necrosis and fatal hepatic failure. "
5.	Anesthesia 03/09/1972 - "Massive hepatic necrosis after fluroxene anesthesia--a case of drug interaction?" 04/11/1964 - "MASSIVE HEPATIC NECROSIS ASSOCIATED WITH HALOTHANE ANESTHESIA." 01/01/1963 - "Halothane anesthesia as a possible cause of massive hepatic necrosis."