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Apigenin

5,7,4'-trihydroxy-flavone, one of the FLAVONES.
Also Known As:
5,7-dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone
Networked: 1098 relevant articles (126 outcomes, 323 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Gupta, Sanjay: 23 articles (12/2017 - 05/2002)
2. Shukla, Sanjeev: 17 articles (10/2015 - 02/2004)
3. Pelling, Jill C: 15 articles (05/2016 - 01/2002)
4. Doseff, Andrea I: 9 articles (01/2021 - 09/2006)
5. Fu, Pingfu: 8 articles (10/2015 - 12/2005)
6. Banik, Naren L: 8 articles (10/2013 - 12/2006)
7. Ray, Swapan K: 8 articles (10/2013 - 12/2006)
8. Xie, Mei-Lin: 6 articles (09/2021 - 06/2013)
9. Simopoulos, Constantinos: 6 articles (06/2021 - 07/2013)
10. Jiang, Bing-Hua: 6 articles (01/2019 - 03/2005)

Related Diseases

1. Neoplasms (Cancer)
2. Inflammation (Inflammations)
3. Insulin Resistance
05/19/2016 - "Apigenin Ameliorates Dyslipidemia, Hepatic Steatosis and Insulin Resistance by Modulating Metabolic and Transcriptional Profiles in the Liver of High-Fat Diet-Induced Obese Mice."
01/01/2021 - "This study highlights a new mechanism of apigenin and proposes that these hypolipidemic effects are associated with the mitigation of endoplasmic reticulum stress and insulin resistance in diet-induced obesity. "
02/01/2015 - "The apigenin-treated groups showed a significantly greater change in insulin sensitivity than the untreated model group,with the most significant change occurring in the high-dose grouP(P less than 0.05).Compared with the untreated model group,the apigenin-treated groups showed lower levels of ALT (95.4+/-7.3),AST (183.7+/-14.3),TC (1.61+/-0.25),TG (1.23+/-0.21),LDL-C (1.86+/-0.14),FBG (5.29+/-1.45) and FINS (0.76+/-0.86),but a higher level of HDL-C (1.04+/-0.17); again,the high-dose group showed the greatest change (all P less than 0.05).Compared to the untreated model group,the apigenin-treated groups showed significantly lower liver index (3.75+/-0.25 vs.2.90+/-0.17) and HOMA-IR (1.34+/-0.06 vs.0.18+/-0.04),with the high-dose group showing the greatest change (both P less than 0.05). "
07/02/2018 - "Based on the reduction of percentage of body fat and systolic pressure as well as the improvements in insulin resistance, lipid metabolism, and pathological injury to the thoracic aorta, we suggested that high levels of fructose cause vascular injury and metabolic disorders, which can be improved to some extent by using apigenin. "
05/19/2016 - "The anti-hyperglycemic effect of apigenin appeared to be related to decreased insulin resistance, hyperinsulinemia and hepatic gluconeogenic enzymes activities. "
4. Breast Neoplasms (Breast Cancer)
5. Carcinoma (Carcinomatosis)

Related Drugs and Biologics

1. Flavonoids
2. Luteolin
3. Quercetin
4. Phytochemicals
5. Antioxidants
6. kaempferol
7. Fluorouracil (Carac)
8. Liposomes (Liposome)
9. oxidized low density lipoprotein
10. Lipids

Related Therapies and Procedures

1. Therapeutics
2. Ligation
3. Punctures
4. Chemoprevention
5. Injections