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Flap Endonucleases

Endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick.
Also Known As:
FEN-1; Fen1 Protein; Flap Endonuclease-1; RAD2 Homolog-1 Nuclease; RTH-1 Nuclease; Endonuclease, Flap; Endonuclease-1, Flap; Endonucleases, Flap; Flap Endonuclease 1; Nuclease, RTH-1; RAD2 Homolog 1 Nuclease; RTH 1 Nuclease; Flap Endonuclease
Networked: 115 relevant articles (1 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Guo, Zhigang: 8 articles (03/2021 - 07/2008)
2. Shen, Binghui: 8 articles (12/2016 - 01/2005)
3. He, Lingfeng: 5 articles (01/2020 - 12/2016)
4. Zheng, Li: 5 articles (02/2015 - 01/2005)
5. Zhang, Jing: 4 articles (04/2022 - 01/2017)
6. Madhusudan, Srinivasan: 4 articles (07/2021 - 06/2013)
7. Hamdan, Samir M: 4 articles (09/2019 - 01/2017)
8. Rashid, Fahad: 4 articles (09/2019 - 01/2017)
9. Finger, L David: 4 articles (12/2018 - 07/2005)
10. Grasby, Jane A: 4 articles (12/2018 - 04/2010)

Related Diseases

1. Genomic Instability
2. Carcinogenesis
3. Neoplasms (Cancer)
4. Breast Neoplasms (Breast Cancer)
5. Stomach Neoplasms (Stomach Cancer)

Related Drugs and Biologics

1. Flap Endonucleases
2. Proteins (Proteins, Gene)
3. Enzymes
4. Exonucleases (3' 5' Exonuclease)
5. Deoxyribonuclease I (Nickase)
6. Uracil-DNA Glycosidase
7. GTP-Binding Proteins (G-Protein)
8. Reactive Oxygen Species (Oxygen Radicals)
9. Arsenic Trioxide (Trisenox)
10. N-(chloroacetyl)glutamate

Related Therapies and Procedures

1. Therapeutics
2. Chinese Traditional Medicine (Traditional Chinese Medicine)
3. Drug Therapy (Chemotherapy)