Eosinophil Peroxidase

A 66-kDa peroxidase found in EOSINOPHIL granules. Eosinophil peroxidase is a cationic protein with a pI of 10.8 and is comprised of a heavy chain subunit and a light chain subunit. It possesses cytotoxic activity towards BACTERIA and other organisms, which is attributed to its peroxidase activity.

Also Known As:

Networked: 130 relevant articles (0 outcomes, 12 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Lee, James J: 3 articles (05/2012 - 05/2004)
2.	Konduri, Kameswari S: 3 articles (09/2008 - 02/2003)
3.	Ackerman, Steven J: 2 articles (06/2014 - 05/2012)
4.	McKay, Derek M: 2 articles (06/2013 - 04/2007)
5.	Wang, Arthur: 2 articles (06/2013 - 04/2007)
6.	Nakae, Susumu: 2 articles (06/2012 - 03/2007)
7.	Martins, M A: 2 articles (12/2010 - 07/2005)
8.	Macedo, M S: 2 articles (12/2010 - 07/2005)
9.	Macedo-Soares, M F: 2 articles (12/2010 - 07/2005)
10.	Perini, A: 2 articles (12/2010 - 07/2005)

Related Diseases

1.	Asthma (Bronchial Asthma) 04/01/1997 - "In this study, the eosinophil peroxidase (EPO) levels were assessed in different stages of bronchial asthma, in 123 patients suffering from asthma, classified as mild (n =49), moderate (n = 49), and severe (n = 25), according to the International Consensus Report of Diagnosis and Treatment of Asthma, as well as in 27 healthy controls, with the aim of evaluating the importance of this protein as a severity marker in bronchial asthma, and its possible correlation with parameters such as anamnesis, respiratory function tests, and peripheral blood eosinophil count, and also with some allergologic diagnostic tests, both in vivo and in vitro. " 04/01/2006 - "EH A001 prevented eosinophil accumulation and eosinophil peroxidase activity and reduced the protein content in bronchoalveolar lavage fluid (BALF) in a 'mild' model of asthma. " 03/01/2003 - "Eosinophil peroxidase (EPO) is an eosinophilic basic protein, which leads to increased permeability and damage of bronchial epithelial cells in asthma. " 03/01/2003 - "Local release of eosinophil peroxidase following segmental allergen provocation in asthma." 08/15/2001 - "Eosinophil peroxidase has been implicated in promoting oxidative tissue damage in a variety of inflammatory conditions, including asthma. "
2.	Lymphoma (Lymphomas) 08/01/1993 - "We conclude that a radiolabeled monoclonal antibody directed against eosinophil peroxidase localizes to lymphoma sites infiltrated by eosinophils." 12/01/1986 - "Extensive deposition of eosinophil peroxidase in Hodgkin's and non-Hodgkin's lymphomas." 08/01/1992 - "Phase I imaging study of Hodgkin's disease and non-Hodgkin's lymphomas with radiolabeled antibody to eosinophil peroxidase." 08/01/1993 - "Radioimmunodetection of Hodgkin's disease and non-Hodgkin's lymphomas with monoclonal antibody to eosinophil peroxidase." 08/01/1993 - "The purpose of this study was to determine if a radiolabeled murine monoclonal antibody (EOS) directed against eosinophil peroxidase would localize specifically to tumor sites in patients with lymphomas infiltrated by eosinophils. "
3.	Inflammation 12/01/2010 - "Two days after the last challenge, the airway inflammation was evaluated by antibody levels, cellular migration, eosinophil peroxidase levels, cytokine and eotaxin production, and pulmonary mechanical parameters. " 11/01/2008 - "A similar trend was recorded for eosinophil peroxidase activity (P < 0.05), indicating the role of proteolytic activity in inducing inflammation. " 07/01/2005 - "Two days after the last challenge, the allergic airway inflammation was evaluated by cellular migration, eosinophil peroxidase (EPO) activity, cytokine and chemokine production and pulmonary mechanical parameters. " 10/01/2001 - "Eosinophil peroxidase mediates protein nitration in allergic airway inflammation in mice." 02/20/2001 - "These findings raise the possibility that halogenated nucleobases generated by eosinophil peroxidase exert cytotoxic and mutagenic effects at eosinophil-rich sites of inflammation."
4.	Infection 09/01/2006 - "Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection." 12/01/2005 - "Eosinophils, but not eosinophil peroxidase or major basic protein, are important for host protection in experimental Brugia pahangi infection." 01/01/2005 - "Eosinophil peroxidase levels were high during primary, but not secondary infection, suggesting that eosinophil degranulation is important during primary Mf clearance. " 04/01/2002 - "Here, we adapted a colorimetric assay to measure eosinophil peroxidase (EPO) activity in inflamed mouse lung tissue in order to quantitate pulmonary eosinophilia during experimental RSV infection. " 04/01/2002 - "Sensitive detection and quantitation of mouse eosinophils in tissues using an enzymatic eosinophil peroxidase assay: its use to rapidly measure pulmonary eosinophilia during experimental respiratory syncytial virus infection of mice."
5.	Neoplasms (Cancer) 05/01/1982 - "Eosinophil peroxidase (EPO), a cationic protein purified from horse blood, adhered to four different types of tumor cells, markedly potentiating their lysis by preformed or enzymatically generated H(2)0(2) (up to 76-fold, as assayed in serum-containing tissue culture medium without supplemental halide). " 02/20/2001 - "Eosinophil recruitment is a hallmark of parasitic infections and many forms of cancer, and eosinophil peroxidase (EPO), a secreted hemoprotein, plays a central role in oxidant production by these cells. " 09/03/1999 - "Eosinophil peroxidase (EPO) has been implicated in promoting oxidative tissue injury in conditions ranging from asthma and other allergic inflammatory disorders to cancer and parasitic/helminthic infections. " 03/23/1999 - "Eosinophil peroxidase (EPO), an abundant protein secreted from activated eosinophils, has been implicated in promoting oxidative tissue injury in conditions such as asthma, allergic inflammatory disorders, cancer, and helminthic infections. " 08/01/1993 - "The purpose of this study was to determine if a radiolabeled murine monoclonal antibody (EOS) directed against eosinophil peroxidase would localize specifically to tumor sites in patients with lymphomas infiltrated by eosinophils. "

Related Drugs and Biologics

1.	Eosinophil Cationic Protein
2.	Peroxidase (Myeloperoxidase)
3.	Eosinophil Granule Proteins
4.	Immunoglobulin E (IgE)
5.	Immunoglobulin G (IgG)
6.	Lipocalins
7.	Granzymes (Granzyme)
8.	Biological Markers (Surrogate Marker)
9.	Theophylline (Theon)
10.	Superoxides (Superoxide)