Tetraoxanes

Compounds with two peroxide groups, that is, two pairs of adjacent OXYGEN atoms. They may have activity against PLASMODIUM similar to the ARTEMISININS.

Also Known As:

1,2,4,5-Tetraoxanes; Tetra-Oxanes; Tetroxanes; Tetra Oxanes

Networked: 8 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
Organic Chemicals: 133
- Free Radicals: 15039
  - Reactive Oxygen Species: 39360
    - Peroxides: 1274
      - Tetraoxanes: 8
        1,10-bis(2-propenyl)-7,8,15,16-tetraoxadispiro(5.2.5.2)-hexadecane
        3,6-dibutanoic-1,2,4,5-tetroxane
        3,6-diphenyl-1,2,4,5-tetroxane
        3-methyl-1,2,4,5-tetroxane
        6-(1,2,6,7-tetraoxaspiro(7.11)nonadec-4-yl)hexan-1-ol
        dispiro-1,2,4,5-tetroxane
        RKA 182

Experts

1.	Cristiano, Maria L S: 3 articles (04/2022 - 09/2012)
2.	Amado, Patrícia S M: 2 articles (04/2022 - 01/2020)
3.	Cabral, Lília I L: 2 articles (04/2022 - 01/2020)
4.	Coghi, Paolo: 2 articles (01/2020 - 01/2018)
5.	Prommana, Parichat: 2 articles (01/2020 - 01/2018)
6.	Radulov, Peter S: 2 articles (01/2020 - 01/2018)
7.	Terent'ev, Alexander O: 2 articles (01/2020 - 01/2018)
8.	Uthaipibull, Chairat: 2 articles (01/2020 - 01/2018)
9.	Wong, Vincent Kam Wai: 2 articles (01/2020 - 01/2018)
10.	Yaremenko, Ivan A: 2 articles (01/2020 - 01/2018)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2009 - "Mixed steroidal tetraoxanes induce apoptotic cell death in tumor cells." 10/18/2007 - "The tetraoxanes presented in this paper are dual inhibitors: besides curing mice in vivo without observed toxic effects, they kill cancer cell lines at very low concentrations. " 01/01/2020 - "Synthetic bridged 1,2,4,5-tetraoxanes and ozonides were effective against HepG2 cancer cells and some ozonides selectively targeted liver cancer cells (the selectivity indexes for compounds 11 b and 12 a are 8 and 5, respectively). " 01/01/2018 - "Twenty six peroxides belonging to bridged 1,2,4,5-tetraoxanes, bridged 1,2,4-trioxolanes (ozonides), and tricyclic monoperoxides were evaluated for their in vitro antimalarial activity against Plasmodium falciparum (3D7) and for their cytotoxic activities against immortalized human normal fibroblast (CCD19Lu), liver (LO2 ), and lung (BEAS-2B) cell lines as well as human liver (HepG2) and lung (A549) cancer-cell lines. "
2.	Malaria 01/01/2009 - "The assay for the in vitro toxicity of water-soluble tetraoxanes 5a-5d to malaria parasites indicate that they were inactive against the Plasmodium falciparum FCR-3 strain." 09/25/2012 - "Although tetraoxanes and trioxolanes have shown promise as next-generation antimalarials, the data described here indicate that adverse effects associated with artemisinins, including embryotoxicity, cannot be ruled out with these novel compounds, and a full understanding of their toxicological actions will be central to the continuing design and development of safe and effective drug candidates which could prove important in the fight against malaria."
3.	Liver Neoplasms (Liver Cancer) 01/01/2020 - "Synthetic bridged 1,2,4,5-tetraoxanes and ozonides were effective against HepG2 cancer cells and some ozonides selectively targeted liver cancer cells (the selectivity indexes for compounds 11 b and 12 a are 8 and 5, respectively). "
4.	Visceral Leishmaniasis (Kala Azar) 04/03/2022 - "This study aimed to evaluate the selectivity of 12 synthetic endoperoxides (1,2,4-trioxolanes; 1,2,4,5-tetraoxanes) and uncover their biochemical effects on Leishmania parasites responsible for visceral leishmaniasis. "
5.	Leishmaniasis 01/22/2020 - "These results provide a relevant basis for the development of further tetraoxanes as effective, safe, and cheap drugs against leishmaniasis."

Related Drugs and Biologics

1.	Antimalarials (Antimalarial Agents)
2.	Artemisinins
3.	Peroxides