Furin

A proprotein convertase with specificity for the proproteins of PROALBUMIN; COMPLEMENT 3C; and VON WILLEBRAND FACTOR. It has specificity for cleavage near paired ARGININE residues that are separated by two amino acids.

Also Known As:

Networked: 754 relevant articles (23 outcomes, 90 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Seidah, Nabil G: 22 articles (01/2022 - 03/2003)
2.	Khatib, Abdel-Majid: 17 articles (02/2022 - 04/2003)
3.	Day, Robert: 15 articles (03/2021 - 03/2003)
4.	Bassi, Daniel E: 13 articles (04/2019 - 01/2002)
5.	Creemers, John W M: 10 articles (02/2022 - 12/2004)
6.	Desjardins, Roxane: 9 articles (12/2018 - 07/2007)
7.	Lindberg, Iris: 9 articles (01/2017 - 07/2003)
8.	Strongin, Alex Y: 9 articles (06/2010 - 03/2002)
9.	Couture, Frédéric: 8 articles (03/2022 - 11/2012)
10.	Kwiatkowska, Anna: 8 articles (03/2022 - 12/2012)

Related Diseases

1.	Neoplasms (Cancer) 11/22/2016 - "Notably, furin silencing in vivo led to complete remission of established Rh4 tumors and to delayed growth in Rh30 tumors. " 01/01/2021 - "Moreover, survival analysis across cancers revealed that FURIN expression was correlated with overall survival (OS) in four cancers, disease-specific survival (DSS) in five cancers, progression-free interval (PFI) in seven cancers, and disease-free interval (DFI) in two cancers. " 08/19/2009 - "Noninvasive imaging of furin activity will offer a valuable tool to probe furin function over the course of tumor growth and migration in the same animals in real time and directly assess the inhibition efficacy of drugs in vivo. " 01/01/2022 - "In contrast, other studies have revealed that some types of cancer do not benefit from Furin inhibition. " 10/01/2018 - "Overnight fasted plasma furin levels were measured at baseline examination in 4678 individuals from the population-based prospective Malmö Diet and Cancer Study. "
2.	Infections 12/01/2021 - "In addition, phylogenetic analysis using global isolates depicted that the current SARS-CoV-2 isolates possessed a furin cleavage site (NSPRRA) in the RBD, which was absent in the previous isolates that indicated increased efficacy of the present virus for enhanced infection through increased interaction with ACE-2. " 11/15/2007 - "Thus, furin inhibitors are unlikely to be effective in the treatment of filoviral infections." 10/15/2022 - "Recent studies have shown that the furin and TMPRSS2 (furin/TMPRSS2)-dependent pathway plays a minor role in infection of the Omicron variant. " 12/01/2015 - "In this study, we determined FURIN levels in plasma using ELISA from 537 patients that were admitted to emergency room with suspected infection. " 02/01/2013 - "Such effect of furin on chronic HBV infection was investigated in this study. "
3.	Hemophilia A (Haemophilia) 01/01/2017 - "Novel factor VIII variants with a modified furin cleavage site improve the efficacy of gene therapy for hemophilia A." 12/01/2011 - "In addition, our results shown that retaining the 6 N-linked oligosaccharides within a short B-domain spacer associated with 2A and furin cleavage site is expressed more efficiently both in vitro in traditional heterologous expression systems as well as in vivo in a mouse model of hemophilia A." 10/06/2016 - "Circumventing furin enhances factor VIII biological activity and ameliorates bleeding phenotypes in hemophilia models."
4.	COVID-19 01/01/2021 - "In conclusion, the presence of furin cleavage sites might explain the polytropic nature of SARS-CoV-2- and SARS-CoV-2-like CoVs, which would be helpful for ending the COVID-19 pandemic and preventing outbreaks of novel CoVs." 02/16/2022 - "The COVID-19 origin debate has greatly been influenced by genome comparison studies of late, revealing the emergence of the Furin-like cleavage site at the S1/S2 junction of the SARS-CoV-2 Spike (FLCSSpike) containing its 681PRRAR685 motif, absent in other related respiratory viruses. " 01/01/2021 - "Therefore, the present study was designed to investigate the expression of ACE2, furin, TMPRSS2 and ADAM17 in the lung, heart and kidneys of rats with CHF to understand the exaggerated susceptibility of clinical CHF to COVID-19 disease. " 09/01/2023 - "We report the first of its kind of natural furin inhibitor(s) which would disrupt the furin machinery of SARS-CoV-2 and help in controlling the COVID-19 contagion.Communicated" 09/01/2023 - "Natural furin inhibitor(s) as potent therapeutic molecule to mitigate SARS-CoV-2 infection."
5.	Virus Diseases (Viral Diseases) 12/01/2022 - "However, K814A mutation eliminated the enhancing effect of furin on virus infection. " 11/01/2022 - "Bisartans may also act at other targets essential for viral infection and replication (i.e., ACE2, furin cleavage site and 3CLpro), rendering them potential new drugs for additional experimentation and translation to human clinical trials." 01/01/2023 - "Collectively, our data suggest that the T-cell expressed FURIN is important for host responses in viral infections, CTL homeostasis/activation, and memory development." 03/11/2021 - "Furin plays an important role in various pathological states, especially in bacterial and viral infections. " 07/15/2015 - "Thus, compounds 1g and 2f both represent potent furin inhibitors at the cell surface with low intracellular inhibitory action, and these particular compounds might therefore be of preferred therapeutic interest in the treatment of certain bacterial and viral infections. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Proprotein Convertases (Pro-Opiomelanocortin Converting Enzyme)
3.	Peptide Hydrolases (Proteases)
4.	Peptides (Polypeptides)
5.	Antiviral Agents (Antivirals)
6.	Factor VIII (Coagulation Factor VIII)
7.	Messenger RNA (mRNA)
8.	Iron
9.	Hemagglutinins (Hemagglutinin)
10.	Immunotoxins (Immunotoxin)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Radiotherapy
4.	Cell- and Tissue-Based Therapy (Cell Therapy)
5.	Precision Medicine