Furin

A proprotein convertase with specificity for the proproteins of PROALBUMIN; COMPLEMENT 3C; and VON WILLEBRAND FACTOR. It has specificity for cleavage near paired ARGININE residues that are separated by two amino acids.

Also Known As:

Networked: 324 relevant articles (9 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Seidah, Nabil G: 16 articles (01/2015 - 03/2003)
2.	Day, Robert: 11 articles (04/2015 - 03/2003)
3.	Bassi, Daniel E: 9 articles (02/2013 - 06/2002)
4.	Stawowy, Philipp: 9 articles (02/2013 - 03/2003)
5.	Strongin, Alex Y: 9 articles (06/2010 - 03/2002)
6.	Lindberg, Iris: 8 articles (07/2015 - 07/2003)
7.	Khatib, Abdel-Majid: 8 articles (01/2015 - 04/2003)
8.	Fleck, Eckart: 7 articles (02/2013 - 03/2003)
9.	Desjardins, Roxane: 6 articles (01/2014 - 07/2007)
10.	Chrétien, Michel: 6 articles (08/2008 - 03/2003)

Related Diseases

1.	Infection 11/15/2007 - "Thus, furin inhibitors are unlikely to be effective in the treatment of filoviral infections." 12/01/2015 - "In this study, we determined FURIN levels in plasma using ELISA from 537 patients that were admitted to emergency room with suspected infection. " 02/01/2013 - "Such effect of furin on chronic HBV infection was investigated in this study. " 01/01/2012 - "Furthermore, enhancement infection studies with standard (st) DENV preparations opsonized with anti-E mAbs in the presence or absence of furin inhibitor revealed that prM-containing particles present within st virus preparations contribute to antibody-dependent enhancement of infection. " 03/01/2003 - "Studies of unprocessed virus produced in FD11 cells (wt/p62) demonstrated that the p62 protein was efficiently cleaved by purified furin in vitro, without requiring prior exposure to low pH. wt/p62 virus particles were also processed during their endocytic uptake in furin-containing cells, resulting in more efficient virus infection. "
2.	Neoplasms (Cancer) 08/19/2009 - "Noninvasive imaging of furin activity will offer a valuable tool to probe furin function over the course of tumor growth and migration in the same animals in real time and directly assess the inhibition efficacy of drugs in vivo. " 04/01/2015 - "The most advanced application is the use of furin knockdown in the generation of an autologous cancer vaccine, which has initiated clinical trials." 04/01/2012 - "Despite the numerous studies associating furin with tumor development, its effects in preclinical models has not been comprehensively studied. " 08/19/2009 - "Direct imaging of furin activity may facilitate the study of furin function in tumorigenicity and the discovery of new drugs for furin-targeted cancer therapy." 06/16/2015 - "Intracellular Disassembly of Self-Quenched Nanoparticles Turns NIR Fluorescence on for Sensing Furin Activity in Cells and in Tumors."
3.	Influenza in Birds (Avian Flu) 02/01/2014 - "A novel activation mechanism of avian influenza virus H9N2 by furin." 06/01/2010 - "To design potent, safe and selective inhibitors of furin, we evaluated the potency and selectivity of the derivatized peptidic inhibitors modeled from the extended furin cleavage sequence of avian influenza A H5N1. " 07/01/2008 - "Source of high pathogenicity of an avian influenza virus H5N1: why H5 is better cleaved by furin." 07/20/2007 - "Our strategy of basing the peptide sequence on a furin cleavage motif known for an avian flu virus shows the power of starting inhibitor design with a known substrate. " 11/26/1992 - "We have recently found that the enzyme activating the haemagglutinin of fowl plague virus (FPV), an avian influenza virus, is furin. "
4.	Anthrax 06/01/2010 - "These furin inhibitors, however, were highly potent in blocking the furin-dependent cell-surface processing of anthrax protective antigen-83 both in vitro and cell-based assays and in vivo. " 06/01/2010 - "Selective and potent furin inhibitors protect cells from anthrax without significant toxicity." 01/01/2010 - "Our results suggest that there are no physiologically-relevant levels of cell-surface furin and, accordingly, that the mechanisms of anthrax should be re-investigated. " 01/01/2010 - "This observation was in a sharp contrast with the existing concepts about the furin presentation on cell surfaces and anthrax disease mechanism. " 01/01/2010 - "Both because of the sensitivity and selectivity of the anthrax sequence to furin proteolysis and the FRET-based detection, the biosensor recorded the femtomolar levels of furin in the in vitro reactions and cell-based assays. "
5.	Human Influenza (Influenza) 01/01/2015 - "For example, the furin-dependent proteolytic activation of highly pathogenic (HP) influenza A (infA) H5 and H7 haemagglutinin precursor (HA0) subtypes is critical for yielding fusion-competent infectious virions. " 07/15/2009 - "Interestingly, two amino acid substitutions on the prime side of the peptide derived from H5N1 influenza hemagglutinin furin processing site highly improved its hydrolysis. " 07/01/2008 - "The H5N1 influenza variant Fujian-like hemagglutinin selected following vaccination exhibits a compromised furin cleavage : neurological Consequences of highly pathogenic Fujian H5N1 strains." 09/29/1995 - "Also, the envelope proteins of viruses, such as influenza and HIV viruses, need to be processed by furin for infectivity. " 01/09/2014 - "Optimization of furin inhibitors to protect against the activation of influenza hemagglutinin H5 and Shiga toxin."

Related Drugs and Biologics

1.	Proprotein Convertases (Pro-Opiomelanocortin Converting Enzyme)
2.	Hemagglutinins (Hemagglutinin)
3.	Proteins (Proteins, Gene)
4.	Messenger RNA (mRNA)
5.	Iron
6.	Ribavirin (Virazole)
7.	Antiviral Agents (Antivirals)
8.	oseltamivir carboxylate
9.	inter-alpha-inhibitor
10.	Insulin (Novolin)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Therapeutics
3.	Transplants (Transplant)
4.	Blood Component Removal (Apheresis)