Eosinophil-Derived Neurotoxin

A 19-kDa cationic peptide found in EOSINOPHIL granules. Eosinophil-derived neurotoxin is a RIBONUCLEASE and may play a role as an endogenous antiviral agent.
Also Known As:
Eosinophil Protein X; RNS2 Neurotoxin; Serum Eosinophil Protein X; s-EPX; Eosinophil Derived Neurotoxin; Neurotoxin, Eosinophil-Derived; Neurotoxin, RNS2
Networked: 121 relevant articles (6 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Kim, Chang-Keun: 4 articles (05/2013 - 05/2010)
2. Kita, Hirohito: 4 articles (07/2012 - 04/2003)
3. Fujisawa, Takao: 3 articles (05/2013 - 05/2010)
4. Callaway, Zak: 3 articles (05/2013 - 05/2010)
5. Carlson, Marie: 3 articles (11/2012 - 07/2002)
6. Halmerbauer, G: 3 articles (09/2001 - 07/2000)
7. Bjerknes, R: 3 articles (08/2001 - 10/2000)
8. Oymar, K: 3 articles (08/2001 - 10/2000)
9. Chang, Hao-Teng: 2 articles (01/2013 - 01/2013)
10. Sangfelt, Per: 2 articles (11/2012 - 09/2008)

Related Diseases

1. Asthma (Bronchial Asthma)
2. Inflammation
3. Hypersensitivity (Allergy)
09/01/2004 - "To identify phenotypic differences in eosinophil-derived neurotoxin (EDN) content and release in eosinophils from healthy patients, those with allergy, and those with allergy and asthma. "
12/01/2000 - "Eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EPX) are cytotoxic molecules involved in helminth infections and allergic reactions. "
01/01/1997 - "3. Circulating eosinophils of VKC patients show a typical activation phenotypic profile which is associated with increased serum level of eosinophil cationic protein and eosinophil-derived neurotoxin/protein X. A clinical study of the modulatory effect of cetirizine on the early and late phase of the allergic reaction as well as on the eosinophil activation and tissue recruitment following conjunctival allergen challenge is reported as an example of the need to evaluate eosinophil functions when investigating anti-allergic drugs. "
09/01/2001 - "We measured eosinophil protein X (EPX) and leukotriene E(4) (LTE(4)) in urine, as well as eosinophil cationic protein (ECP) in nasal lavages, in a random sample of 1-year-old children with a family history of atopy who participated in an international multicenter study on the prevention of allergy in Europe. "
04/01/2012 - "To assess, in a group of patients with IBD in remission or with a mild disease activity, whether serological markers of eosinophil activation, eosinophil cationic protein (ECP) and eosinophil protein X (EPX), are related to evidence of IgE hypersensitivity and to the eosinophilia in gut mucosa. "
4. Atopic Dermatitis (Atopic Eczema)
5. Gastroesophageal Reflux (GERD)

Related Drugs and Biologics

1. Eosinophil Cationic Protein
2. Tryptases (Tryptase)
3. Leukotriene E4
4. Budesonide (Pulmicort)
5. Peroxidase (Myeloperoxidase)
6. Immunoglobulin E (IgE)
7. Proton Pump Inhibitors
8. Estradiol (Estrace)
9. Proteins (Proteins, Gene)
10. Biological Markers (Surrogate Marker)

Related Therapies and Procedures

1. Aftercare (After-Treatment)