Pyogenic Liver Abscess

Single or multiple areas of PUS due to bacterial infection within the hepatic parenchyma. It can be caused by a variety of BACTERIA, local or disseminated from infections elsewhere such as in APPENDICITIS; CHOLECYSTITIS; PERITONITIS; and after LIVER TRANSPLANTATION.

Also Known As:

Liver Abscess, Pyogenic; Pyogenic Hepatic Abscess; Abscess, Pyogenic Hepatic; Abscess, Pyogenic Liver; Abscesses, Pyogenic Hepatic; Abscesses, Pyogenic Liver; Hepatic Abscess, Pyogenic; Hepatic Abscesses, Pyogenic; Liver Abscesses, Pyogenic; Pyogenic Hepatic Abscesses; Pyogenic Liver Abscesses

Networked: 301 relevant articles (19 outcomes, 28 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Liver Abscess
2.	Abscess
3.	Infections
4.	Bacteremia
5.	Coinfection

Experts

1.	Lin, Cheng-Li: 8 articles (03/2018 - 01/2015)
2.	Liao, Kuan-Fu: 7 articles (03/2018 - 04/2008)
3.	Wang, Jin-Town: 6 articles (02/2022 - 06/2008)
4.	Lai, Shih-Wei: 6 articles (03/2018 - 01/2015)
5.	Lin, Tzu-Lung: 5 articles (02/2022 - 06/2008)
6.	Wu, Shih-Hsiung: 4 articles (02/2022 - 01/2011)
7.	Chuah, Seng-Kee: 4 articles (01/2021 - 01/2019)
8.	Lee, Chen-Hsiang: 4 articles (01/2021 - 01/2019)
9.	Hsieh, Pei-Fang: 4 articles (12/2014 - 06/2008)
10.	Chang, Feng-Yee: 4 articles (07/2011 - 08/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pyogenic Liver Abscess:

1.	Anti-Bacterial Agents (Antibiotics)IBA 01/01/2001 - "Despite continuous improvement in image modalities, availability of potent antibiotics and advancement in the knowledge and treatment of pyogenic liver abscess, mortality remains high. " 04/01/1989 - "The marked reduction in the mortality rate of pyogenic liver abscess witnessed in this decade is multifaceted and attributable in part to earlier diagnosis, permitting definitive treatment in a timely fashion, as well as to improved intensive unit care, antibiotic management, and operative technique." 02/01/2001 - "Treatment of pyogenic liver abscesses should be tailored to each patient, however, the majority of them can be successfully treated with antibiotics and percutaneous methods. " 06/01/2002 - "A sequential intravenous/oral antibiotic regime is a safe and effective treatment for pyogenic liver abscess. " 06/01/2002 - "In this retrospective analysis, the efficacy of continuous intravenous antibiotic therapy (group I) vs. sequential intravenous/oral antibiotic therapy (group II) was studied in patients with pyogenic liver abscess. "
2.	Penicillins (Penicillin)FDA Link 02/01/1951 - "Multiple pyogenic liver abscesses cured with massive doses of penicillin." 03/21/1946 - "Pyogenic liver abscess; review of the literature and report of a case successfully treated by operation and penicillin."
3.	beta-Lactamases (beta-Lactamase)IBA 01/01/2017 - "Within 67 pyogenic liver abscess patients caused by Enterobacteriaceae expressing extended-spectrum beta-lactamases, the occurrences of 48 pyogenic liver abscess patients (71.6%) were associated with biliary disorders. " 01/01/2017 - "Of 176 pyogenic liver abscess patients related to biliary disorders, there were 48 pyogenic liver abscess patients (27.3%) caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae. " 01/01/2017 - "Among 817 pyogenic liver abscess patients, there were 176 patients (21.5%) with pyogenic liver abscess of biliary origin, and 67 pyogenic liver abscess patients (8.2%) caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates (mainly Escherichia coli and Klebsiella pneumoniae). " 01/01/2017 - "An analysis between pyogenic liver abscess patients caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates and those caused by non-extended-spectrum beta-lactamase-producing Enterobacteriaceae was performed. " 01/01/2017 - "Little is known about aetiology and morbidity and clinical characteristics of pyogenic liver abscess caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae. "
4.	Proton Pump InhibitorsIBA 08/01/2017 - "The objective of this study was to evaluate the correlation between proton pump inhibitors use and pyogenic liver abscess in Taiwan. " 10/30/2021 - "Proton Pump Inhibitor Use Increases Pyogenic Liver Abscess Risk: A Nationwide Cohort Study." 10/30/2021 - "Risk of Pyogenic Liver Abscess in Proton Pump Inhibitor Users: New Inventory of Proton Pump Inhibitor Induced Complications?" 06/01/2021 - "Is the Use of Proton Pump Inhibitors a Predisposing Factor for Pyogenic Liver Abscesses?" 03/01/2018 - "Treatment with proton pump inhibitors is associated with increased mortality in patients with pyogenic liver abscess."
5.	C-Reactive ProteinIBA 11/21/2019 - "Serum levels of SAA and CRP (C-reactive protein) were positively correlated in patients with CHB (P < 0.001), pyogenic liver abscess (P = 0.045), and active AILD (P = 0.02). " 02/01/2014 - "Role of C-reactive protein in response-guided therapy of pyogenic liver abscess." 10/14/2010 - "Clinical significance of C-reactive protein values in antibiotic treatment for pyogenic liver abscess." 07/21/2022 - "The purpose of the current study was to evaluate the association between C-reactive protein-to-platelet ratio (CPR), neutrophil-to-lymphocyte*platelet ratio (NLPR) and fibrinogen-to-platelet ratio (FPR) and the prognoses of pyogenic liver abscess (PLA) patients. "
6.	Therapeutic UsesIBA 10/14/2011 - "To investigate the feasibility and therapeutic effect of laparoscopic surgery for pyogenic liver abscess (PLA) with biliary pathology. " 01/01/2023 - "This study determined the therapeutic effect of ulinastatin (UTI) on unliquefied pyogenic liver abscesses complicated by septic shock (UPLA-SS). " 01/01/2023 - "Furthermore, the β-peptide polymer also showed excellent therapeutic effect Escherichia coli pyogenic liver abscess. "
7.	OzoneIBA 01/01/2018 - "The Value of Ozone in CT-Guided Drainage of Multiloculated Pyogenic Liver Abscesses: A Randomized Controlled Study." 01/01/2018 - "This study was designed to compare the effects of catheter drainage alone and combined with ozone in the management of multiloculated pyogenic liver abscess (PLA). " 01/01/2018 - "To compare the treatment efficacy of percutaneous catheter drainage alone to catheter drainage combined with ozone in the management of pyogenic liver abscess (PLA). " 01/01/2018 - "Computed tomography-guided catheter drainage with ozone in management of pyogenic liver abscess."
8.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 12/07/2020 - "In this study, we aimed to investigate the impact of aspirin on the risk of pyogenic liver abscess caused by Klebsiella pneumoniae (KP-PLA) and invasive KP-PLA syndrome (IKPS) in diabetic patients. " 01/01/2019 - "Aspirin possesses anti-bacterial activity that may prevent recurrence of Klebsiella pneumoniae pyogenic liver abscess (KP-PLA). " 01/01/2019 - "Aspirin use is associated with reduced risk for recurrence of pyogenic liver abscess: a propensity score analysis."
9.	Adrenal Cortex Hormones (Corticosteroids)IBA 03/01/2018 - "The aim of the study was to assess whether oral corticosteroid use is associated with increased odds of pyogenic liver abscesses in adults in Taiwan. " 03/01/2018 - "Although the findings are not unexpected, they are important because they suggest that current use of oral corticosteroids is significantly associated with increased odds of developing pyogenic liver abscesses in adults in Taiwan, with a dose-dependent effect." 03/01/2018 - "Upon further analysis, the adjusted odds ratio of pyogenic liver abscesses was 1.03 for subjects with current use of oral corticosteroids when increasing dosage for every one mg (95% CI 1.01, 1.06). " 03/01/2018 - "After regulating for confounders, the adjusted odds ratio of pyogenic liver abscesses was 1.40 for subjects currently using oral corticosteroids (95% confidence interval 1.14, 1.70), compared with subjects who never used them. " 03/01/2018 - "A multivariable logistic regression model was used to assess the odds ratio and 95% confidence interval for the correlation of oral corticosteroid use with pyogenic liver abscesses. "
10.	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 08/01/2017 - "The objective of the study was to determine whether prior use of statins is associated with pyogenic liver abscess. " 08/01/2017 - "Our findings provide strong evidence that patients with current use of statins are associated with a 35% reduced odds of pyogenic liver abscess. " 08/01/2017 - "Relative risk of pyogenic liver abscess associated with statin use was estimated by the odds ratio (OR) with 95% confidence interval (CI) using the multivariable logistic regression model. " 08/01/2017 - "Statin use was defined as 'current', 'recent' or 'past' if the statin prescription was filled ≤3 months, 3-6 months or >6 months before the date of pyogenic liver abscess diagnosis, respectively. " 08/01/2017 - "Little research is available on the relationship between statin use and pyogenic liver abscess. "

Therapies and Procedures

1.	Catheters 12/01/2003 - "Our study revealed that the most common organism was Klebsiella pneumoniae and percutaneous needle aspiration and/or catheter drainage were safe and effective treatment modalities for pyogenic liver abscess. " 07/01/2017 - "PCD was effective first-line treatment of complicated pyogenic liver abscesses, which often require catheter adjustment and salvage drainage procedures to reliably achieve success." 12/01/2022 - "Percutaneous catheter drainage (PCD) has been viewed as first-line treatment for pyogenic liver abscess (PLA), yet detailed guidance is lacking for best practice of PCD. " 11/11/2022 - "Percutaneous catheter drainage is the first-line treatment for pyogenic liver abscess (PLA). " 01/01/2018 - "Currently, percutaneous catheter drainage (PCD) is regarded as the first-line treatment modality of pyogenic liver abscess. "
2.	Therapeutics 08/01/1998 - "In the present study, empirical therapy of pyogenic hepatic abscess always included a drug that is effective against Streptococcus milleri." 11/01/1994 - "Pyogenic liver abscess: studies of therapy and analysis of risk factors." 08/01/1991 - "This study emphasizes the important role of percutaneous drainage as a complementary form of therapy to surgical drainage in the management of pyogenic liver abscesses." 02/21/2023 - "Risk factors indicating the need for surgical therapy in patients with pyogenic liver abscesses." 09/01/2022 - "Therapy of pyogenic liver abscess with a primarily unknown cause."
3.	Critical Care (Surgical Intensive Care) 04/01/2008 - "Four hundred and thirty-six adult patients (> or = 18 yrs) with a diagnosis of pyogenic liver abscess were reviewed, and 72 patients with pyogenic liver abscess who required intensive care were enrolled in the study. " 04/01/2008 - "Clinical outcome and prognostic factors of patients with pyogenic liver abscess requiring intensive care." 04/01/2008 - "In patients with pyogenic liver abscess requiring intensive care, variables including size of liver abscess, pathogens, comorbidity, and most laboratory data were not associated with mortality. " 10/01/2016 - "Among the 1522 adult patients with pyogenic liver abscess, 537 (35.3%) patients had diabetes mellitus, 165 (10.8%) patients had complications, 234 (15.4%) patients received mechanical ventilation, and 361 (23.7%) patients had a stay in intensive care; the mortality rate was 8.2% (125/1522). " 10/01/2011 - "Although Pyogenic Liver Abscess (PLA) has lower mortality rate in recent years due to the broad spectrum antibiotic usage, developed imaging techniques and improved intensive care services, it is still a potentially fatal disease. "
4.	Stents 01/01/2018 - "Pyogenic liver abscess (PLA) of biliary origin in Southeast Asia mainly occurs in patients with intrahepatic bile duct stone (IBDS) and extrahepatic bile duct stone (EBDS), bilioenteric anastomosis, or biliary stent. " 02/01/2002 - "The aims of this study were to compare the effectiveness of percutaneous drainage between pyogenic hepatic abscesses with and those without biliary communication and to evaluate the role of endoscopic biliary stent placement in the treatment of communicating abscesses. " 11/01/2013 - "CT also can be used to evaluate acute biliary diseases such as biliary stone disease, benign and malignant biliary obstruction, acute cholangitis, pyogenic hepatic abscess, hemobilia, and biliary necrosis and iatrogenic complications such as biliary leaks and malfunctioning biliary drains and stents. " 09/01/2019 - "Endoscopic Ultrasound-Guided Hepaticogastrostomy With Lumen-Apposing Metal Stent for Management of Pyogenic Liver Abscess."
5.	Length of Stay 02/11/2021 - "This study aimed to investigate the factors associated with prolonged hospital stay and in-hospital mortality in patients with pyogenic liver abscess. " 08/01/2010 - "Pyogenic liver abscesses are uncommon, and while associated with significant morbidity and prolonged hospital stay, mortality is now rare. " 04/01/1994 - "Our review suggests that pyogenic hepatic abscesses may be treated by several different modalities, the choice of management should be individualized, and the length of stay may be decreased by operative drainage." 07/01/2011 - "Monomicrobial K pneumoniae liver abscesses were associated with significantly shorter duration of antibiotic treatment (P = .018) and hospital stay (P = .005), but there was no significant difference in incidence of septic shock and abscess-related mortality as compared with other pyogenic liver abscesses. "