Lymphocytic Colitis

A subtype of MICROSCOPIC COLITIS, characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. Microscopic examination of biopsy samples taken from the COLON show infiltration of LYMPHOCYTES in the superficial EPITHELIUM and the underlying connective tissue (lamina propria).

Also Known As:

Networked: 155 relevant articles (11 outcomes, 10 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Collagenous Colitis
2.	Ulcerative Colitis
3.	Colitis
4.	Celiac Disease (Celiac Sprue)
5.	Microscopic Colitis

Experts

1.	Chande, Nilesh: 4 articles (07/2010 - 04/2007)
2.	Rubio, Carlos A: 3 articles (12/2015 - 06/2011)
3.	Tysk, C: 3 articles (11/2013 - 05/2000)
4.	Pardi, Darrell S: 3 articles (11/2004 - 04/2002)
5.	Geboes, Karel: 2 articles (01/2016 - 04/2015)
6.	Münch, Andreas: 2 articles (04/2015 - 01/2015)
7.	Miehlke, Stephan: 2 articles (04/2015 - 06/2009)
8.	Lin, Jingmei: 2 articles (02/2015 - 01/2014)
9.	Tysk, Curt: 2 articles (09/2014 - 09/2009)
10.	Bohr, J: 2 articles (11/2013 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lymphocytic Colitis:

1.	Budesonide (Pulmicort)FDA LinkGeneric 02/01/1998 - "We report the case of a female patient suffering from severe lymphocytic colitis who remained unresponsive after 5-ASA therapy but who improved dramatically after oral budesonide administration." 06/01/2009 - "Budesonide effectively induces clinical remission in patients with lymphocytic colitis and significantly improves histology results after 6 weeks. " 06/01/2009 - "Budesonide is effective in treating lymphocytic colitis: a randomized double-blind placebo-controlled study." 01/01/2008 - "A single trial studying budesonide suggests that it may be effective for the treatment of active lymphocytic colitis. " 09/01/2009 - "Large intestine: Remission of lymphocytic colitis with budesonide."
2.	Mesalamine (Mesalazine)FDA LinkGeneric 04/01/1999 - "We herein present a new case of hepatoxicity by mesalazine in a patient with lymphocytic colitis. " 03/01/2012 - "MPA: a treatment option for lymphocytic colitis and mesalamine-induced interstitial nephritis." 01/01/2008 - "There is weaker evidence that mesalazine with or without cholestyramine may be effective for the treatment of lymphocytic colitis, but this benefit needs to be confirmed in a placebo-controlled study. " 07/01/2000 - "Tablets of coated 5-aminosalicylate (5-ASA) called mesalazines are among the most widely prescribed preparations for the treatment of colitis, including ulcerative, Crohn's disease (CD), collagenous and lymphocytic colitis, and-to a lesser extent-CD of the small bowel. " 01/01/2009 - "Bismuth subsalicylate and mesalamine with or without cholestyramine may be effective for treating lymphocytic colitis. "
3.	Cholestyramine Resin (Questran)FDA LinkGeneric 01/01/2008 - "There is weaker evidence that mesalazine with or without cholestyramine may be effective for the treatment of lymphocytic colitis, but this benefit needs to be confirmed in a placebo-controlled study. " 01/01/2009 - "Bismuth subsalicylate and mesalamine with or without cholestyramine may be effective for treating lymphocytic colitis. "
4.	bismuth subsalicylate (Pepto-bismol)FDA LinkGeneric 01/01/2007 - "A single trial studying bismuth subsalicylate as therapy for lymphocytic colitis suggests that it may be beneficial. " 01/01/2007 - "A single randomized trial published in abstract form only which studied bismuth subsalicylate was identified, and included only 5 patients with lymphocytic colitis (and 9 with collagenous colitis). " 01/01/2007 - "There were 5 patients with lymphocytic colitis in the trial studying bismuth subsalicylate (nine 262 mg tablets daily for 8 weeks vs. placebo). " 01/01/2009 - "Bismuth subsalicylate and mesalamine with or without cholestyramine may be effective for treating lymphocytic colitis. "
5.	Ticlopidine (Ticlid)FDA LinkGeneric 09/01/1999 - "Histological damages from lymphocytic colitis improved six month after he had stopped taking ticlopidine. " 08/01/2000 - "[Lymphocytic colitis during treatment with ticlopidine]." 11/01/1999 - "Lymphocytic colitis, induced by ticlopidine." 09/01/1999 - "[Ticlopidine-induced lymphocytic colitis]." 04/09/1998 - "[Lymphocytic colitis during ticlopidine therapy]."
6.	RNA (Ribonucleic Acid)IBA 09/14/2014 - "Total RNA and microRNA were isolated from fresh frozen colonic biopsies of non-inflamed controls and patients with active or in-remission collagenous colitis (CC), lymphocytic colitis (LC), or ulcerative colitis (UC). " 01/01/2014 - "Small RNA was extracted from formalin-fixed, paraffin-embedded (FFPE) colon tissue and qRT-PCR was performed from cohorts of normal control (n=38), ulcerative colitis (n=36), Crohns disease (n=26), collagenous colitis (n=36), lymphocytic colitis (n=30), and patients with intermittent features of IBD and MC (n=6). "
7.	MicroRNAs (MicroRNA)IBA 09/14/2014 - "Total RNA and microRNA were isolated from fresh frozen colonic biopsies of non-inflamed controls and patients with active or in-remission collagenous colitis (CC), lymphocytic colitis (LC), or ulcerative colitis (UC). "
8.	CollagenIBA 01/01/2015 - "Lymphocytic colitis is characterized by an increased number of intraepithelial lymphocytes, and CC by a thickened subepithelial collagen band, whereas in both an increased mononuclear infiltration of the lamina propria is found. " 11/01/2004 - "The 2 subtypes, collagenous and lymphocytic colitis, are similar clinically and histologically, and are distinguished by the presence or absence of a thickened subepithelial collagen band. " 05/01/2003 - "Histopathologic examination of biopsy specimens showed lymphocytic infiltration of the mucosa and some collagen deposits, consistent with a diagnosis of lymphocytic colitis. " 04/01/2002 - "The two main subtypes, collagenous and lymphocytic colitis, are similar clinically and histologically, distinguished by the presence or absence of a thickened subepithelial collagen band. " 10/23/1998 - "[Collagen and lymphocytic colitis]."
9.	Immunoglobulin A (IgA)IBA 02/01/1999 - "Linear IgA disease associated with lymphocytic colitis." 08/01/2003 - "None of 109 controls, including 55 cases of inflammatory bowel disease and one of lymphocytic colitis, had IGA. " 06/01/1999 - "Association of lymphocytic colitis with linear IgA dermatosis." 12/01/2000 - "A quantitative ELISA was used to measure titres of immunoglobulin A (IgA) antibody to tissue transglutaminase (tTG) along with an immunofluorescent technique for IgA endomysium antibody (EmA) in 15 patients with lymphocytic colitis and eight with collagenous colitis to determine whether celiac disease latency could be detected. " 06/01/1999 - "To our knowledge, the present report describes for the first time the association of linear IgA dermatosis with lymphocytic colitis after oral treatment with nystatin. "
10.	Glutens (Glutelin)IBA 11/01/1996 - "Two patients with lymphocytic colitis and normal small intestinal biopsies who were administered 40 g of added dietary gluten for four consecutive weeks are presented. " 11/01/1996 - "Failure of added dietary gluten to induce small intestinal histopathological changes in patients with watery diarrhea and lymphocytic colitis." 11/01/1996 - "Although microscopic forms of colitis have been linked to celiac disease, this study indicates that lymphocytic colitis is a heterogeneous clinicopathological disorder that, in some patients, is independent of any gluten-induced intestinal pathological changes." 01/01/2014 - "Only recently, lysozyme was found up-regulated in Barrett's oesophagitis, chronic gastritis, gluten-induced atrophic duodenitis (coeliac disease), collagenous colitis, lymphocytic colitis, and Crohn's colitis. " 12/01/2015 - "Lysozyme was recently found up-regulated in Barrett's esophagitis, in chronic gastritis, in gluten-induced atrophic duodenitis (celiac disease), in collagenous colitis, in lymphocytic colitis and in Crohn's colitis. "

Therapies and Procedures

1.	Remission Induction 07/01/2010 - "It is well proven to be effective in the induction of remission in collagenous colitis but its use in lymphocytic colitis remains less well documented. "
2.	Colectomy 01/01/2002 - "Colectomy with continent reconstruction is an option for treatment of patients with lymphocytic colitis refractory to medical therapy." 01/01/2002 - "Notably, the characteristic microscopic changes of lymphocytic colitis were still present at the time of colectomy despite diversion. " 05/01/1996 - "Interchange between collagenous and lymphocytic colitis in severe disease with autoimmune associations requiring colectomy: a case report."
3.	Aftercare (After-Treatment) 12/01/1998 - "Mild colonic lymphocytosis in patients with untreated celiac sprue should be distinguished from lymphocytic colitis by the lack of surface epithelial abnormalities, the lack of increased cellularity of the lamina propria, and the lack of ongoing watery diarrhea after treatment with a gluten-free diet. " 12/01/1998 - "[Lymphocytic colitis and villous atrophy after treatment with ticlopidine]."
4.	Colonic Pouches (S Pouch) 01/01/2002 - "Lymphocytic colitis treated with proctocolectomy and ileal J-pouch-anal anastomosis: report of a case."
5.	Sigmoidoscopes 09/01/1992 - "To determine: (1) whether there is an association between collagenous colitis and coeliac disease or lymphocytic colitis; (2) the distribution of lymphocyte subsets and macrophages in the lamina propria and surface epithelial layer in collagenous colitis; and (3) the colorectal distribution of the disease and whether a mucosal biopsy specimen, using a flexible sigmoidoscope, is sufficient to diagnose it. "