Casein Kinases (Casein Kinase)

A group of protein-serine-threonine kinases that was originally identified as being responsible for the PHOSPHORYLATION of CASEINS. They are ubiquitous enzymes that have a preference for acidic proteins. Casein kinases play a role in SIGNAL TRANSDUCTION by phosphorylating a variety of regulatory cytoplasmic and regulatory nuclear proteins.

Also Known As:

Networked: 99 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Tibbetts, Randal S: 4 articles (08/2013 - 03/2007)
2.	Kim, Sang Hwa: 3 articles (08/2013 - 01/2010)
3.	Shanware, Naval P: 3 articles (04/2011 - 03/2007)
4.	Trinh, Anthony T: 2 articles (08/2013 - 03/2007)
5.	Kim, Kunhong: 2 articles (08/2012 - 08/2012)
6.	Yook, Jong In: 2 articles (08/2012 - 08/2012)
7.	Zhan, Lihong: 2 articles (04/2011 - 01/2010)
8.	Hutchinson, John A: 2 articles (04/2011 - 01/2010)
9.	Williams, Leah M: 2 articles (01/2010 - 03/2007)
10.	Meijer, Laurent: 2 articles (09/2008 - 11/2006)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2014 - "Recent studies have indicated that casein kinase 1-epsilon (CK1ε) and casein kinase 1-delta (CK1δ) expression has a role in human cancers. " 04/01/2015 - "Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers." 07/01/2014 - "Protein casein kinase 2-alpha (CK2α) has been indicated to participate in the pathogenesis of this cancer; however, the underlying mechanisms still need to be elucidated. " 01/01/2008 - "Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest." 03/28/2003 - "Two gene products reported to function in Wingless (Wg) signaling were identified as Hh pathway components: a cell surface protein (Dally-like protein) required for Hh signal reception, and casein kinase 1alpha, a candidate tumor suppressor that regulates basal activities of both Hh and Wg pathways. "
2.	Carcinoma (Carcinomatosis) 10/01/2012 - "To investigate the expression of casein kinase 2β in esophageal carcinoma tissues and analyze its clinical significance. " 10/01/2012 - "[Effect of casein kinase 2β in esophageal carcinoma and its clinical significance]." 01/01/1986 - "Casein kinase type II were isolated by the same procedure, from rat liver, human placenta, Querin carcinoma and yeast, and characterized. " 11/01/1983 - "The existence of a high and low molecular weight forms of casein kinase (Mr = 180 000 and 32 000, respectively) in Ehrlich ascite carcinoma cell cytosol was demonstrated." 05/01/2012 - "The aim of this study was to explore the effect of siRNA specific to the protein casein kinase 2α (CK2α) on apoptosis of laryngeal carcinoma cells and to explore possible mechanisms. "
3.	Ataxia Telangiectasia (Louis Bar Syndrome) 08/16/2013 - "The KID also contains a highly conserved phosphorylation cluster, termed the ATM/CK cluster, which is processively phosphorylated in response to DNA damage by the coordinated actions of ataxia-telangiectasia-mutated (ATM) and casein kinases (CKs) 1 and 2. The ATM/CK cluster phosphorylation attenuates CBP binding and CREB transcriptional activity. " 03/02/2007 - "Coregulated ataxia telangiectasia-mutated and casein kinase sites modulate cAMP-response element-binding protein-coactivator interactions in response to DNA damage." 01/01/2010 - "Previous studies demonstrated that CREB is phosphorylated on a cluster of conserved Ser residues, including Ser-111 and Ser-121, in response to DNA damage through the coordinated actions of the ataxia-telangiectasia-mutated (ATM) protein kinase and casein kinases 1 and 2 (CK1/2). "
4.	Experimental Liver Neoplasms 11/01/1985 - "The purpose of this study was to compare the sites that are phosphorylated in vitro by casein kinase type II with the site(s) phosphorylated in vivo in rapidly growing Novikoff hepatoma cells. "
5.	AIDS-Related Complex (ARC) 08/01/2013 - "Sensitization study has been carried out to check the role of endogenous ARC using casein-kinase inhibitors. "

Related Drugs and Biologics

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4.	Protein Kinases (Protein Kinase)
5.	Glycogen Synthase Kinases
6.	Cyclins
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8.	Cyclin-Dependent Kinases (cdk Proteins)
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