Eosinophil Peroxidase

A 66-kDa peroxidase found in EOSINOPHIL granules. Eosinophil peroxidase is a cationic protein with a pI of 10.8 and is comprised of a heavy chain subunit and a light chain subunit. It possesses cytotoxic activity towards BACTERIA and other organisms, which is attributed to its peroxidase activity.

Also Known As:

Networked: 203 relevant articles (4 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lee, James J: 7 articles (01/2019 - 05/2004)
2.	Mukherjee, Manali: 4 articles (10/2022 - 01/2018)
3.	Evdokiou, Andreas: 4 articles (02/2022 - 05/2015)
4.	Wright, Benjamin L: 4 articles (11/2021 - 11/2017)
5.	Konduri, Kameswari S: 4 articles (01/2021 - 02/2003)
6.	Nair, Parameswaran: 3 articles (10/2022 - 01/2018)
7.	Doyle, Alfred D: 3 articles (11/2021 - 01/2019)
8.	Antunes, Géssica Luana: 3 articles (10/2021 - 12/2019)
9.	Silveira, Josiane Silva: 3 articles (10/2021 - 12/2019)
10.	da Cunha, Aline Andrea: 3 articles (10/2021 - 12/2019)

Related Diseases

1.	Asthma (Bronchial Asthma) 04/01/2016 - "The objective of the study was to compare nasal, pharyngeal, and sputum eosinophil peroxidase (EPX) levels with induced sputum eosinophil percentage in 10 adults with poorly controlled asthma and 10 normal controls. " 10/14/2016 - "Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma." 08/15/2001 - "Eosinophil peroxidase has been implicated in promoting oxidative tissue damage in a variety of inflammatory conditions, including asthma. " 04/01/2016 - "Nasal and pharyngeal eosinophil peroxidase levels in adults with poorly controlled asthma correlate with sputum eosinophilia." 04/01/1997 - "In this study, the eosinophil peroxidase (EPO) levels were assessed in different stages of bronchial asthma, in 123 patients suffering from asthma, classified as mild (n =49), moderate (n = 49), and severe (n = 25), according to the International Consensus Report of Diagnosis and Treatment of Asthma, as well as in 27 healthy controls, with the aim of evaluating the importance of this protein as a severity marker in bronchial asthma, and its possible correlation with parameters such as anamnesis, respiratory function tests, and peripheral blood eosinophil count, and also with some allergologic diagnostic tests, both in vivo and in vitro. "
2.	Eosinophilia 12/28/2022 - "A sputum bioassay for airway eosinophilia using an eosinophil peroxidase aptamer." 09/01/2019 - "Researchers have shown that eosinophil peroxidase (EPO) is a relatively accurate marker of eosinophilia and eosinophil activity. " 08/01/2002 - "Eosinophilia (cell counts in the BALF and eosinophil peroxidase of lung tissue) was detected at 24 and 72 h with similar levels for air and 20 ppm NO(2), whereas a marked reduction was unexpectedly observed for 5 ppm NO(2). " 10/01/2000 - "Lung eosinophilia was evaluated by measurement of eosinophil peroxidase activity and confirmed by eosinophil counts in histologic sections. " 04/01/1997 - "Various disease states are associated with eosinophilia and the release of eosinophil peroxidase (EPO) into the microenvironment. "
3.	Colitis 07/21/2015 - "In addition to TNF secretion, release of eosinophil peroxidase promoted colitis identifying direct tissue-toxic mechanisms. " 02/19/2020 - "Bifidobacterium administration in the T group showed reduction in intestinal permeability and lower IL-1β, myeloperoxidase, and eosinophil peroxidase levels compared to those in the colitis group (P<0.05). " 01/01/2022 - "In addition, healthy donor (HD) bacteria significantly reduced the levels of inflammatory markers Myeloperoxidase (MPO) and Eosinophil peroxidase (EPO), and various pro-inflammatory factors, in colitis mice, and increased the secretion of the anti-inflammatory factor IL-10. " 01/01/2018 - "The results showed that serine decreased the disease activity index, as well as myeloperoxidase, eosinophil peroxidase, and proinflammatory cytokine concentrations in colonic tissue, while serine improved colonic morphology and inhibited cell apoptosis in colitis mice. " 02/15/2015 - "DSS-induced colitis was characterized by higher disease activity index, shortened colon length, elevated activities of myeloperoxidase and eosinophil peroxidase, histologic evidence of inflammation, and increased expression levels of TNF-α, IL-6, and IL-8. "
4.	Body Weight (Weight, Body) 09/08/2022 - "Asp administration decreased the disease activity index, apoptosis, myeloperoxidase, eosinophil peroxidase, and proinflammatory cytokine (IL-1β and TNF-α) concentrations in the colonic tissue, but improved the body weight, average daily food intake, colonic morphology, and antioxidant-related gene (GPX1 and GPX4) expression in DSS-treated mice. "
5.	Lymphoma (Lymphomas) 12/01/1986 - "Extensive deposition of eosinophil peroxidase in Hodgkin's and non-Hodgkin's lymphomas." 08/01/1992 - "Phase I imaging study of Hodgkin's disease and non-Hodgkin's lymphomas with radiolabeled antibody to eosinophil peroxidase." 08/01/1993 - "We conclude that a radiolabeled monoclonal antibody directed against eosinophil peroxidase localizes to lymphoma sites infiltrated by eosinophils." 08/01/1993 - "The purpose of this study was to determine if a radiolabeled murine monoclonal antibody (EOS) directed against eosinophil peroxidase would localize specifically to tumor sites in patients with lymphomas infiltrated by eosinophils. " 05/15/1994 - "These results are important because certain human lymphomas contain extensive extracellular deposits of eosinophil peroxidase, thereby making these tumors potentially less susceptible to killing by otherwise therapeutic doses of glucose oxidase."

Related Drugs and Biologics

1.	Peroxidase (Myeloperoxidase)
2.	Cytokines
3.	Biomarkers (Surrogate Marker)
4.	Interleukin-5 (Interleukin 5)
5.	Allergens
6.	Antioxidants
7.	bromotyrosine
8.	Interleukin-3 Receptors (Interleukin 3 Receptor)
9.	Serine (L-Serine)
10.	Eosinophil Cationic Protein

Related Therapies and Procedures

1.	Therapeutics