Retinoid X Receptors (Retinoid X Receptor)

A subtype of RETINOIC ACID RECEPTORS that are specific for 9-cis-retinoic acid which function as nuclear TRANSCRIPTION FACTORS that regulate multiple signaling pathways.

Also Known As:

Retinoid X Receptor; 9-cis-Retinoic Acid Receptor; RXR Protein; Receptor, Retinoid X; XR78E-F protein; Protein, RXR; Receptor, 9-cis-Retinoic Acid; Receptors, Retinoid X; XR78E F protein; protein, XR78E-F

Networked: 606 relevant articles (19 outcomes, 55 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Retinoic Acid Receptors: 1114
      - Retinoid X Receptors: 606
  - Cytoplasmic and Nuclear Receptors: 3987
    - Retinoic Acid Receptors: 1114
      - Retinoid X Receptors: 606
        Retinoid X Receptor alpha: 119
        Retinoid X Receptor gamma: 16
        Retinoid X Receptor beta: 11

Experts

1.	Kakuta, Hiroki: 22 articles (01/2022 - 03/2008)
2.	Makishima, Makoto: 12 articles (01/2021 - 03/2008)
3.	Shimizu, Masahito: 11 articles (01/2022 - 03/2007)
4.	Moriwaki, Hisataka: 11 articles (01/2014 - 02/2002)
5.	Yamada, Shoya: 10 articles (01/2021 - 09/2010)
6.	Muccio, Donald D: 10 articles (01/2020 - 08/2003)
7.	Grubbs, Clinton J: 10 articles (06/2018 - 08/2003)
8.	Watanabe, Masaki: 8 articles (01/2022 - 01/2017)
9.	Atigadda, Venkatram R: 8 articles (01/2020 - 08/2003)
10.	Tai, Akihiro: 8 articles (03/2013 - 03/2008)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2023 - "Retinoid X Receptor agonists as selective modulators of the immune system for the treatment of cancer." 01/01/2022 - "It affects the nuclear retinoid-X-receptor (RXR), which implies a modulating effect of RXR to gynaecologic cancers. " 11/01/2019 - "The retinoid X receptor (RXR) has a role in regulating cell cycle, differentiation and apoptosis, and agonism of RXR has been investigated as a treatment strategy in several types of cancer. " 01/01/2017 - "This review focuses on our efforts to translate a low-toxicity retinoid X receptor-selective agonist, UAB30, to the clinic for the prevention of breast cancers. " 03/01/2016 - "Abnormal expression of Retinoid X Receptor α (RXRα) seems to be a frequent incident in a variety of cancers. "
2.	Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous) 06/01/2018 - "The retinoid X receptor agonist, 9-cis UAB30, inhibits cutaneous T-cell lymphoma proliferation through the SKP2-p27kip1 axis." 02/01/2006 - "Retinoid X receptor-specific rexinoids have also shown efficacy in the treatment of cutaneous T-cell lymphomas, but their exact mechanism of action is unclear. " 02/01/2017 - "Phase I/II study of the oral retinoid X receptor agonist bexarotene in Japanese patients with cutaneous T-cell lymphomas." 11/04/2023 - "Bexarotene, a drug approved for treatment of cutaneous T-cell lymphoma (CTCL), is classified as a rexinoid by its ability to act as a retinoid X receptor (RXR) agonist with high specificity. " 01/01/2023 - "Bexarotene, a retinoid X receptor (RXR) agonist, is approved by FDA to treat cutaneous T-cell lymphoma. "
3.	Carcinoma (Carcinomatosis) 06/01/2018 - "Expression and clinical significance of retinoid X receptor α in esophageal carcinoma." 06/01/2018 - "Esophageal carcinoma (EC) is one of the most aggressive type cancers and dysregulation of retinoid X receptor α (RXRα) involves various tumors. " 10/26/2015 - "Notably, the expression of retinoic acid receptor (RAR-β) and retinoid X receptors (RXR-β, -γ) was significantly upregulated in sebaceous cell carcinoma of the eyelids. " 10/01/2010 - "Differential expression and cross-talk of peroxisome proliferator-activated receptor γ and retinoid-X receptor α in urothelial carcinomas of the bladder." 10/09/1998 - "Overexpressed activated retinoid X receptors can mediate growth inhibitory effects of retinoids in human carcinoma cells."
4.	Breast Neoplasms (Breast Cancer) 01/01/2023 - "FOXA1 Reprogramming Dictates Retinoid X Receptor Response in ESR1-Mutant Breast Cancer." 01/01/2006 - "It should be emphasized that most breast carcinomas and breast cancer cell lines show loss or down-regulation of RARbeta receptor expression, whereas RARalpha and gamma, as well as retinoid X receptors, appear to be variably expressed in both normal and tumour cells. " 11/01/2015 - "Retinoid X receptor α (RXRα) plays important roles in the malignancy of several cancers such as human prostate tumor, breast cancer, and thyroid tumor. " 01/01/1998 - "A high-risk lesion for invasive breast cancer, ductal carcinoma in situ, exhibits frequent overexpression of retinoid X receptor." 06/01/2006 - "A number of retinoid X receptor (RXR) agonists have proven to be highly effective in preventing methylnitrosourea (MNU) induced mammary cancers. "
5.	Alzheimer Disease (Alzheimer's Disease) 01/01/2021 - "Retinoid X receptor activation promotes re-myelination in a very old triple transgenic mouse model of Alzheimer's disease." 09/05/2015 - "Small molecule TBTC as a new selective retinoid X receptor α agonist improves behavioral deficit in Alzheimer's disease model mice." 01/01/2014 - "Potential retinoid x receptor agonists for treating Alzheimer's disease from traditional chinese medicine." 01/01/2021 - "Retinoid X receptor (RXR) modulators (rexinoids) are considered to have therapeutic potential for multiple diseases, such as Alzheimer's disease and Parkinson's disease. " 12/01/2021 - "Role of Retinoid X Receptors (RXRs) and dietary vitamin A in Alzheimer's disease: Evidence from clinicopathological and preclinical studies."

Related Drugs and Biologics

1.	Bexarotene (LGD1069)
2.	Ligands
3.	Retinoids
4.	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)
5.	PPAR gamma
6.	Methylnitrosourea (N-Methyl-N-nitrosourea)
7.	Peroxisome Proliferator-Activated Receptors (PPAR)
8.	Apolipoproteins
9.	Liver X Receptors
10.	Tretinoin (Retinoic Acid)

Related Therapies and Procedures

1.	Therapeutics
2.	Chemoprevention
3.	Drug Therapy (Chemotherapy)
4.	Glycemic Control
5.	Intraperitoneal Injections