Luteolin

10/01/2010 - "Therefore, luteolin consumption may be beneficial in preventing or treating conditions involving increased microglial cell activity and inflammation."
11/01/2008 - "In vivo, luteolin reduced increased vascular permeability and was effective in animal models of inflammation after parenteral and oral application. "
01/01/2014 - "The present study was designed to test whether luteolin inhibits TNF-α-induced inflammation and oxidative stress in human umbilical vein endothelial cells(HUVECs) and identify some of the mechanisms underlying these effects. "
09/01/2013 - "In this study, we investigated whether luteolin inhibits gut inflammation, using in vivo and in vitro inflammation models. "
03/01/2015 - "In conclusion, luteolin protects against TNF-α-induced vascular inflammation in both in vitro and in vivo models. "

01/01/2014 - "Here, we evaluated the efficacy of luteolin as a VRK1-targeted inhibitor for developing an effective anti-cancer strategy. "
09/01/2005 - "Thus the chemopreventive efficacy of luteolin against colon carcinogenesis is evidenced by our preliminary studies which showed decreased incidence of tumors and the antiperoxidative and antioxidant effect of luteolin. "
01/01/2016 - "Despite extensive study of luteolin, the literature has no information on the exact mechanisms or molecular targets through which it deters cancer progression. "
01/01/2014 - "Therefore, our study suggests that luteolin-induced VRK1 inhibition may contribute to establish a novel cell cycle-targeted strategy for anti-cancer therapy. "
01/01/2013 - "The aim of this study was to evaluate the anti-cancer effect of Limoniastrum guyonianum aqueous gall extract (G extract) and luteolin in the human cervical cancer HeLa cell line, and, if so, to clarify the underlying mechanism. "

05/01/2015 - "Luteolin ameliorates the deleterious effects of diet-induced obesity and its comorbidity via the interplay between liver and adipose tissue. "
05/01/2015 - "The aim of the current study was to elucidate the action of luteolin on obesity and its comorbidity by analyzing its transcriptional and metabolic responses, in particular the luteolin-mediated cross-talk between liver and adipose tissue in diet-induced obese mice. "
05/01/2015 - "However, few studies exist on the in vivo mechanism underlying the actions of luteolin in hepatic steatosis and obesity. "
07/01/2014 - "Luteolin protects against high fat diet-induced cognitive deficits in obesity mice."
01/01/2015 - "Brain "fog," inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin."

01/01/2011 - "In addition, luteolin pretreatment significantly improved cardiomyocyte shortening amplitude, decreased the apoptotic rate, upregulated Bcl-2 expression, downregulated Bax expression and raised the Bcl-2/Bax ratio under a simulated ischemia/reperfusion (SI/R) condition. "
04/25/2011 - "[Protective effects of luteolin preconditioning on rat liver under ischemia/reperfusion]."
10/01/2011 - "Furthermore, luteolin at 10.0 μg/ml improved ischemia-reperfusion induced myocardial function, by improving heart rate, +dp/dt(max) and -dp/dt(max), and also limiting the decline of left ventricular systolic pressure (LVSP) and elevation of left ventricular end-diastolic pressure (LVEDP) to some extent. "
10/01/2014 - "The purpose of this study is to investigate the potential protective effect of the flavonoid Luteolin on ischemia-reperfusion (IR) injury in mouse intestine, which has not previously been studied. "
01/01/2013 - "Recent studies have suggested that administration of luteolin yields cardioprotective effects during ischemia/reperfusion (I/R) in rats. "

01/01/2015 - "In the present study, we found that luteolin has biphasic effects on the viability of the human breast cancer cell line MCF-7. "
01/01/2014 - "In this study, we prepared nano phytosomes of luteolin to enhance the bioavailability of luteolin and improve passive targeting in breast cancer cells. "
11/15/2013 - "The results of this study suggest that luteolin can be used as a chemosensitiser to target the expression level of CCNE2 and that it could be a novel strategy to overcome TAM resistance in breast cancer patients. "
11/01/2013 - "The present study was undertaken to investigate the inhibitory mechanism of cell invasion by luteolin 8-C-β-fucopyranoside (named as LU8C-FP), a C-glycosylflavone, in human breast cancer cells. "
10/25/2013 - "The purpose of the present study was to investigate the effect of luteolin on the angiogenesis and invasion of breast cancer cells. "