Eosinophil Cationic Protein

One of several basic proteins released from EOSINOPHIL cytoplasmic granules. Eosinophil cationic protein is a 21-kDa cytotoxic peptide with a pI of 10.9. Although eosinophil cationic protein is considered a member of the RNAse A superfamily of proteins, it has only limited RNAse activity.

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Networked: 721 relevant articles (13 outcomes, 99 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chang, Margaret Dah-Tsyr: 7 articles (02/2015 - 09/2004)
2.	Bachert, Claus: 7 articles (01/2013 - 06/2005)
3.	Venge, Per: 5 articles (12/2014 - 03/2004)
4.	Chang, Hao-Teng: 5 articles (05/2013 - 09/2004)
5.	Koh, Young Yull: 5 articles (06/2010 - 07/2003)
6.	Reimert, C M: 5 articles (06/2006 - 02/2000)
7.	Venge, P: 5 articles (03/2004 - 04/2000)
8.	Maruyama, Kenichi: 4 articles (09/2015 - 01/2010)
9.	Hayashi, Yasuhide: 4 articles (09/2015 - 01/2010)
10.	Kato, Masahiko: 4 articles (09/2015 - 01/2010)

Related Diseases

1.	Asthma (Bronchial Asthma) 07/01/2003 - "Ratio of serum eosinophil cationic protein/blood eosinophil counts in children with asthma: comparison between acute exacerbation and clinical remission." 07/01/2002 - "Accuracy of eosinophils and eosinophil cationic protein to predict steroid improvement in asthma." 05/01/2013 - "The goal of this study was to evaluate the feasibility of in vivo radionuclide imaging of HS side chain expression in a mouse model of asthma using the recombinant eosinophil cationic protein (rECP). " 09/01/2012 - "Our study aims to assess the importance of serum eosinophil cationic protein (ECP) levels as a non-invasive marker of bronchial hyperresponsiveness (BHR) in children with asthma, and may predict objectively the asthmatic severity and sensitivities. " 09/01/2009 - "The aim of this study was to evaluate whether eosinophil Cationic Protein (ECP) could be an accurate diagnostic marker of mild asthma. "
2.	Inflammation 02/01/2015 - "To evaluate participation of eosinophils in the meconium-induced inflammation, eosinophil cationic protein (ECP) was detected in plasma and lung homogenate. " 04/01/2014 - "Direct measures, which quantify but do not anatomically localise inflammation include blood eosinophil counts, serum or plasma eosinophil cationic protein and sputum eosinophil levels. " 12/01/2013 - "Eosinophil cationic protein (ECP) was reported previously to be involved in allergic inflammation with cytotoxic activity. " 05/01/2013 - "Eosinophil cationic protein (ECP) is a major granule-derived protein with cytotoxic activity found in eosinophils and has been known as a useful marker of allergic inflammation. " 09/12/2008 - "Eosinophil cationic protein (ECP) is currently used as a biomarker for airway inflammation. "
3.	Eosinophilia 07/01/2008 - "Three patients had peripheral blood eosinophilia and elevated eosinophil cationic protein. " 04/01/2006 - "During the active stage of the disease, most of the patients exhibited peripheral blood eosinophilia and an elevated serum eosinophil cationic protein level. " 06/01/2002 - "Under MT we induced an eosinophilia and an elevation of eosinophil cationic protein (ECP). " 11/01/1999 - "Evaluation of blood eosinophilia and the eosinophil cationic protein (ECP) in the serum of asthmatic children with varying degree of severity." 07/01/1999 - "The allergen challenges produced nasal symptoms, marked tissue eosinophilia, and an increase in lavage fluid levels of eosinophil cationic protein (ECP). "
4.	Hypersensitivity (Allergy) 02/01/1996 - "The aim of this study was to determine whether CFS patients, well studied for their allergy profile, show signs of eosinophil activation, as detectable by the measurement in serum of eosinophil cationic protein (ECP) levels. " 09/01/2014 - "Nasal eosinophil cationic protein (ECP) and exhaled breath condensate (EBC) markers (pH, 8-isoprostane, interleukin-1β) were not associated with symptoms or with nasal allergy. " 02/09/1997 - "It can be concluded that follow up of food allergic reaction can be regarded as a more exact with measure of the copro eosinophil cationic protein." 09/01/1996 - "The relationship between allergy and OME was corroborated clinically in 89% of patients and was also substantiated by elevated levels of effusion eosinophil cationic protein (ECP) in 87.5% of OME patients. " 04/01/1996 - "Middle ear eosinophil cationic protein may be used as a marker of related allergy."
5.	Respiratory Sounds (Crackle) 06/01/2000 - "At present, there are no disease markers to identify the different wheezing phenotypes in infancy, although eosinophil counts and measurements of eosinophil cationic protein in serum may prove to be helpful in distinguishing these conditions." 04/01/2001 - "In this study we investigated whether eosinophil cationic protein (ECP) levels are increased in BAL fluid (BALF) from infants and toddlers with recurrent wheezing episodes, during an asymptomatic period. " 10/01/2005 - "Elevated concentrations of eosinophil cationic protein (ECP) have been found in acute viral wheezing during infancy. " 06/01/2005 - "Bronchial responsiveness and serum eosinophil cationic protein levels in preschool children with recurrent wheezing." 12/01/2002 - "[Measurement of serum eosinophil cationic protein levels in wheezing infants]."

Related Drugs and Biologics

1.	Eosinophil-Derived Neurotoxin
2.	Immunoglobulin E (IgE)
3.	Tryptases (Tryptase)
4.	Inflammation Mediators
5.	Cromolyn Sodium (Cromoglicic Acid)
6.	Tacrolimus (Prograf)
7.	Complement C3 (C3 Complement)
8.	lodoxamide ethyl (lodoxamide)
9.	Peroxidase (Myeloperoxidase)
10.	Interleukin-5 (Interleukin 5)

Related Therapies and Procedures

1.	Immunotherapy
2.	Aftercare (After-Treatment)
3.	Drug Therapy (Chemotherapy)
4.	Phototherapy (Light Therapy)
5.	Myocardial Revascularization