DNA Glycosylases (DNA Glycosylase)

A family of DNA repair enzymes that recognize damaged nucleotide bases and remove them by hydrolyzing the N-glycosidic bond that attaches them to the sugar backbone of the DNA molecule. The process called BASE EXCISION REPAIR can be completed by a DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE which excises the remaining RIBOSE sugar from the DNA.

Also Known As:

Networked: 180 relevant articles (3 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bjørås, Magnar: 8 articles (01/2014 - 06/2005)
2.	Nakabeppu, Yusaku: 7 articles (01/2012 - 01/2002)
3.	Bohr, Vilhelm A: 6 articles (01/2015 - 01/2005)
4.	Loft, Steffen: 5 articles (09/2015 - 11/2003)
5.	Møller, Peter: 5 articles (09/2015 - 11/2003)
6.	Luna, Luisa: 5 articles (11/2011 - 06/2005)
7.	Boldogh, Istvan: 4 articles (01/2014 - 09/2007)
8.	Hazra, Tapas K: 4 articles (01/2013 - 02/2003)
9.	Fan, Chun-Yang: 4 articles (06/2008 - 12/2003)
10.	Kang, Lihua: 3 articles (06/2015 - 01/2015)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2004 - "Thus, the depletion of functional DNA glycosylases using covalent trapping may reduce the BER capacity of cancer cells, hence potentiating the efficacy of anticancer drugs or radiation therapy." 02/01/2015 - "The Ser326Cys polymorphism in the human 8-oxogunaine DNA glycosylase (hOGG1) gene had been implicated in cancer susceptibility. " 04/01/2014 - "DNA glycosylases involved in the first steps of the BER pathway may be associated with cancer risk in BRCA1/2 mutation carriers and should be more comprehensively studied." 04/01/2014 - "DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers." 02/01/2014 - "Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: activity, structure, and the effect of editing."
2.	Pneumonia (Pneumonitis) 01/01/2013 - "Down-regulation of 8-oxoguanine DNA glycosylase 1 expression in the airway epithelium ameliorates allergic lung inflammation."
3.	Lung Neoplasms (Lung Cancer) 06/01/2012 - "Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2." 04/01/2012 - "Elevated N3-methylpurine-DNA glycosylase DNA repair activity is associated with lung cancer." 01/01/2010 - "In this study, we tried to assess reported studies of association between polymorphism of human 8-oxoguanine DNA glycosylase 1 (hOGG1) Ser326Cys and lung cancer. " 07/01/2008 - "The potentially functional polymorphism Ser326Cys in the human 8-oxoguanine DNA glycosylase (hOGG1) gene has been implicated in lung cancer risk, but published studies have mixed findings. " 07/01/2006 - "Some studies find positive associations between lung cancer and variations in the human 8-oxoguanine DNA glycosylase (hOGG1) gene that encodes a major DNA glycosylase for oxidized lesions with sluggish kinetics properties. "
4.	Breast Neoplasms (Breast Cancer) 07/01/2010 - "The functional Ser326Cys polymorphism in the human 8-oxogunaine DNA glycosylase (hOGG1) gene has been implicated in breast cancer risk. " 08/01/2001 - "Oxidative DNA damage and 8-hydroxy-2-deoxyguanosine DNA glycosylase/apurinic lyase in human breast cancer." 01/01/2015 - "The purpose of this study was to determine the prognostic role of ten eleven translocation (TET) family proteins and DNA glycosylase (TDG) in patients with early breast cancer (EBC). " 01/01/2014 - "In the current study, we analyzed the possible relation of polymorphisms in BER genes, including 8-oxoguanine DNA glycosylase (OGG1), apurinic/apyrimidinic endonuclease 1 (APE1), and X-ray repair cross-complementing group 1 protein (XRCC1), with breast cancer risk in Chinese Han women. " 01/01/2014 - "In this study, the expression of BER enzymes (redox factor 1/apurinic-apyrimidinic endonuclease 1 (REF1/APEX1), NTH endonuclease III-like 1 (NTHL1), 8-oxoguanine DNA glycosylase (OGG1), PARP1) and of the scaffold protein XRCC1 (X-ray repair complementing defective repair in Chinese hamster cells 1) were investigated in familial (BRCA-related and not) and sporadic breast cancer cases. "
5.	Pancreatic Neoplasms (Pancreatic Cancer) 07/01/2014 - "Previous studies have suggested that the 8-oxoguanine DNA glycosylase gene (OGG1) has potentially influenced the risk of pancreatic cancer. " 01/01/2014 - "This study aimed to evaluate the potential association of single nucleotide polymorphisms of the 8-oxoguanine DNA glycosylase gene (OGG1) with susceptibility to pancreatic cancer (PC). " 01/01/2014 - "The purpose of this study was to test the association between single-nucleotide polymorphisms (SNPs) of 8-oxoguanine DNA glycosylase (OGG1) gene and susceptibility to pancreatic cancer (PC). "

Related Drugs and Biologics

1.	8-hydroxyguanine
2.	DNA-(Apurinic or Apyrimidinic Site) Lyase (AP Endonuclease)
3.	Carotenoids (Carotene)
4.	DNA (Deoxyribonucleic Acid)
5.	Purines
6.	Mitochondrial DNA (mtDNA)
7.	Enzymes
8.	Proteins (Proteins, Gene)
9.	Deoxyribonuclease (Pyrimidine Dimer)
10.	A-Form DNA (A-DNA)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Photochemotherapy (Photodynamic Therapy)
3.	Lenses
4.	Aftercare (After-Treatment)