beta-Glucans

Glucose polymers consisting of a backbone of beta(1->3)-linked beta-D-glucopyranosyl units with beta(1->6) linked side chains of various lengths. They are a major component of the CELL WALL of organisms and of soluble DIETARY FIBER.

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Networked: 499 relevant articles (64 outcomes, 116 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ohno, Naohito: 19 articles (07/2009 - 01/2002)
2.	Adachi, Yoshiyuki: 14 articles (07/2009 - 01/2002)
3.	Yan, Jun: 12 articles (11/2010 - 12/2003)
4.	Hansen, Richard: 9 articles (11/2010 - 08/2006)
5.	Miura, Noriko N: 8 articles (03/2009 - 01/2002)
6.	Gromadzka-Ostrowska, Joanna: 7 articles (01/2022 - 02/2015)
7.	Allendorf, Daniel J: 7 articles (01/2008 - 12/2003)
8.	Harasym, Joanna: 6 articles (08/2021 - 09/2015)
9.	Li, Bing: 6 articles (11/2010 - 08/2006)
10.	Limper, Andrew H: 6 articles (08/2010 - 01/2003)

Related Diseases

1.	Neoplasms (Cancer) 12/15/2003 - "In comparison with antitumor mAb or beta-glucan alone, combined treatment with mAb plus beta-glucan produced significantly greater tumor regression in all models that included mammary, s.c., and hepatic tumors. " 06/01/2009 - "It is proposed that the addition of beta-glucan will further improve the therapeutic efficacy of anti-tumor mAbs in cancer patients." 05/01/2005 - "It is proposed that the addition of beta-glucan will further improve the clinical therapeutic efficacy of antitumour mAbs in cancer patients." 08/01/2007 - "In vivo, administration of anti-CD55 mAb along with beta-glucan and anti-Her-2/neu mAb caused tumor regression and greatly improved long-term survival in animals bearing the previously resistant SKOV-3 tumors. " 01/01/2021 - "Fungal beta-glucans as adjuvants for treating cancer patients - A systematic review of clinical trials."
2.	Infections 03/15/2009 - "To our knowledge, this is the first in vivo study, in which the use of beta-glucans as feed ingredient for just-weaned piglets was tested for their protective effects against ETEC infection." 08/01/2009 - "The present study was conducted to investigate the effect of beta-glucan (derived from Saccharomyces cerevisiae) on the immune response and its protection against an infection of the bacterial pathogen Aeromonas hydrophila in zebrafish (Danio rerio). " 10/02/2022 - "Beta glucan exposure induced trained immunity in channel catfish that conferred long-term protection against Edwardsiella ictaluri and Edwardsiella piscicida infections one month post exposure. " 06/28/2022 - "Unrelated positive beta-glucan tests were observed in 49 patients (23.4%), including 6 with mold infections and 43 with false positive results. " 05/01/2019 - "(1) One hundred ninety-seven (197) women met the study criteria, of whom 58 (29.4%) had an IUD in place; (2) 20 (10.2%) women had a culture of proven intra-amniotic Candida species-related infection, 19 of whom had a positive beta-glucan assay [sensitivity, 95% (19/20; 95% confidence interval (CI): 75.1-99.9%)]; and (3) the specificity of the beta-glucan assay was 75.1% [133/177; 95% CI: 68.1-99.9%]. "
3.	Inflammation (Inflammations) 01/26/2022 - "Both groups of rats were further divided into three dietary subgroups, which were fed with standard feed or feed supplemented with low- or high-molar-mass oat beta-glucans for 3 (reflecting acute inflammation) or 7 days (reflecting pre-remission). " 04/19/2020 - "The purpose of this study was to identify the impact of yeast beta-glucan (Saccharomyces cerevisiae) supplementation on exercise-induced muscle damage and inflammation. " 04/01/2006 - "The current study examined an in vivo correlate of that observation by testing the hypothesis that systemic beta-glucan treatment would result in enhanced migration of neutrophils into a site of inflammation and improve antimicrobial function. " 11/01/2022 - "AFO-202 beta-glucan significantly decreased inflammation-associated hepatic cell ballooning and steatosis. " 04/30/2020 - "Time-Dependent Indirect Antioxidative Effects of Oat Beta-Glucans on Peripheral Blood Parameters in the Animal Model of Colon Inflammation."
4.	Candidiasis (Moniliasis) 02/01/2010 - "Our results demonstrate the efficacy of beta-glucan treatment for recurrent candidiasis, HPV-correlated lesions and in the reparative process of epidermis." 02/01/2000 - "The results of the PCR assay and beta-glucan test showed a significant correlation in this study, but the PCR assay proved to be more sensitive than the beta-glucan test (p < 0.05), and to be more useful for the clinical diagnosis and monitoring of deep Candidiasis." 02/01/2010 - "[Role of beta-glucan in the treatment of recurrent candidiasis and HPV-correlated lesions and reparative process of epidermis]." 11/01/2008 - "CSF beta-glucan levels correlated in a dose-dependent pattern with therapeutic responses and with Candida infection in cerebral tissue (r = 0.842). " 04/01/1990 - "But the beta-glucan measured by the conventional Limulus assay (toxicolor test), which contains the factor G, was elevated (from 10 pg/ml to 100 pg/ml) in all cases of rabbit model of system candidiasis. "
5.	Pneumonia (Pneumonitis) 01/01/2001 - "The level of beta-glucan confirmed mycotic pneumonia in 9 of these 58 patients (15.5%), and early treatment was effective in 7 of these (66.7%). " 03/28/2003 - "This study indicates that the partially opened triple helix of 1-->3-beta-glucans is more active than the closed conformation in inducing pulmonary inflammation in rats." 03/28/2003 - "The objective of this study was to examine the role of these conformations of 1-->3-beta-glucans in the induction of pulmonary inflammation in rats. " 01/10/2003 - "This study investigates which form of 1-->3-beta-glucans, particulate or soluble, is more potent in inducing pulmonary inflammation. " 06/15/2008 - "Use of a serum beta-glucan assay for diagnosis of HIV-related Pneumocystis jiroveci pneumonia in patients with negative microscopic examination results."

Related Drugs and Biologics

1.	Polysaccharides (Glycans)
2.	Antigens
3.	Monoclonal Antibodies
4.	Antibodies
5.	Lipids
6.	Bevacizumab (Avastin)
7.	Carbohydrates
8.	Dietary Fiber
9.	Melatonin
10.	Butyrates (Butyrate)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Biological Therapy
4.	Immunotherapy
5.	Ligation