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Pregnancy-Induced Hypertension (Hypertension, Pregnancy Induced)

A condition in pregnant women with elevated systolic (>140 mm Hg) and diastolic (>90 mm Hg) blood pressure on at least two occasions 6 h apart. HYPERTENSION complicates 8-10% of all pregnancies, generally after 20 weeks of gestation. Gestational hypertension can be divided into several broad categories according to the complexity and associated symptoms, such as EDEMA; PROTEINURIA; SEIZURES; abnormalities in BLOOD COAGULATION and liver functions.
Also Known As:
Hypertension, Pregnancy Induced; Hypertension, Pregnancy-Induced; Gestational Hypertension; Pregnancy Induced Hypertension; Transient Hypertension, Pregnancy; Hypertension, Gestational; Hypertension, Pregnancy Transient; Hypertensions, Pregnancy Induced; Induced Hypertension, Pregnancy; Induced Hypertensions, Pregnancy; Pregnancy Transient Hypertension
Networked: 2892 relevant articles (79 outcomes, 463 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Pre-Eclampsia (Preeclampsia)
2. Hypertension (High Blood Pressure)
3. Fetal Growth Retardation (Intrauterine Growth Retardation)
4. Gestational Weight Gain
5. Gestational Diabetes (Gestational Diabetes Mellitus)

Experts

1. Hromadnikova, Ilona: 13 articles (04/2022 - 01/2013)
2. Kotlabova, Katerina: 13 articles (04/2022 - 01/2013)
3. Krofta, Ladislav: 13 articles (04/2022 - 01/2013)
4. Steegers, Eric A P: 11 articles (01/2021 - 03/2011)
5. von Dadelszen, Peter: 10 articles (01/2022 - 07/2002)
6. Jaddoe, Vincent W V: 10 articles (01/2021 - 03/2011)
7. Nicolaides, Kypros H: 9 articles (12/2022 - 01/2009)
8. Magee, Laura A: 8 articles (01/2022 - 08/2004)
9. Khalil, A: 8 articles (12/2018 - 06/2010)
10. Cavalli, Ricardo C: 8 articles (08/2016 - 07/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pregnancy-Induced Hypertension:
1. CalciumIBA
2. Nifedipine (Adalat)FDA LinkGeneric
3. Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
4. Magnesium Sulfate (Sulfate, Magnesium)FDA LinkGeneric
5. Antihypertensive Agents (Antihypertensives)IBA
6. Dietary CalciumIBA
7. Labetalol (Normodyne)FDA LinkGeneric
8. Pregnancy-Associated Plasma Protein-A (PAPP-A)IBA
9. Proteins (Proteins, Gene)FDA Link
10. MagnesiumIBA

Therapies and Procedures

1. Cesarean Section (Caesarean Section)
2. Therapeutics
3. Induced Labor
4. Bed Rest (Bedrest)
04/04/2005 - "There were no statistically significant differences between the two groups for the primary outcomes birth before 37 weeks (3/3 hospitalisation group versus 4/4 control group; relative risk (RR) not estimable), birth before 34 weeks (3/3 hospitalisation group versus 2/4 control group; RR 2.00 95% Confidence Intervals (CI) 0.75-5.33) and pregnancy induced hypertension (1/3 hospitalisation group versus 1/4 control group; RR 1.33 95%CI 0.13-13.74).When the results of this trial were incorporated into a meta-analysis with the previous randomised controlled trial assessing hospitalisation and bed rest for women with a triplet pregnancy, (total sample size 26 women and 78 infants), there were no statistically significant differences identified between the two groups. "
03/06/2017 - "Women on partial bed rest in hospital were less likely to develop gestational hypertension compared with women without activity restriction at home (RR 0.30, 95% CI 0.16 to 0.59, P = 0.0004, 141 women).Strict or partial bed rest in hospital was found to have no impact on other secondary outcomes. "
09/01/2013 - "This study examined the efficacy of a cardiorespiratory biofeedback intervention compared to bed rest in the treatment of 47 women diagnosed with pregnancy-induced hypertension (PIH). "
04/01/1998 - "MFM directors were significantly more likely to treat pregnancy-induced hypertension (p < 0.01) and placenta previa with hospital bed rest (p < 0.05). "
07/01/2019 - "It is also thought that improved splanchnic perfusion with bedrest may enhance blood supply to the uterus with possible benefit in conditions such as preeclampsia (or gestational hypertension) or fetal growth restriction. "
5. Bariatric Surgery
09/01/2023 - "Bariatric surgeries reduced the rates of GDM, gestational hypertension, PE, and CSs significantly."
03/01/2012 - "The studies show improved fertility and a reduced risk of gestational diabetes, pregnancy-induced hypertension and pre-eclampsia, macrosomia in pregnant women after bariatric surgery. "
11/01/2019 - "Emerging evidence suggests that bariatric surgery improves pregnancy outcomes of women with obesity by reducing the rates of gestational diabetes, pregnancy-induced hypertension, and macrosomia. "
10/19/2023 - "The mainstay treatment for obesity is bariatric surgery, and the following weight reduction results in a decrease in pregnancy adverse effects, including gestational diabetes mellitus, pregnancy-induced hypertension, and macrosomia. "
01/01/2018 - "In our primary analysis, patients who underwent bariatric surgery showed reduced rates of gestational diabetes mellitus (odds ratio, 0.20; 95% confidence interval, 0.11-0.37, number needed to benefit, 5), large-for-gestational-age infants (odds ratio, 0.31; 95% confidence interval, 0.17-0.59; number needed to benefit, 6), gestational hypertension (odds ratio, 0.38; 95% confidence interval, 0.19-0.76; number needed to benefit, 11), all hypertensive disorders (odds ratio, 0.38; 95% confidence interval, 0.27-0.53; number needed to benefit, 8), postpartum hemorrhage (odds ratio, 0.32; 95% confidence interval, 0.08-1.37; number needed to benefit, 21), and caesarean delivery rates (odds ratio, 0.50; 95% confidence interval, 0.38-0.67; number needed to benefit, 9); however, group of patients showed an increase in small-for-gestational-age infants (odds ratio, 2.16; 95% confidence interval, 1.34-3.48; number needed to harm, 21), intrauterine growth restriction (odds ratio, 2.16; 95% confidence interval, 1.34-3.48; number needed to harm, 66), and preterm deliveries (odds ratio, 1.35; 95% confidence interval, 1.02-1.79; number needed to harm, 35) when compared with control subjects who were matched for presurgery body mass index. "