Angiotensin II Type 1 Receptor Blockers

Agents that antagonize ANGIOTENSIN II TYPE 1 RECEPTOR. Included are ANGIOTENSIN II analogs such as SARALASIN and biphenylimidazoles such as LOSARTAN. Some are used as ANTIHYPERTENSIVE AGENTS.

Also Known As:

Angiotensin 2 Type 1 Receptor Antagonists; Angiotensin II Type 1 Receptor Antagonists; Sartans; Selective Angiotensin II Receptor Antagonists; Type 1 Angiotensin Receptor Antagonists; Type 1 Angiotensin Receptor Blockers; Angiotensin II Type 1 Receptor Antagonist; Angiotensin II Type 1 Receptor Blocker; Sartan

Networked: 725 relevant articles (50 outcomes, 124 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 164
  - Molecular Mechanisms of Pharmacological Action: 26
    - Angiotensin Receptor Antagonists: 6976
      - Angiotensin II Type 1 Receptor Blockers: 725

Experts

1.	Saku, Keijiro: 12 articles (01/2020 - 06/2003)
2.	Tchernev, G: 10 articles (11/2023 - 01/2023)
3.	Yoshiji, Hitoshi: 8 articles (01/2022 - 05/2009)
4.	Kaji, Kosuke: 7 articles (01/2022 - 05/2009)
5.	Kawaratani, Hideto: 7 articles (01/2022 - 05/2009)
6.	Namisaki, Tadashi: 7 articles (01/2022 - 05/2009)
7.	Kobori, Hiroyuki: 7 articles (03/2013 - 01/2006)
8.	Jeong, Myung Ho: 6 articles (07/2023 - 09/2013)
9.	Moriya, Kei: 6 articles (01/2022 - 02/2016)
10.	Noguchi, Ryuichi: 6 articles (01/2022 - 05/2009)

Related Diseases

1.	Heart Failure 09/01/2006 - "Although angiotensin II type 1 receptor blocker (ARB) has been demonstrated to be effective in the treatment of heart failure, information about the potential benefits of ARB on advanced LV failure associated with diabetes is lacking. " 09/01/2002 - "Angiotensin II type 1 receptor antagonist (AIIRA) has been reported to improve exercise capacity and prognosis in patients with congestive heart failure (CHF). " 02/25/2018 - "In the heart failure treated with intracerebroventricular (ICV) infusion of angiotensin II type 1 receptor blocker (ARB), sympathetic activation and brain oxidative stress were significantly lower, and baroreflex sensitivity and volume tolerance were significantly higher than in heart failure treated with vehicle. " 11/01/2007 - "Angiotensin II type 1 receptor blockers (ARBs) are used for controlling blood pressure and treating heart failure in a broad range of patients, including those with diabetes and the elderly. " 09/01/2002 - "Effects of chronic subdepressor dose of angiotensin II type 1 receptor antagonist on endothelium-dependent vasodilation in patients with congestive heart failure."
2.	Diabetic Nephropathies (Diabetic Nephropathy) 10/01/2002 - "CS-886, a new angiotensin II type 1 receptor antagonist, ameliorates glomerular anionic site loss and prevents progression of diabetic nephropathy in Otsuka Long-Evans Tokushima fatty rats." 11/01/2009 - "In this study, we examined whether the angiotensin II type 1 receptor blocker (ARB) would improve ambulatory short-term BP variability in hypertensive patients with diabetic nephropathy. " 06/01/2008 - "In this study, we examined whether urinary Smad1 in an early phase of diabetes can predict later development of glomerulosclerosis in diabetic nephropathy and how an angiotensin II type 1 receptor blocker (ARB) can modulate structural changes and urinary markers. " 11/01/2009 - "Effects of angiotensin II type 1 receptor blocker on ambulatory blood pressure variability in hypertensive patients with overt diabetic nephropathy." 09/01/2009 - "Angiotensin II type 1 receptor blockers (ARB) retard the progression of hypertensive diabetic kidney disease. "
3.	Hypertension (High Blood Pressure) 09/01/2009 - "Third, TROPHY (Trial of Preventing Hypertension) is the first pharmacological intervention for prehypertensive patients revealing that treatment with angiotensin II type 1 receptor blocker attenuates hypertension development and thus decreases the risk of cardiovascular events." 01/01/2019 - "Angiotensin II type 1 receptor blockers prevent aortic arterial stiffness in elderly patients with hypertension." 08/01/2015 - "Ang II-AT1 receptors play an important role in mediating virtually all of the physiological actions of Ang II. Several drugs (SARTANs) are available, which can block the AT1 receptor effectively and lower the blood pressure in the patients with hypertension. " 08/01/2014 - "Angiotensin II type 1 receptor blockers (ARBs) are widely used in treating hypertension. " 03/01/2013 - "How important is it to control nocturnal hypertension with angiotensin II type 1 receptor blockers?"
4.	Stroke (Strokes) 01/01/2012 - "In this review, the beneficial effects of sartans in the management of stroke are discussed, considering the results of experimental and clinical studies." 04/01/2001 - "The aim of this study was to evaluate the effect of different angiotensin II type 1 receptor antagonists in stroke-prone spontaneously hypertensive rats (SHRSP). " 03/07/2020 - "In this review, we discuss the role of Sartans in the treatment of stroke and their potential impact in aSAH. " 01/01/2012 - "In humans, sartans are safe in hypertensive acute stroke patients and may offer advantages independent of blood pressure control. " 01/01/2012 - "The anti-inflammatory effects of sartans play a role in reducing cerebral injury following stroke, and improve the outcome of stroke in terms of improving cognitive function. "
5.	Hepatocellular Carcinoma (Hepatoma) 10/08/2020 - "Sartans significantly improved time to recurrence after radiofrequency ablation in hepatocellular carcinoma patients but did not improve overall survival." 11/01/2015 - "Sartans significantly improved overall survival and time to recurrence after radiofrequency ablation in hepatocellular carcinoma patients." 10/08/2020 - "Aim of the study was to evaluate whether sartans delay time to recurrence and prolong overall survival in hepatocellular carcinoma patients after radiofrequency ablation. " 11/01/2015 - "The aim of the study was to evaluate whether sartans delay time to recurrence and prolong overall survival in hepatocellular carcinoma patients after radiofrequency ablation. " 05/28/2019 - "We performed an electronic search of the literature using the most accessed online databases (PubMed, Cochrane library, Scopus and Web of Science), entering the query terms "angiotensin-converting enzyme inhibitors" OR "ACE inhibitors" OR "ACE-I" AND "hepatocarcinoma" OR "hepatocellular carcinoma; moreover "angiotensin II type 1 receptor blockers" OR "ARBs" AND "hepatocarcinoma" OR "hepatocellular carcinoma". "

Related Drugs and Biologics

1.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
2.	Losartan (Cozaar)
3.	candesartan
4.	Telmisartan (Micardis)
5.	Angiotensin Receptor Antagonists
6.	Calcium Channel Blockers (Blockers, Calcium Channel)
7.	Valsartan (Vals)
8.	Antihypertensive Agents (Antihypertensives)
9.	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)
10.	Diuretics

Related Therapies and Procedures

1.	Therapeutics
2.	Radiofrequency Ablation
3.	Secondary Prevention
4.	Stents
5.	Aftercare (After-Treatment)